Seroepidemiological study of Japanese encephalitis virus in Chiang Mai: Immunity and susceptibility 28 years after introduction of a vaccination programme.
Background Thailand has introduced a nationwide vaccination against Japanese encephalitis virus (JEV) into National Immunization Programme since the 1990's. To improve the understanding of immunity and susceptibility of the population after 28 years of a vaccination programme, we conducted a JE...
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2022
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ftdoajarticles:oai:doaj.org/article:d9d57ca1b0bf4010878379e8ce99c3a3 2023-05-15T15:14:58+02:00 Seroepidemiological study of Japanese encephalitis virus in Chiang Mai: Immunity and susceptibility 28 years after introduction of a vaccination programme. Tavitiya Sudjaritruk Quanhathai Kaewpoowat Chanidapa Prasarakee Saowalak Sarachai Anne-Frieda Taurel Natthanidnan Sricharoen Phatraporn Assawawongprom Jutamad Saheng Rebecca Harris Joshua Nealon Sutee Yoksan 2022-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010674 https://doaj.org/article/d9d57ca1b0bf4010878379e8ce99c3a3 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010674 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010674 https://doaj.org/article/d9d57ca1b0bf4010878379e8ce99c3a3 PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010674 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010674 2022-12-30T23:42:57Z Background Thailand has introduced a nationwide vaccination against Japanese encephalitis virus (JEV) into National Immunization Programme since the 1990's. To improve the understanding of immunity and susceptibility of the population after 28 years of a vaccination programme, we conducted a JEV seroepidemiological study in a JEV-endemic area of Thailand. Methods An age-stratified, population-based, seroepidemiological study was conducted in Chiang Mai, Thailand-a northern Thai province where is an endemic area of Japanese encephalitis. Nine districts were chosen based on administrative definition: rural (n = 3); urban (n = 3); and peri-urban (n = 3). Within each district, eligible participants were randomly selected from 3 age groups: adolescents (10-20 years); adults (21-50 years); and older adults/elderly (≥51 years) by computer randomization. Plaque reduction neutralization tests (PRNT50 and PRNT90) were performed to measure neutralizing antibodies to JEV. To account for the cross-reactivity of JEV and other flaviviruses, JEV seroprotection was defined according to age, previous history of JEV vaccination, and PRNT50/PRNT90 levels of study participants. Results Overall, 279 adolescents, 297 adults, and 297 older adults/elderly were enrolled from nine districts. Age-stratified, protocol-defined, cluster-adjusted JEV seroprotection rates were 61% (95% CI: 48-73%), 43% (95% CI: 31-57%), and 52% (95% CI: 37-67%) for adolescents, adults, and older adults/elderly, respectively. Living in peri-urban districts, having a history of prior dengue virus infection, and previously receiving mouse brain-derived JEV vaccine were significantly associated with seroprotection to JEV in adolescents. Older age and male sex were associated with seroprotection for adults; and only male sex was the associated factor for older adults/elderly (P <0.05). Conclusions Approximately half of population living in a JEV-endemic area demonstrated seroprotection to JEV. Ongoing nationwide surveillance on JEV seropepidemiology is an ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Chiang ENVELOPE(162.650,162.650,-77.967,-77.967) PLOS Neglected Tropical Diseases 16 8 e0010674 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tavitiya Sudjaritruk Quanhathai Kaewpoowat Chanidapa Prasarakee Saowalak Sarachai Anne-Frieda Taurel Natthanidnan Sricharoen Phatraporn Assawawongprom Jutamad Saheng Rebecca Harris Joshua Nealon Sutee Yoksan Seroepidemiological study of Japanese encephalitis virus in Chiang Mai: Immunity and susceptibility 28 years after introduction of a vaccination programme. