Estudos sôbre a excitação química da córtex cerebral (Ação da acetilcolina)
The author has studied the influence of acetylcholine solutions directly applied on the motor cortex of dogs, cats monkeys and rabbits. For this purpose small squares of filter paper were soaked in the acetylcholine solution and soon afterwards laid on the motor cortex. Solutions varying from 0,2 to...
Published in: | Memórias do Instituto Oswaldo Cruz |
---|---|
Main Author: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
1945
|
Subjects: | |
Online Access: | https://doi.org/10.1590/S0074-02761945000200008 https://doaj.org/article/d905df35ccd549f5a22e893603b7506c |
id |
ftdoajarticles:oai:doaj.org/article:d905df35ccd549f5a22e893603b7506c |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:d905df35ccd549f5a22e893603b7506c 2023-05-15T15:14:52+02:00 Estudos sôbre a excitação química da córtex cerebral (Ação da acetilcolina) H. Mcussatché 1945-04-01T00:00:00Z https://doi.org/10.1590/S0074-02761945000200008 https://doaj.org/article/d905df35ccd549f5a22e893603b7506c EN eng Instituto Oswaldo Cruz, Ministério da Saúde http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761945000200008 https://doaj.org/toc/0074-0276 https://doaj.org/toc/1678-8060 doi:10.1590/S0074-02761945000200008 0074-0276 1678-8060 https://doaj.org/article/d905df35ccd549f5a22e893603b7506c Memórias do Instituto Oswaldo Cruz., Vol 42, Iss 2, Pp 365-400 (1945) Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 article 1945 ftdoajarticles https://doi.org/10.1590/S0074-02761945000200008 2023-01-08T01:33:51Z The author has studied the influence of acetylcholine solutions directly applied on the motor cortex of dogs, cats monkeys and rabbits. For this purpose small squares of filter paper were soaked in the acetylcholine solution and soon afterwards laid on the motor cortex. Solutions varying from 0,2 to 10 per cent have been experimented. It has been shown that local application of the solutions on the motor points, previously localized by induction coil, produced motor reactions. It has been found, in the dogs that 10 per cent acetylcholine solutions cause localized muscular twitchings (clonus) in almost all the animals experimented. Generalised epileptiform convulsions were obtained in44,4% of the dogs. Convulsions were also obtained by employing 1 per cent solution of acetylcholine. Definite response has been obtained with 0,2 per cent solution. Failure of motor action, pointed out by other authors, has been related to the use of anesthetics. Convulsions were easily produced by rapid light mechanical stimulations of the skin covering the muscles in conection with the excited motor point, and the application on the motor point of acetylcholine. The results on monkeys can be summarized as follows. Two species of monkeys were experimented: Cebus capucinus and Macaca mulata. In the monkeys C. capucinus generalised convulsive reactions were induced with actylcholine solutions in a concentration as low as 0,5 per cent. Motor reaction or convulsive seizeres were obtained in seven of the eight monkeys used. Three monkeys M. mulata were stimulated with 10 per cent acetylcholine solution but only localized muscular contraction hae been observed. Similar results has been obtained on the motor cortex of cats and rabbits. One of the three cats employed has shown epileptiform convulsions and the remaining only localized muscular contractions. In the rabbits muscular twitchings have been also induced. The sensitizing power of eserine on the action of acetylcholine has been also searched. The results indicate that a previous ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Memórias do Instituto Oswaldo Cruz 42 2 365 400 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 H. Mcussatché Estudos sôbre a excitação química da córtex cerebral (Ação da acetilcolina) |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Microbiology QR1-502 |
description |
The author has studied the influence of acetylcholine solutions directly applied on the motor cortex of dogs, cats monkeys and rabbits. For this purpose small squares of filter paper were soaked in the acetylcholine solution and soon afterwards laid on the motor cortex. Solutions varying from 0,2 to 10 per cent have been experimented. It has been shown that local application of the solutions on the motor points, previously localized by induction coil, produced motor reactions. It has been found, in the dogs that 10 per cent acetylcholine solutions cause localized muscular twitchings (clonus) in almost all the animals experimented. Generalised epileptiform convulsions were obtained in44,4% of the dogs. Convulsions were also obtained by employing 1 per cent solution of acetylcholine. Definite response has been obtained with 0,2 per cent solution. Failure of motor action, pointed out by other authors, has been related to the use of anesthetics. Convulsions were easily produced by rapid light mechanical stimulations of the skin covering the muscles in conection with the excited motor point, and the application on the motor point of acetylcholine. The results on monkeys can be summarized as follows. Two species of monkeys were experimented: Cebus capucinus and Macaca mulata. In the monkeys C. capucinus generalised convulsive reactions were induced with actylcholine solutions in a concentration as low as 0,5 per cent. Motor reaction or convulsive seizeres were obtained in seven of the eight monkeys used. Three monkeys M. mulata were stimulated with 10 per cent acetylcholine solution but only localized muscular contraction hae been observed. Similar results has been obtained on the motor cortex of cats and rabbits. One of the three cats employed has shown epileptiform convulsions and the remaining only localized muscular contractions. In the rabbits muscular twitchings have been also induced. The sensitizing power of eserine on the action of acetylcholine has been also searched. The results indicate that a previous ... |
format |
Article in Journal/Newspaper |
author |
H. Mcussatché |
author_facet |
H. Mcussatché |
author_sort |
H. Mcussatché |
title |
Estudos sôbre a excitação química da córtex cerebral (Ação da acetilcolina) |
title_short |
Estudos sôbre a excitação química da córtex cerebral (Ação da acetilcolina) |
title_full |
Estudos sôbre a excitação química da córtex cerebral (Ação da acetilcolina) |
title_fullStr |
Estudos sôbre a excitação química da córtex cerebral (Ação da acetilcolina) |
title_full_unstemmed |
Estudos sôbre a excitação química da córtex cerebral (Ação da acetilcolina) |
title_sort |
estudos sôbre a excitação química da córtex cerebral (ação da acetilcolina) |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
publishDate |
1945 |
url |
https://doi.org/10.1590/S0074-02761945000200008 https://doaj.org/article/d905df35ccd549f5a22e893603b7506c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Memórias do Instituto Oswaldo Cruz., Vol 42, Iss 2, Pp 365-400 (1945) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761945000200008 https://doaj.org/toc/0074-0276 https://doaj.org/toc/1678-8060 doi:10.1590/S0074-02761945000200008 0074-0276 1678-8060 https://doaj.org/article/d905df35ccd549f5a22e893603b7506c |
op_doi |
https://doi.org/10.1590/S0074-02761945000200008 |
container_title |
Memórias do Instituto Oswaldo Cruz |
container_volume |
42 |
container_issue |
2 |
container_start_page |
365 |
op_container_end_page |
400 |
_version_ |
1766345264657858560 |