Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy
Objective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy. Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations against Plasmodium berghei berghei was evaluated u...
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ftdoajarticles:oai:doaj.org/article:d809b1a5caf4440d97ed0e0a0bb0ba4f 2023-05-15T15:05:56+02:00 Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy Peace Mayen Edwin Ubulom Chinweizu Ejikeme Udobi Mark Iheukwumere Madu 2015-01-01T00:00:00Z https://doi.org/10.1155/2015/947390 https://doaj.org/article/d809b1a5caf4440d97ed0e0a0bb0ba4f EN eng Hindawi Limited http://dx.doi.org/10.1155/2015/947390 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2015/947390 https://doaj.org/article/d809b1a5caf4440d97ed0e0a0bb0ba4f Journal of Tropical Medicine, Vol 2015 (2015) Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.1155/2015/947390 2022-12-31T15:52:11Z Objective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy. Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations against Plasmodium berghei berghei was evaluated using Swiss albino mice. Results. Amodiaquine (a known antiplasmodial agent) had a fairly significant antiplasmodial effect reducing the parasites for every 100 red blood cells (RBC) from 66 to 16 (75.75%) at the tolerable dosage level of 7.5 mg/kg body weight while Ciprofloxacin (an antibiotic known to have antimalarial effect) showed an insignificant antiplasmodial effect reducing the parasites for every 100 RBC from 65 to 64 (1.53%) at the tolerable dosage level of 10.7 mg/kg body weight. Conversely, the combination therapy of Amodiaquine and Ciprofloxacin had a significant antiplasmodial effect at all the doses administered. The combination of 7.5 mg/kg of Amodiaquine and 12.8 mg/kg of Ciprofloxacin, however, showed the most significant antiplasmodial effect of the doses used reducing the number of parasites per 100 RBC from 60 to 10 (83.33%). Conclusions. Appropriate Amodiaquine and Ciprofloxacin combination will be effective for the treatment of malaria and better than either Amodiaquine or Ciprofloxacin singly at their recommended dosage levels. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2015 1 4 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Peace Mayen Edwin Ubulom Chinweizu Ejikeme Udobi Mark Iheukwumere Madu Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Objective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy. Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations against Plasmodium berghei berghei was evaluated using Swiss albino mice. Results. Amodiaquine (a known antiplasmodial agent) had a fairly significant antiplasmodial effect reducing the parasites for every 100 red blood cells (RBC) from 66 to 16 (75.75%) at the tolerable dosage level of 7.5 mg/kg body weight while Ciprofloxacin (an antibiotic known to have antimalarial effect) showed an insignificant antiplasmodial effect reducing the parasites for every 100 RBC from 65 to 64 (1.53%) at the tolerable dosage level of 10.7 mg/kg body weight. Conversely, the combination therapy of Amodiaquine and Ciprofloxacin had a significant antiplasmodial effect at all the doses administered. The combination of 7.5 mg/kg of Amodiaquine and 12.8 mg/kg of Ciprofloxacin, however, showed the most significant antiplasmodial effect of the doses used reducing the number of parasites per 100 RBC from 60 to 10 (83.33%). Conclusions. Appropriate Amodiaquine and Ciprofloxacin combination will be effective for the treatment of malaria and better than either Amodiaquine or Ciprofloxacin singly at their recommended dosage levels. |
format |
Article in Journal/Newspaper |
author |
Peace Mayen Edwin Ubulom Chinweizu Ejikeme Udobi Mark Iheukwumere Madu |
author_facet |
Peace Mayen Edwin Ubulom Chinweizu Ejikeme Udobi Mark Iheukwumere Madu |
author_sort |
Peace Mayen Edwin Ubulom |
title |
Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy |
title_short |
Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy |
title_full |
Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy |
title_fullStr |
Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy |
title_full_unstemmed |
Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy |
title_sort |
amodiaquine and ciprofloxacin combination in plasmodiasis therapy |
publisher |
Hindawi Limited |
publishDate |
2015 |
url |
https://doi.org/10.1155/2015/947390 https://doaj.org/article/d809b1a5caf4440d97ed0e0a0bb0ba4f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2015 (2015) |
op_relation |
http://dx.doi.org/10.1155/2015/947390 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2015/947390 https://doaj.org/article/d809b1a5caf4440d97ed0e0a0bb0ba4f |
op_doi |
https://doi.org/10.1155/2015/947390 |
container_title |
Journal of Tropical Medicine |
container_volume |
2015 |
container_start_page |
1 |
op_container_end_page |
4 |
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1766337619804815360 |