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Thailand has introduced a nationwide vaccination against Japanese encephalitis virus (JEV) into National Immunization Programme since the 1990's. To improve the understanding of immunity and susceptibility of the population after 28 years of a vaccination programme, we conducted a JEV seroepidemiological study in a JEV-endemic area of Thailand. Methods An age-stratified, population-based, seroepidemiological study was conducted in Chiang Mai, Thailand-a northern Thai province where is an endemic area of Japanese encephalitis. Nine districts were chosen based on administrative definition: rural (n = 3); urban (n = 3); and peri-urban (n = 3). Within each district, eligible participants were randomly selected from 3 age groups: adolescents (10-20 years); adults (21-50 years); and older adults/elderly (≥51 years) by computer randomization. Plaque reduction neutralization tests (PRNT50 and PRNT90) were performed to measure neutralizing antibodies to JEV. To account for the cross-reactivity of JEV and other flaviviruses, JEV seroprotection was defined according to age, previous history of JEV vaccination, and PRNT50/PRNT90 levels of study participants. Results Overall, 279 adolescents, 297 adults, and 297 older adults/elderly were enrolled from nine districts. Age-stratified, protocol-defined, cluster-adjusted JEV seroprotection rates were 61% (95% CI: 48-73%), 43% (95% CI: 31-57%), and 52% (95% CI: 37-67%) for adolescents, adults, and older adults/elderly, respectively. Living in peri-urban districts, having a history of prior dengue virus infection, and previously receiving mouse brain-derived JEV vaccine were significantly associated with seroprotection to JEV in adolescents. Older age and male sex were associated with seroprotection for adults; and only male sex was the associated factor for older adults/elderly (P <0.05). Conclusions Approximately half of population living in a JEV-endemic area demonstrated seroprotection to JEV. Ongoing nationwide surveillance on JEV seropepidemiology is an ... |
format |
Article in Journal/Newspaper |
author |
Tavitiya Sudjaritruk Quanhathai Kaewpoowat Chanidapa Prasarakee Saowalak Sarachai Anne-Frieda Taurel Natthanidnan Sricharoen Phatraporn Assawawongprom Jutamad Saheng Rebecca Harris Joshua Nealon Sutee Yoksan |
author_facet |
Tavitiya Sudjaritruk Quanhathai Kaewpoowat Chanidapa Prasarakee Saowalak Sarachai Anne-Frieda Taurel Natthanidnan Sricharoen Phatraporn Assawawongprom Jutamad Saheng Rebecca Harris Joshua Nealon Sutee Yoksan |
author_sort |
Tavitiya Sudjaritruk |
title |
Seroepidemiological study of Japanese encephalitis virus in Chiang Mai: Immunity and susceptibility 28 years after introduction of a vaccination programme. |
title_short |
Seroepidemiological study of Japanese encephalitis virus in Chiang Mai: Immunity and susceptibility 28 years after introduction of a vaccination programme. |
title_full |
Seroepidemiological study of Japanese encephalitis virus in Chiang Mai: Immunity and susceptibility 28 years after introduction of a vaccination programme. |
title_fullStr |
Seroepidemiological study of Japanese encephalitis virus in Chiang Mai: Immunity and susceptibility 28 years after introduction of a vaccination programme. |
title_full_unstemmed |
Seroepidemiological study of Japanese encephalitis virus in Chiang Mai: Immunity and susceptibility 28 years after introduction of a vaccination programme. |
title_sort |
seroepidemiological study of japanese encephalitis virus in chiang mai: immunity and susceptibility 28 years after introduction of a vaccination programme. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010674 https://doaj.org/article/d9d57ca1b0bf4010878379e8ce99c3a3 |
long_lat |
ENVELOPE(162.650,162.650,-77.967,-77.967) |
geographic |
Arctic Chiang |
geographic_facet |
Arctic Chiang |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010674 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010674 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010674 https://doaj.org/article/d9d57ca1b0bf4010878379e8ce99c3a3 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010674 |
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PLOS Neglected Tropical Diseases |
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