Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages.
Based on spatiotemporal clustering of human dengue virus (DENV) infections, transmission is thought to occur at fine spatiotemporal scales by horizontal transfer of virus between humans and mosquito vectors. To define the dimensions of local transmission and quantify the factors that support it, we...
Published in: | PLoS Neglected Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:d8542e1605974b54bef2e0a984e53f97 2023-05-15T15:14:22+02:00 Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages. In-Kyu Yoon Arthur Getis Jared Aldstadt Alan L Rothman Darunee Tannitisupawong Constantianus J M Koenraadt Thanyalak Fansiri James W Jones Amy C Morrison Richard G Jarman Ananda Nisalak Mammen P Mammen Suwich Thammapalo Anon Srikiatkhachorn Sharone Green Daniel H Libraty Robert V Gibbons Timothy Endy Chusak Pimgate Thomas W Scott 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001730 https://doaj.org/article/d8542e1605974b54bef2e0a984e53f97 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3398976?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001730 https://doaj.org/article/d8542e1605974b54bef2e0a984e53f97 PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1730 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001730 2022-12-31T12:01:59Z Based on spatiotemporal clustering of human dengue virus (DENV) infections, transmission is thought to occur at fine spatiotemporal scales by horizontal transfer of virus between humans and mosquito vectors. To define the dimensions of local transmission and quantify the factors that support it, we examined relationships between infected humans and Aedes aegypti in Thai villages.Geographic cluster investigations of 100-meter radius were conducted around DENV-positive and DENV-negative febrile "index" cases (positive and negative clusters, respectively) from a longitudinal cohort study in rural Thailand. Child contacts and Ae. aegypti from cluster houses were assessed for DENV infection. Spatiotemporal, demographic, and entomological parameters were evaluated. In positive clusters, the DENV infection rate among child contacts was 35.3% in index houses, 29.9% in houses within 20 meters, and decreased with distance from the index house to 6.2% in houses 80-100 meters away (p<0.001). Significantly more Ae. aegypti were DENV-infectious (i.e., DENV-positive in head/thorax) in positive clusters (23/1755; 1.3%) than negative clusters (1/1548; 0.1%). In positive clusters, 8.2% of mosquitoes were DENV-infectious in index houses, 4.2% in other houses with DENV-infected children, and 0.4% in houses without infected children (p<0.001). The DENV infection rate in contacts was 47.4% in houses with infectious mosquitoes, 28.7% in other houses in the same cluster, and 10.8% in positive clusters without infectious mosquitoes (p<0.001). Ae. aegypti pupae and adult females were more numerous only in houses containing infectious mosquitoes.Human and mosquito infections are positively associated at the level of individual houses and neighboring residences. Certain houses with high transmission risk contribute disproportionately to DENV spread to neighboring houses. Small groups of houses with elevated transmission risk are consistent with over-dispersion of transmission (i.e., at a given point in time, people/mosquitoes from ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 7 e1730 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 In-Kyu Yoon Arthur Getis Jared Aldstadt Alan L Rothman Darunee Tannitisupawong Constantianus J M Koenraadt Thanyalak Fansiri James W Jones Amy C Morrison Richard G Jarman Ananda Nisalak Mammen P Mammen Suwich Thammapalo Anon Srikiatkhachorn Sharone Green Daniel H Libraty Robert V Gibbons Timothy Endy Chusak Pimgate Thomas W Scott Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Based on spatiotemporal clustering of human dengue virus (DENV) infections, transmission is thought to occur at fine spatiotemporal scales by horizontal transfer of virus between humans and mosquito vectors. To define the dimensions of local transmission and quantify the factors that support it, we examined relationships between infected humans and Aedes aegypti in Thai villages.Geographic cluster investigations of 100-meter radius were conducted around DENV-positive and DENV-negative febrile "index" cases (positive and negative clusters, respectively) from a longitudinal cohort study in rural Thailand. Child contacts and Ae. aegypti from cluster houses were assessed for DENV infection. Spatiotemporal, demographic, and entomological parameters were evaluated. In positive clusters, the DENV infection rate among child contacts was 35.3% in index houses, 29.9% in houses within 20 meters, and decreased with distance from the index house to 6.2% in houses 80-100 meters away (p<0.001). Significantly more Ae. aegypti were DENV-infectious (i.e., DENV-positive in head/thorax) in positive clusters (23/1755; 1.3%) than negative clusters (1/1548; 0.1%). In positive clusters, 8.2% of mosquitoes were DENV-infectious in index houses, 4.2% in other houses with DENV-infected children, and 0.4% in houses without infected children (p<0.001). The DENV infection rate in contacts was 47.4% in houses with infectious mosquitoes, 28.7% in other houses in the same cluster, and 10.8% in positive clusters without infectious mosquitoes (p<0.001). Ae. aegypti pupae and adult females were more numerous only in houses containing infectious mosquitoes.Human and mosquito infections are positively associated at the level of individual houses and neighboring residences. Certain houses with high transmission risk contribute disproportionately to DENV spread to neighboring houses. Small groups of houses with elevated transmission risk are consistent with over-dispersion of transmission (i.e., at a given point in time, people/mosquitoes from ... |
format |
Article in Journal/Newspaper |
author |
In-Kyu Yoon Arthur Getis Jared Aldstadt Alan L Rothman Darunee Tannitisupawong Constantianus J M Koenraadt Thanyalak Fansiri James W Jones Amy C Morrison Richard G Jarman Ananda Nisalak Mammen P Mammen Suwich Thammapalo Anon Srikiatkhachorn Sharone Green Daniel H Libraty Robert V Gibbons Timothy Endy Chusak Pimgate Thomas W Scott |
author_facet |
In-Kyu Yoon Arthur Getis Jared Aldstadt Alan L Rothman Darunee Tannitisupawong Constantianus J M Koenraadt Thanyalak Fansiri James W Jones Amy C Morrison Richard G Jarman Ananda Nisalak Mammen P Mammen Suwich Thammapalo Anon Srikiatkhachorn Sharone Green Daniel H Libraty Robert V Gibbons Timothy Endy Chusak Pimgate Thomas W Scott |
author_sort |
In-Kyu Yoon |
title |
Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages. |
title_short |
Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages. |
title_full |
Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages. |
title_fullStr |
Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages. |
title_full_unstemmed |
Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages. |
title_sort |
fine scale spatiotemporal clustering of dengue virus transmission in children and aedes aegypti in rural thai villages. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001730 https://doaj.org/article/d8542e1605974b54bef2e0a984e53f97 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1730 (2012) |
op_relation |
http://europepmc.org/articles/PMC3398976?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001730 https://doaj.org/article/d8542e1605974b54bef2e0a984e53f97 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001730 |
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PLoS Neglected Tropical Diseases |
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6 |
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7 |
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e1730 |
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1766344832042663936 |