Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population.

Background The prevalence of Strongyloides stercoralis infection is estimated to be 30-100 million worldwide, although this an underestimate. Most cases remain undiagnosed due to the asymptomatic nature of the infection. We wanted to estimate the seroprevalence of S. stercoralis infection in a South...

Full description

Bibliographic Details
Published in:PLOS Neglected Tropical Diseases
Main Authors: Saravanan Munisankar, Anuradha Rajamanickam, Suganthi Balasubramanian, Satishwaran Muthusamy, Chandra Kumar Dolla, Pradeep Aravindan Menon, Ponnuraja Chinnayan, Christopher Whalen, Paschaline Gumne, Inderdeep Kaur, Varma Nadimpalli, Akshay Deverakonda, Zhenhao Chen, John David Otto, Tesfalidet Habitegiyorgis, Harish Kandaswamy, Thomas B Nutman, Subash Babu
Format: Article in Journal/Newspaper
Language:English
Published: Public Library of Science (PLoS) 2022
Subjects:
Online Access:https://doi.org/10.1371/journal.pntd.0010561
https://doaj.org/article/d7fc1da6a5a34e098cbc5d7869bb67d0
id ftdoajarticles:oai:doaj.org/article:d7fc1da6a5a34e098cbc5d7869bb67d0
record_format openpolar
spelling ftdoajarticles:oai:doaj.org/article:d7fc1da6a5a34e098cbc5d7869bb67d0 2023-05-15T15:08:55+02:00 Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population. Saravanan Munisankar Anuradha Rajamanickam Suganthi Balasubramanian Satishwaran Muthusamy Chandra Kumar Dolla Pradeep Aravindan Menon Ponnuraja Chinnayan Christopher Whalen Paschaline Gumne Inderdeep Kaur Varma Nadimpalli Akshay Deverakonda Zhenhao Chen John David Otto Tesfalidet Habitegiyorgis Harish Kandaswamy Thomas B Nutman Subash Babu 2022-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010561 https://doaj.org/article/d7fc1da6a5a34e098cbc5d7869bb67d0 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010561 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010561 https://doaj.org/article/d7fc1da6a5a34e098cbc5d7869bb67d0 PLoS Neglected Tropical Diseases, Vol 16, Iss 7, p e0010561 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010561 2022-12-30T22:15:52Z Background The prevalence of Strongyloides stercoralis infection is estimated to be 30-100 million worldwide, although this an underestimate. Most cases remain undiagnosed due to the asymptomatic nature of the infection. We wanted to estimate the seroprevalence of S. stercoralis infection in a South Indian adult population. Methods To this end, we performed community-based screening of 2351 individuals (aged 18-65) in Kanchipuram District of Tamil Nadu between 2013 and 2020. Serological testing for S. stercoralis was performed using the NIE ELISA. Results Our data shows a seroprevalence of 33% (768/2351) for S. stercoralis infection which had a higher prevalence among males 36% (386/1069) than among females 29.8% (382/1282). Adults aged ≥55 (aOR = 1.65, 95% CI: 1.25-2.18) showed higher adjusted odds of association compared with other age groups. Eosinophil levels (39%) (aOR = 1.43, 95% CI: 1.19-1.74) and hemoglobin levels (24%) (aOR = 1.25, 95% CI: 1.11-1.53) were significantly associated with S. stercoralis infection. In contrast, low BMI (aOR = 1.15, 95% CI: 0.82-1.61) or the presence of diabetes mellitus (OR = 1.18, 95% CI: 0.83-1.69) was not associated with S. stercoralis seropositivity. Conclusions Our study provides evidence for a very high baseline prevalence of S. stercoralis infection in South Indian communities and this information could provide realistic and concrete planning of control measures. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Indian PLOS Neglected Tropical Diseases 16 7 e0010561
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
spellingShingle Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Saravanan Munisankar
Anuradha Rajamanickam
Suganthi Balasubramanian
Satishwaran Muthusamy
