Tratamento da cisticercose subcutânea co praziquantel: um novo agente cestoidicida
Twenty adult patients presenting dermal cysticercosis without cerebral or ocular involvement were treated with praziquantel. The first eleven cases received 60 mg/kg/day and the last nine cases 30 mg/kg/day. In both groups the daily dose was split into three oral intakes 4 to 6 hours apart and the d...
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Universidade de São Paulo (USP)
1984
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Online Access: | https://doi.org/10.1590/S0036-46651984000500006 https://doaj.org/article/d847ada187314187a8d7985595404dfc |
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ftdoajarticles:oai:doaj.org/article:d847ada187314187a8d7985595404dfc 2024-09-09T19:25:36+00:00 Tratamento da cisticercose subcutânea co praziquantel: um novo agente cestoidicida Miroslau Constante Baranski 1984-10-01T00:00:00Z https://doi.org/10.1590/S0036-46651984000500006 https://doaj.org/article/d847ada187314187a8d7985595404dfc EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651984000500006&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46651984000500006 https://doaj.org/article/d847ada187314187a8d7985595404dfc Revista do Instituto de Medicina Tropical de São Paulo, Vol 26, Iss 5, Pp 259-266 (1984) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1984 ftdoajarticles https://doi.org/10.1590/S0036-46651984000500006 2024-08-05T17:49:30Z Twenty adult patients presenting dermal cysticercosis without cerebral or ocular involvement were treated with praziquantel. The first eleven cases received 60 mg/kg/day and the last nine cases 30 mg/kg/day. In both groups the daily dose was split into three oral intakes 4 to 6 hours apart and the drug administration lasted for 6 consecutive days. The latter group of patients also got dexamethasone, 3 mg daily, from one day before until four days after the treatment period with praziquantel. The drug proved to be 100% efficacious as demonstrated histopathologically by the death of the cysticerci of Taenia solium (Cysticercus cellulosae) in serial biopsies taken from the 2nd week on after the end of treatment, as well as clinically by the steady disappearence of the dermal nodules during the 6 months following the therapy. Tolerance of praziquantel was good as the incidence and severity of side-effects were not relevant. The drug safety was confirmed through laboratory tests which failed to detect any abnormal findings related to the hematopoietic, liver and kidney functions. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 26 5 259 266 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Miroslau Constante Baranski Tratamento da cisticercose subcutânea co praziquantel: um novo agente cestoidicida |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Twenty adult patients presenting dermal cysticercosis without cerebral or ocular involvement were treated with praziquantel. The first eleven cases received 60 mg/kg/day and the last nine cases 30 mg/kg/day. In both groups the daily dose was split into three oral intakes 4 to 6 hours apart and the drug administration lasted for 6 consecutive days. The latter group of patients also got dexamethasone, 3 mg daily, from one day before until four days after the treatment period with praziquantel. The drug proved to be 100% efficacious as demonstrated histopathologically by the death of the cysticerci of Taenia solium (Cysticercus cellulosae) in serial biopsies taken from the 2nd week on after the end of treatment, as well as clinically by the steady disappearence of the dermal nodules during the 6 months following the therapy. Tolerance of praziquantel was good as the incidence and severity of side-effects were not relevant. The drug safety was confirmed through laboratory tests which failed to detect any abnormal findings related to the hematopoietic, liver and kidney functions. |
format |
Article in Journal/Newspaper |
author |
Miroslau Constante Baranski |
author_facet |
Miroslau Constante Baranski |
author_sort |
Miroslau Constante Baranski |
title |
Tratamento da cisticercose subcutânea co praziquantel: um novo agente cestoidicida |
title_short |
Tratamento da cisticercose subcutânea co praziquantel: um novo agente cestoidicida |
title_full |
Tratamento da cisticercose subcutânea co praziquantel: um novo agente cestoidicida |
title_fullStr |
Tratamento da cisticercose subcutânea co praziquantel: um novo agente cestoidicida |
title_full_unstemmed |
Tratamento da cisticercose subcutânea co praziquantel: um novo agente cestoidicida |
title_sort |
tratamento da cisticercose subcutânea co praziquantel: um novo agente cestoidicida |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1984 |
url |
https://doi.org/10.1590/S0036-46651984000500006 https://doaj.org/article/d847ada187314187a8d7985595404dfc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 26, Iss 5, Pp 259-266 (1984) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651984000500006&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46651984000500006 https://doaj.org/article/d847ada187314187a8d7985595404dfc |
op_doi |
https://doi.org/10.1590/S0036-46651984000500006 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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26 |
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5 |
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259 |
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266 |
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