Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights
Mohamed A Abdelgawad,1 Arafa Musa,2 Atiah H Almalki,3,4 Sami I Alzarea,5 Ehab M Mostafa,2 Mostafa M Hegazy,6 Gomaa Mostafa-Hedeab,7 Mohammed M Ghoneim,6,8 Della GT Parambi,1 Rania B Bakr,1 Nayef S Al-Muaikel,9 Abdullah S Alanazi,10,11 Metab Alharbi,12 Waqas Ahmad,13 Syed NA Bukhari,1 Mohammad M Al-S...
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Dove Medical Press
2021
|
Subjects: | |
Online Access: | https://doaj.org/article/d978c634b0c9407aaf2765ca66f411ac |
id |
ftdoajarticles:oai:doaj.org/article:d978c634b0c9407aaf2765ca66f411ac |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:d978c634b0c9407aaf2765ca66f411ac 2023-05-15T18:13:04+02:00 Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights Abdelgawad MA Musa A Almalki AH Alzarea SI Mostafa EM Hegazy MM Mostafa-Hedeab G Ghoneim MM Parambi DGT Bakr RB Al-Muaikel NS Alanazi AS Alharbi M Ahmad W Bukhari SNA Al-Sanea MM 2021-05-01T00:00:00Z https://doaj.org/article/d978c634b0c9407aaf2765ca66f411ac EN eng Dove Medical Press https://www.dovepress.com/novel-phenolic-compounds-as-potential-dual-egfr-and-cox-2-inhibitors-d-peer-reviewed-fulltext-article-DDDT https://doaj.org/toc/1177-8881 1177-8881 https://doaj.org/article/d978c634b0c9407aaf2765ca66f411ac Drug Design, Development and Therapy, Vol Volume 15, Pp 2325-2337 (2021) kinase inhibitors anti-inflammatory multitarget agents braf anticancer Therapeutics. Pharmacology RM1-950 article 2021 ftdoajarticles 2022-12-31T06:14:41Z Mohamed A Abdelgawad,1 Arafa Musa,2 Atiah H Almalki,3,4 Sami I Alzarea,5 Ehab M Mostafa,2 Mostafa M Hegazy,6 Gomaa Mostafa-Hedeab,7 Mohammed M Ghoneim,6,8 Della GT Parambi,1 Rania B Bakr,1 Nayef S Al-Muaikel,9 Abdullah S Alanazi,10,11 Metab Alharbi,12 Waqas Ahmad,13 Syed NA Bukhari,1 Mohammad M Al-Sanea1 1Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia; 2Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, 72341, Saudi Arabia; 3Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, 21944, Saudi Arabia; 4Addiction and Neuroscience Research Unit, Taif University, Taif, 21944, Saudi Arabia; 5Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia; 6Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, 11371, Egypt; 7Department of Pharmacology, Medical College, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia; 8Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, 13713, Saudi Arabia; 9Department of Chemistry, College of Science, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia; 10Department of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia; 11Health Sciences Research Unit, Jouf University, Sakaka, Aljouf, Saudi Arabia; 12Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia; 13Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaCorrespondence: Mohamed A AbdelgawadDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Kingdom of Saudi ArabiaTel +966 595435214Email mohamedabdelwahab976@yahoo.comArafa MusaDepartment of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Kingdom of Saudi ArabiaTel +966 558775403Email akmusa@ju.edu.saIntroduction: Epidermal growth factor ... Article in Journal/Newspaper sami Directory of Open Access Journals: DOAJ Articles Musa ENVELOPE(9.617,9.617,63.587,63.587) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
kinase inhibitors anti-inflammatory multitarget agents braf anticancer Therapeutics. Pharmacology RM1-950 |
spellingShingle |
kinase inhibitors anti-inflammatory multitarget agents braf anticancer Therapeutics. Pharmacology RM1-950 Abdelgawad MA Musa A Almalki AH Alzarea SI Mostafa EM Hegazy MM Mostafa-Hedeab G Ghoneim MM Parambi DGT Bakr RB Al-Muaikel NS Alanazi AS Alharbi M Ahmad W Bukhari SNA Al-Sanea MM Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights |
topic_facet |
kinase inhibitors anti-inflammatory multitarget agents braf anticancer Therapeutics. Pharmacology RM1-950 |
description |
Mohamed A Abdelgawad,1 Arafa Musa,2 Atiah H Almalki,3,4 Sami I Alzarea,5 Ehab M Mostafa,2 Mostafa M Hegazy,6 Gomaa Mostafa-Hedeab,7 Mohammed M Ghoneim,6,8 Della GT Parambi,1 Rania B Bakr,1 Nayef S Al-Muaikel,9 Abdullah S Alanazi,10,11 Metab Alharbi,12 Waqas Ahmad,13 Syed NA Bukhari,1 Mohammad M Al-Sanea1 1Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia; 2Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, 72341, Saudi Arabia; 3Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, 21944, Saudi Arabia; 4Addiction and Neuroscience Research Unit, Taif University, Taif, 21944, Saudi Arabia; 5Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia; 6Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, 11371, Egypt; 7Department of Pharmacology, Medical College, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia; 8Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, 13713, Saudi Arabia; 9Department of Chemistry, College of Science, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia; 10Department of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia; 11Health Sciences Research Unit, Jouf University, Sakaka, Aljouf, Saudi Arabia; 12Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia; 13Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaCorrespondence: Mohamed A AbdelgawadDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Kingdom of Saudi ArabiaTel +966 595435214Email mohamedabdelwahab976@yahoo.comArafa MusaDepartment of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Kingdom of Saudi ArabiaTel +966 558775403Email akmusa@ju.edu.saIntroduction: Epidermal growth factor ... |
format |
Article in Journal/Newspaper |
author |
Abdelgawad MA Musa A Almalki AH Alzarea SI Mostafa EM Hegazy MM Mostafa-Hedeab G Ghoneim MM Parambi DGT Bakr RB Al-Muaikel NS Alanazi AS Alharbi M Ahmad W Bukhari SNA Al-Sanea MM |
author_facet |
Abdelgawad MA Musa A Almalki AH Alzarea SI Mostafa EM Hegazy MM Mostafa-Hedeab G Ghoneim MM Parambi DGT Bakr RB Al-Muaikel NS Alanazi AS Alharbi M Ahmad W Bukhari SNA Al-Sanea MM |
author_sort |
Abdelgawad MA |
title |
Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights |
title_short |
Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights |
title_full |
Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights |
title_fullStr |
Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights |
title_full_unstemmed |
Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights |
title_sort |
novel phenolic compounds as potential dual egfr and cox-2 inhibitors: design, semisynthesis, in vitro biological evaluation and in silico insights |
publisher |
Dove Medical Press |
publishDate |
2021 |
url |
https://doaj.org/article/d978c634b0c9407aaf2765ca66f411ac |
long_lat |
ENVELOPE(9.617,9.617,63.587,63.587) |
geographic |
Musa |
geographic_facet |
Musa |
genre |
sami |
genre_facet |
sami |
op_source |
Drug Design, Development and Therapy, Vol Volume 15, Pp 2325-2337 (2021) |
op_relation |
https://www.dovepress.com/novel-phenolic-compounds-as-potential-dual-egfr-and-cox-2-inhibitors-d-peer-reviewed-fulltext-article-DDDT https://doaj.org/toc/1177-8881 1177-8881 https://doaj.org/article/d978c634b0c9407aaf2765ca66f411ac |
_version_ |
1766185550863138816 |