Chandra Kumar Dolla
Pradeep Aravindan Menon
Ponnuraja Chinnayan
Christopher Whalen
Paschaline Gumne
Inderdeep Kaur
Varma Nadimpalli
Akshay Deverakonda
Zhenhao Chen
John David Otto
Tesfalidet Habitegiyorgis
Harish Kandaswamy
Thomas B Nutman
Subash Babu
Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population.
topic_facet Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
description Background The prevalence of Strongyloides stercoralis infection is estimated to be 30-100 million worldwide, although this an underestimate. Most cases remain undiagnosed due to the asymptomatic nature of the infection. We wanted to estimate the seroprevalence of S. stercoralis infection in a South Indian adult population. Methods To this end, we performed community-based screening of 2351 individuals (aged 18-65) in Kanchipuram District of Tamil Nadu between 2013 and 2020. Serological testing for S. stercoralis was performed using the NIE ELISA. Results Our data shows a seroprevalence of 33% (768/2351) for S. stercoralis infection which had a higher prevalence among males 36% (386/1069) than among females 29.8% (382/1282). Adults aged ≥55 (aOR = 1.65, 95% CI: 1.25-2.18) showed higher adjusted odds of association compared with other age groups. Eosinophil levels (39%) (aOR = 1.43, 95% CI: 1.19-1.74) and hemoglobin levels (24%) (aOR = 1.25, 95% CI: 1.11-1.53) were significantly associated with S. stercoralis infection. In contrast, low BMI (aOR = 1.15, 95% CI: 0.82-1.61) or the presence of diabetes mellitus (OR = 1.18, 95% CI: 0.83-1.69) was not associated with S. stercoralis seropositivity. Conclusions Our study provides evidence for a very high baseline prevalence of S. stercoralis infection in South Indian communities and this information could provide realistic and concrete planning of control measures.
format Article in Journal/Newspaper
author Saravanan Munisankar
Anuradha Rajamanickam
Suganthi Balasubramanian
Satishwaran Muthusamy
Chandra Kumar Dolla
Pradeep Aravindan Menon
Ponnuraja Chinnayan
Christopher Whalen
Paschaline Gumne
Inderdeep Kaur
Varma Nadimpalli
Akshay Deverakonda
Zhenhao Chen
John David Otto
Tesfalidet Habitegiyorgis
Harish Kandaswamy
Thomas B Nutman
Subash Babu
author_facet Saravanan Munisankar
Anuradha Rajamanickam
Suganthi Balasubramanian
Satishwaran Muthusamy
Chandra Kumar Dolla
Pradeep Aravindan Menon
Ponnuraja Chinnayan
Christopher Whalen
Paschaline Gumne
Inderdeep Kaur
Varma Nadimpalli
Akshay Deverakonda
Zhenhao Chen
John David Otto
Tesfalidet Habitegiyorgis
Harish Kandaswamy
Thomas B Nutman
Subash Babu
author_sort Saravanan Munisankar
title Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population.
title_short Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population.
title_full Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population.
title_fullStr Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population.
title_full_unstemmed Seroprevalence of Strongyloides stercoralis infection in a South Indian adult population.
title_sort seroprevalence of strongyloides stercoralis infection in a south indian adult population.
publisher Public Library of Science (PLoS)
publishDate 2022
url https://doi.org/10.1371/journal.pntd.0010561
https://doaj.org/article/d7fc1da6a5a34e098cbc5d7869bb67d0
geographic Arctic
Indian
geographic_facet Arctic
Indian
genre Arctic
genre_facet Arctic
op_source PLoS Neglected Tropical Diseases, Vol 16, Iss 7, p e0010561 (2022)
op_relation https://doi.org/10.1371/journal.pntd.0010561
https://doaj.org/toc/1935-2727
https://doaj.org/toc/1935-2735
1935-2727
1935-2735
doi:10.1371/journal.pntd.0010561
https://doaj.org/article/d7fc1da6a5a34e098cbc5d7869bb67d0
op_doi https://doi.org/10.1371/journal.pntd.0010561
container_title PLOS Neglected Tropical Diseases
container_volume 16
container_issue 7
container_start_page e0010561
_version_ 1766340181306114048