Familial Aggregation and Heritability of Myopia: A Local Population Survey in Shanxi, China
Purpose. To further determine the roles of environmental and genetic factors in the development of myopia, a comprehensive survey was performed. The guidance for myopia-susceptible people is established which might help prevent or delay the onset and development of myopia. Methods. 1,852 students we...
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ftdoajarticles:oai:doaj.org/article:d9aac2df71974652b513be64f0b7e0d0 2024-10-20T14:07:25+00:00 Familial Aggregation and Heritability of Myopia: A Local Population Survey in Shanxi, China Qin Wang Hao-Yu Bi Chun-Fang Wang 2021-01-01T00:00:00Z https://doi.org/10.1155/2021/4847112 https://doaj.org/article/d9aac2df71974652b513be64f0b7e0d0 EN eng Hindawi Limited http://dx.doi.org/10.1155/2021/4847112 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 doi:10.1155/2021/4847112 https://doaj.org/article/d9aac2df71974652b513be64f0b7e0d0 Journal of Tropical Medicine, Vol 2021 (2021) Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.1155/2021/4847112 2024-10-09T17:27:37Z Purpose. To further determine the roles of environmental and genetic factors in the development of myopia, a comprehensive survey was performed. The guidance for myopia-susceptible people is established which might help prevent or delay the onset and development of myopia. Methods. 1,852 students were recruited using the multistage sampling approach from the Gaoping county in Shanxi. The refractive status of students was examined using an autorefractometer, and the refractive status of students’ first-degree relatives was collected using a well-designed questionnaire. Family aggregation of myopia was analyzed according to the myopic status of the students (nonmyopic or myopic group). The prevalence and heritability of myopia in students and their first-degree relatives were further explored by subdividing into mild, moderate, and high myopia groups. Significance analysis among each group was performed by the χ2 test using SPSS 25.0 software. Falconer’s method was used to calculate the inheritability of myopia. Results. A total of 1,852 subjects were recruited in this study, and 1,813 subjects were finally included. The family aggregation of myopia in the myopic student group (34.7%) was significantly higher than that in the nonmyopic group (8.5%). The prevalence of mild, moderate, and high myopia in children (students and siblings) was higher than that in their parents. The rate of high myopia (6.33%) was significantly higher among students with one or both myopic parents than those without myopic parents (3.85%). The heritability of mild, moderate, and high myopia among parents-offspring was 3.72%, 20.47%, and 48.00%, respectively. The heritability of mild, moderate, and high myopia among siblings was 17.50%, 86.09%, and 78.75%, which is significantly higher than that among parents-offspring. In addition to genetic factors, extensive near-work time, higher education pressure, and minimal outdoor activities contribute significantly to mild and moderate myopia. Conclusions. Myopia is of high risk due to familial ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2021 1 7 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 Qin Wang Hao-Yu Bi Chun-Fang Wang Familial Aggregation and Heritability of Myopia: A Local Population Survey in Shanxi, China |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Purpose. To further determine the roles of environmental and genetic factors in the development of myopia, a comprehensive survey was performed. The guidance for myopia-susceptible people is established which might help prevent or delay the onset and development of myopia. Methods. 1,852 students were recruited using the multistage sampling approach from the Gaoping county in Shanxi. The refractive status of students was examined using an autorefractometer, and the refractive status of students’ first-degree relatives was collected using a well-designed questionnaire. Family aggregation of myopia was analyzed according to the myopic status of the students (nonmyopic or myopic group). The prevalence and heritability of myopia in students and their first-degree relatives were further explored by subdividing into mild, moderate, and high myopia groups. Significance analysis among each group was performed by the χ2 test using SPSS 25.0 software. Falconer’s method was used to calculate the inheritability of myopia. Results. A total of 1,852 subjects were recruited in this study, and 1,813 subjects were finally included. The family aggregation of myopia in the myopic student group (34.7%) was significantly higher than that in the nonmyopic group (8.5%). The prevalence of mild, moderate, and high myopia in children (students and siblings) was higher than that in their parents. The rate of high myopia (6.33%) was significantly higher among students with one or both myopic parents than those without myopic parents (3.85%). The heritability of mild, moderate, and high myopia among parents-offspring was 3.72%, 20.47%, and 48.00%, respectively. The heritability of mild, moderate, and high myopia among siblings was 17.50%, 86.09%, and 78.75%, which is significantly higher than that among parents-offspring. In addition to genetic factors, extensive near-work time, higher education pressure, and minimal outdoor activities contribute significantly to mild and moderate myopia. Conclusions. Myopia is of high risk due to familial ... |
format |
Article in Journal/Newspaper |
author |
Qin Wang Hao-Yu Bi Chun-Fang Wang |
author_facet |
Qin Wang Hao-Yu Bi Chun-Fang Wang |
author_sort |
Qin Wang |
title |
Familial Aggregation and Heritability of Myopia: A Local Population Survey in Shanxi, China |
title_short |
Familial Aggregation and Heritability of Myopia: A Local Population Survey in Shanxi, China |
title_full |
Familial Aggregation and Heritability of Myopia: A Local Population Survey in Shanxi, China |
title_fullStr |
Familial Aggregation and Heritability of Myopia: A Local Population Survey in Shanxi, China |
title_full_unstemmed |
Familial Aggregation and Heritability of Myopia: A Local Population Survey in Shanxi, China |
title_sort |
familial aggregation and heritability of myopia: a local population survey in shanxi, china |
publisher |
Hindawi Limited |
publishDate |
2021 |
url |
https://doi.org/10.1155/2021/4847112 https://doaj.org/article/d9aac2df71974652b513be64f0b7e0d0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2021 (2021) |
op_relation |
http://dx.doi.org/10.1155/2021/4847112 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 doi:10.1155/2021/4847112 https://doaj.org/article/d9aac2df71974652b513be64f0b7e0d0 |
op_doi |
https://doi.org/10.1155/2021/4847112 |
container_title |
Journal of Tropical Medicine |
container_volume |
2021 |
container_start_page |
1 |
op_container_end_page |
7 |
_version_ |
1813446332906471424 |