Interchanging Reusable and Disposable Nebulizers Used with Home-Based Compressors May Result in Inconsistent Dosing: A Laboratory Investigation with Device Combinations Supplied to the US Healthcare Environment
Abstract Introduction Reusable nebulizer–compressor combinations deliver inhaled medications for patients with chronic lung diseases. On hospital discharge, the patient may take home the disposable nebulizer that was packaged and combine it with their home compressor. Though this practice may reduce...
Published in: | Pulmonary Therapy |
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Adis, Springer Healthcare
2024
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Online Access: | https://doi.org/10.1007/s41030-024-00256-0 https://doaj.org/article/d7a8fa545a594e96b6ebc02d3ebdfc53 |
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ftdoajarticles:oai:doaj.org/article:d7a8fa545a594e96b6ebc02d3ebdfc53 2024-09-15T18:33:48+00:00 Interchanging Reusable and Disposable Nebulizers Used with Home-Based Compressors May Result in Inconsistent Dosing: A Laboratory Investigation with Device Combinations Supplied to the US Healthcare Environment Judy Schloss Dominic P. Coppolo Jason A. Suggett Mark W. Nagel Jolyon P. Mitchell 2024-04-01T00:00:00Z https://doi.org/10.1007/s41030-024-00256-0 https://doaj.org/article/d7a8fa545a594e96b6ebc02d3ebdfc53 EN eng Adis, Springer Healthcare https://doi.org/10.1007/s41030-024-00256-0 https://doaj.org/toc/2364-1754 https://doaj.org/toc/2364-1746 doi:10.1007/s41030-024-00256-0 2364-1754 2364-1746 https://doaj.org/article/d7a8fa545a594e96b6ebc02d3ebdfc53 Pulmonary Therapy, Vol 10, Iss 2, Pp 207-224 (2024) Jet nebulizer Compressor Medication delivery Drug delivery variability Diseases of the respiratory system RC705-779 article 2024 ftdoajarticles https://doi.org/10.1007/s41030-024-00256-0 2024-08-05T17:48:49Z Abstract Introduction Reusable nebulizer–compressor combinations deliver inhaled medications for patients with chronic lung diseases. On hospital discharge, the patient may take home the disposable nebulizer that was packaged and combine it with their home compressor. Though this practice may reduce waste, it can increase variability in medication delivery. Our study compared several reusable and disposable nebulizers packaged with compressor kits used in the US. We included a common disposable hospital nebulizer that may not be supplied with popular home kits but may be brought home after a hospitalization or emergency department visit. We focused on fine droplet mass < 4.7 μm aerodynamic diameter (FDM<4.7 μm), associated with medication delivery to the airways of the lungs. Methods We evaluated the following nebulizer–compressor combinations (n = 5 replicates): 1. OMBRA® Table Top Compressor with MC 300® reusable and Airlife™ MistyMax™ 10® disposable nebulizer, 2. Sami-the-Seal® compressor with SideStream® reusable and disposable nebulizers and Airlife™ MistyMax 10™ disposable nebulizer, 3. VIOS® compressor with LC Sprint® reusable, and VixOne® and Airlife™ MistyMax™ disposable nebulizers, 4. Innospire® Elegance® compressor with SideStream® reusable and disposable nebulizers and Airlife™ MistyMax 10™ disposable nebulizer, 5. Willis-the-Whale® compressor with SideStream® reusable and disposable nebulizers and Airlife™ MistyMax 10™ disposable nebulizer, 6. Pari PRONEB® Max compressor with LC Sprint® reusable and Airlife™ MistyMax 10™ disposable nebulizer. We placed a 3-ml albuterol solution (0.833 mg/ml) in each nebulizer. A bacterial/viral filter was attached to the nebulizer mouthpiece to capture emitted medication, with the filter exit coupled to a simulator of a tidal breathing adult (rate = 10 cycles/min; V t = 600 ml; I/E ratio = 1:2). The filter was replaced at 1-min intervals until onset of sputter. Droplet size distributions (n = 5 replicates/system) were determined in parallel by laser ... Article in Journal/Newspaper sami Directory of Open Access Journals: DOAJ Articles Pulmonary Therapy 10 2 207 224 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Jet nebulizer Compressor Medication delivery Drug delivery variability Diseases of the respiratory system RC705-779 |
spellingShingle |
Jet nebulizer Compressor Medication delivery Drug delivery variability Diseases of the respiratory system RC705-779 Judy Schloss Dominic P. Coppolo Jason A. Suggett Mark W. Nagel Jolyon P. Mitchell Interchanging Reusable and Disposable Nebulizers Used with Home-Based Compressors May Result in Inconsistent Dosing: A Laboratory Investigation with Device Combinations Supplied to the US Healthcare Environment |
