Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi
A competitive antibody enzyme immunoassay, using a monoclonal antibody against the species-specific Trypanosoma crnzi antigen 5, was used to investigate the presence of anti-component 5 antibodies in sera of opossums, dogs, rabbits and rats infected with this parasite. The sera from 51 Venezuelan pa...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
1987
|
Subjects: | |
Online Access: | https://doi.org/10.1590/S0037-86821987000200005 https://doaj.org/article/d8adb8b4fa824fc78a0e60fd86c4cce1 |
id |
ftdoajarticles:oai:doaj.org/article:d8adb8b4fa824fc78a0e60fd86c4cce1 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:d8adb8b4fa824fc78a0e60fd86c4cce1 2023-05-15T15:02:39+02:00 Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi F. Santoro M. Sadigursky I. Sherlock D. Afchain A. Capron 1987-06-01T00:00:00Z https://doi.org/10.1590/S0037-86821987000200005 https://doaj.org/article/d8adb8b4fa824fc78a0e60fd86c4cce1 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821987000200005&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821987000200005 https://doaj.org/article/d8adb8b4fa824fc78a0e60fd86c4cce1 Revista da Sociedade Brasileira de Medicina Tropical, Vol 20, Iss 2, Pp 91-94 (1987) Trypanosoma cruzi Anticorpos Imuno-ensaio Arctic medicine. Tropical medicine RC955-962 article 1987 ftdoajarticles https://doi.org/10.1590/S0037-86821987000200005 2022-12-30T23:21:44Z A competitive antibody enzyme immunoassay, using a monoclonal antibody against the species-specific Trypanosoma crnzi antigen 5, was used to investigate the presence of anti-component 5 antibodies in sera of opossums, dogs, rabbits and rats infected with this parasite. The sera from 51 Venezuelan patients with Chagas’disease were also tested. About 90% of the infected subjects showed significant levels of anti-component 5 antibodies. Nevertheless, these antibodies were not detected in the sera of dogs, rats and opossums infected with T. cruzl Some sera from infected rabbits presented significant results but close to the limit ofpositivity ofthe test. These findings suggest that the immune response in animals naturally or experimentally infected with T. cruzi is different from that observed in human Chagas’disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 20 2 91 94 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Trypanosoma cruzi Anticorpos Imuno-ensaio Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Trypanosoma cruzi Anticorpos Imuno-ensaio Arctic medicine. Tropical medicine RC955-962 F. Santoro M. Sadigursky I. Sherlock D. Afchain A. Capron Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi |
topic_facet |
Trypanosoma cruzi Anticorpos Imuno-ensaio Arctic medicine. Tropical medicine RC955-962 |
description |
A competitive antibody enzyme immunoassay, using a monoclonal antibody against the species-specific Trypanosoma crnzi antigen 5, was used to investigate the presence of anti-component 5 antibodies in sera of opossums, dogs, rabbits and rats infected with this parasite. The sera from 51 Venezuelan patients with Chagas’disease were also tested. About 90% of the infected subjects showed significant levels of anti-component 5 antibodies. Nevertheless, these antibodies were not detected in the sera of dogs, rats and opossums infected with T. cruzl Some sera from infected rabbits presented significant results but close to the limit ofpositivity ofthe test. These findings suggest that the immune response in animals naturally or experimentally infected with T. cruzi is different from that observed in human Chagas’disease. |
format |
Article in Journal/Newspaper |
author |
F. Santoro M. Sadigursky I. Sherlock D. Afchain A. Capron |
author_facet |
F. Santoro M. Sadigursky I. Sherlock D. Afchain A. Capron |
author_sort |
F. Santoro |
title |
Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi |
title_short |
Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi |
title_full |
Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi |
title_fullStr |
Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi |
title_full_unstemmed |
Studies on anti-component 5 antibodies in animals infected with Trypanosoma cruzi |
title_sort |
studies on anti-component 5 antibodies in animals infected with trypanosoma cruzi |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1987 |
url |
https://doi.org/10.1590/S0037-86821987000200005 https://doaj.org/article/d8adb8b4fa824fc78a0e60fd86c4cce1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 20, Iss 2, Pp 91-94 (1987) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821987000200005&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821987000200005 https://doaj.org/article/d8adb8b4fa824fc78a0e60fd86c4cce1 |
op_doi |
https://doi.org/10.1590/S0037-86821987000200005 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
20 |
container_issue |
2 |
container_start_page |
91 |
op_container_end_page |
94 |
_version_ |
1766334582734454784 |