The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria
Parasitic diseases, such as malaria, are an immense burden to many low- and middle-income countries. In 2022, 249 million cases and 608,000 deaths were reported by the World Health Organization for malaria alone. Climate change, conflict, humanitarian crises, resource constraints and diverse biologi...
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Online Access: | https://doi.org/10.3390/idr16040041 https://doaj.org/article/d9b9a8c86a234d86afb50cb3c87a5892 |
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ftdoajarticles:oai:doaj.org/article:d9b9a8c86a234d86afb50cb3c87a5892 2024-09-15T18:26:55+00:00 The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria Alexandra Bourgeois Juliana Aline Souza Lemos Stéphanie Roucheray Audrey Sergerie Dave Richard 2024-06-01T00:00:00Z https://doi.org/10.3390/idr16040041 https://doaj.org/article/d9b9a8c86a234d86afb50cb3c87a5892 EN eng MDPI AG https://www.mdpi.com/2036-7449/16/4/41 https://doaj.org/toc/2036-7449 doi:10.3390/idr16040041 2036-7449 https://doaj.org/article/d9b9a8c86a234d86afb50cb3c87a5892 Infectious Disease Reports, Vol 16, Iss 4, Pp 543-560 (2024) malaria natural compounds northern environments northern molecules Canadian boreal forest metabolites Other systems of medicine RZ201-999 article 2024 ftdoajarticles https://doi.org/10.3390/idr16040041 2024-09-02T15:34:38Z Parasitic diseases, such as malaria, are an immense burden to many low- and middle-income countries. In 2022, 249 million cases and 608,000 deaths were reported by the World Health Organization for malaria alone. Climate change, conflict, humanitarian crises, resource constraints and diverse biological challenges threaten progress in the elimination of malaria. Undeniably, the lack of a commercialized vaccine and the spread of drug-resistant parasites beg the need for novel approaches to treat this infectious disease. Most approaches for the development of antimalarials to date take inspiration from tropical or sub-tropical environments; however, it is necessary to expand our search. In this review, we highlight the origin of antimalarial treatments and propose new insights in the search for developing novel antiparasitic treatments. Plants and microorganisms living in harsh and cold environments, such as those found in the largely unexploited Northern Canadian boreal forest, often demonstrate interesting properties that are not found in other environments. Most prominently, the essential oil of Rhododendron tomentosum spp. Subarcticum from Nunavik and mortiamides isolated from Mortierella species found in Nunavut have shown promising activity against Plasmodium falciparum . Article in Journal/Newspaper Nunavut Nunavik Directory of Open Access Journals: DOAJ Articles Infectious Disease Reports 16 4 543 560 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
malaria natural compounds northern environments northern molecules Canadian boreal forest metabolites Other systems of medicine RZ201-999 |
spellingShingle |
malaria natural compounds northern environments northern molecules Canadian boreal forest metabolites Other systems of medicine RZ201-999 Alexandra Bourgeois Juliana Aline Souza Lemos Stéphanie Roucheray Audrey Sergerie Dave Richard The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria |
topic_facet |
malaria natural compounds northern environments northern molecules Canadian boreal forest metabolites Other systems of medicine RZ201-999 |
description |
Parasitic diseases, such as malaria, are an immense burden to many low- and middle-income countries. In 2022, 249 million cases and 608,000 deaths were reported by the World Health Organization for malaria alone. Climate change, conflict, humanitarian crises, resource constraints and diverse biological challenges threaten progress in the elimination of malaria. Undeniably, the lack of a commercialized vaccine and the spread of drug-resistant parasites beg the need for novel approaches to treat this infectious disease. Most approaches for the development of antimalarials to date take inspiration from tropical or sub-tropical environments; however, it is necessary to expand our search. In this review, we highlight the origin of antimalarial treatments and propose new insights in the search for developing novel antiparasitic treatments. Plants and microorganisms living in harsh and cold environments, such as those found in the largely unexploited Northern Canadian boreal forest, often demonstrate interesting properties that are not found in other environments. Most prominently, the essential oil of Rhododendron tomentosum spp. Subarcticum from Nunavik and mortiamides isolated from Mortierella species found in Nunavut have shown promising activity against Plasmodium falciparum . |
format |
Article in Journal/Newspaper |
author |
Alexandra Bourgeois Juliana Aline Souza Lemos Stéphanie Roucheray Audrey Sergerie Dave Richard |
author_facet |
Alexandra Bourgeois Juliana Aline Souza Lemos Stéphanie Roucheray Audrey Sergerie Dave Richard |
author_sort |
Alexandra Bourgeois |
title |
The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria |
title_short |
The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria |
title_full |
The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria |
title_fullStr |
The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria |
title_full_unstemmed |
The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria |
title_sort |
paradigm shift of using natural molecules extracted from northern canada to combat malaria |
publisher |
MDPI AG |
publishDate |
2024 |
url |
https://doi.org/10.3390/idr16040041 https://doaj.org/article/d9b9a8c86a234d86afb50cb3c87a5892 |
genre |
Nunavut Nunavik |
genre_facet |
Nunavut Nunavik |
op_source |
Infectious Disease Reports, Vol 16, Iss 4, Pp 543-560 (2024) |
op_relation |
https://www.mdpi.com/2036-7449/16/4/41 https://doaj.org/toc/2036-7449 doi:10.3390/idr16040041 2036-7449 https://doaj.org/article/d9b9a8c86a234d86afb50cb3c87a5892 |
op_doi |
https://doi.org/10.3390/idr16040041 |
container_title |
Infectious Disease Reports |
container_volume |
16 |
container_issue |
4 |
container_start_page |
543 |
op_container_end_page |
560 |
_version_ |
1810467564449431552 |