topic_facet |
Jet nebulizer Compressor Medication delivery Drug delivery variability Diseases of the respiratory system RC705-779 |
description |
Abstract Introduction Reusable nebulizer–compressor combinations deliver inhaled medications for patients with chronic lung diseases. On hospital discharge, the patient may take home the disposable nebulizer that was packaged and combine it with their home compressor. Though this practice may reduce waste, it can increase variability in medication delivery. Our study compared several reusable and disposable nebulizers packaged with compressor kits used in the US. We included a common disposable hospital nebulizer that may not be supplied with popular home kits but may be brought home after a hospitalization or emergency department visit. We focused on fine droplet mass < 4.7 μm aerodynamic diameter (FDM<4.7 μm), associated with medication delivery to the airways of the lungs. Methods We evaluated the following nebulizer–compressor combinations (n = 5 replicates): 1. OMBRA® Table Top Compressor with MC 300® reusable and Airlife™ MistyMax™ 10® disposable nebulizer, 2. Sami-the-Seal® compressor with SideStream® reusable and disposable nebulizers and Airlife™ MistyMax 10™ disposable nebulizer, 3. VIOS® compressor with LC Sprint® reusable, and VixOne® and Airlife™ MistyMax™ disposable nebulizers, 4. Innospire® Elegance® compressor with SideStream® reusable and disposable nebulizers and Airlife™ MistyMax 10™ disposable nebulizer, 5. Willis-the-Whale® compressor with SideStream® reusable and disposable nebulizers and Airlife™ MistyMax 10™ disposable nebulizer, 6. Pari PRONEB® Max compressor with LC Sprint® reusable and Airlife™ MistyMax 10™ disposable nebulizer. We placed a 3-ml albuterol solution (0.833 mg/ml) in each nebulizer. A bacterial/viral filter was attached to the nebulizer mouthpiece to capture emitted medication, with the filter exit coupled to a simulator of a tidal breathing adult (rate = 10 cycles/min; V t = 600 ml; I/E ratio = 1:2). The filter was replaced at 1-min intervals until onset of sputter. Droplet size distributions (n = 5 replicates/system) were determined in parallel by laser ... |
format |
Article in Journal/Newspaper |
author |
Judy Schloss Dominic P. Coppolo Jason A. Suggett Mark W. Nagel Jolyon P. Mitchell |
author_facet |
Judy Schloss Dominic P. Coppolo Jason A. Suggett Mark W. Nagel Jolyon P. Mitchell |
author_sort |
Judy Schloss |
title |
Interchanging Reusable and Disposable Nebulizers Used with Home-Based Compressors May Result in Inconsistent Dosing: A Laboratory Investigation with Device Combinations Supplied to the US Healthcare Environment |
title_short |
Interchanging Reusable and Disposable Nebulizers Used with Home-Based Compressors May Result in Inconsistent Dosing: A Laboratory Investigation with Device Combinations Supplied to the US Healthcare Environment |
title_full |
Interchanging Reusable and Disposable Nebulizers Used with Home-Based Compressors May Result in Inconsistent Dosing: A Laboratory Investigation with Device Combinations Supplied to the US Healthcare Environment |
title_fullStr |
Interchanging Reusable and Disposable Nebulizers Used with Home-Based Compressors May Result in Inconsistent Dosing: A Laboratory Investigation with Device Combinations Supplied to the US Healthcare Environment |
title_full_unstemmed |
Interchanging Reusable and Disposable Nebulizers Used with Home-Based Compressors May Result in Inconsistent Dosing: A Laboratory Investigation with Device Combinations Supplied to the US Healthcare Environment |
title_sort |
interchanging reusable and disposable nebulizers used with home-based compressors may result in inconsistent dosing: a laboratory investigation with device combinations supplied to the us healthcare environment |
publisher |
Adis, Springer Healthcare |
publishDate |
2024 |
url |
https://doi.org/10.1007/s41030-024-00256-0 https://doaj.org/article/d7a8fa545a594e96b6ebc02d3ebdfc53 |
genre |
sami |
genre_facet |
sami |
op_source |
Pulmonary Therapy, Vol 10, Iss 2, Pp 207-224 (2024) |
op_relation |
https://doi.org/10.1007/s41030-024-00256-0 https://doaj.org/toc/2364-1754 https://doaj.org/toc/2364-1746 doi:10.1007/s41030-024-00256-0 2364-1754 2364-1746 https://doaj.org/article/d7a8fa545a594e96b6ebc02d3ebdfc53 |
op_doi |
https://doi.org/10.1007/s41030-024-00256-0 |
container_title |
Pulmonary Therapy |
container_volume |
10 |
container_issue |
2 |
container_start_page |
207 |
op_container_end_page |
224 |
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