Multiple FGF4 Retrocopies Recently Derived within Canids
Two transcribed retrocopies of the fibroblast growth factor 4 ( FGF4 ) gene have previously been described in the domestic dog. An FGF4 retrocopy on chr18 is associated with disproportionate dwarfism, while an FGF4 retrocopy on chr12 is associated with both disproportionate dwarfism and intervertebr...
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ftdoajarticles:oai:doaj.org/article:d7924ac3888c4c2085c081c04e76decc 2023-05-15T15:50:20+02:00 Multiple FGF4 Retrocopies Recently Derived within Canids Kevin Batcher Peter Dickinson Kimberly Maciejczyk Kristin Brzeski Sheida Hadji Rasouliha Anna Letko Cord Drögemüller Tosso Leeb Danika Bannasch 2020-07-01T00:00:00Z https://doi.org/10.3390/genes11080839 https://doaj.org/article/d7924ac3888c4c2085c081c04e76decc EN eng MDPI AG https://www.mdpi.com/2073-4425/11/8/839 https://doaj.org/toc/2073-4425 doi:10.3390/genes11080839 2073-4425 https://doaj.org/article/d7924ac3888c4c2085c081c04e76decc Genes, Vol 11, Iss 839, p 839 (2020) Canis lupus familiaris FGF4 retrocopy retrogene pseudogene retrotransposition Genetics QH426-470 article 2020 ftdoajarticles https://doi.org/10.3390/genes11080839 2022-12-31T02:00:14Z Two transcribed retrocopies of the fibroblast growth factor 4 ( FGF4 ) gene have previously been described in the domestic dog. An FGF4 retrocopy on chr18 is associated with disproportionate dwarfism, while an FGF4 retrocopy on chr12 is associated with both disproportionate dwarfism and intervertebral disc disease (IVDD). In this study, whole-genome sequencing data were queried to identify other FGF4 retrocopies that could be contributing to phenotypic diversity in canids. Additionally, dogs with surgically confirmed IVDD were assayed for novel FGF4 retrocopies. Five additional and distinct FGF4 retrocopies were identified in canids including a copy unique to red wolves ( Canis rufus ). The FGF4 retrocopies identified in domestic dogs were identical to domestic dog FGF4 haplotypes, which are distinct from modern wolf FGF4 haplotypes, indicating that these retrotransposition events likely occurred after domestication. The identification of multiple, full length FGF4 retrocopies with open reading frames in canids indicates that gene retrotransposition events occur much more frequently than previously thought and provide a mechanism for continued genetic and phenotypic diversity in canids. Article in Journal/Newspaper Canis lupus Directory of Open Access Journals: DOAJ Articles Genes 11 8 839 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Canis lupus familiaris FGF4 retrocopy retrogene pseudogene retrotransposition Genetics QH426-470 |
spellingShingle |
Canis lupus familiaris FGF4 retrocopy retrogene pseudogene retrotransposition Genetics QH426-470 Kevin Batcher Peter Dickinson Kimberly Maciejczyk Kristin Brzeski Sheida Hadji Rasouliha Anna Letko Cord Drögemüller Tosso Leeb Danika Bannasch Multiple FGF4 Retrocopies Recently Derived within Canids |
topic_facet |
Canis lupus familiaris FGF4 retrocopy retrogene pseudogene retrotransposition Genetics QH426-470 |
description |
Two transcribed retrocopies of the fibroblast growth factor 4 ( FGF4 ) gene have previously been described in the domestic dog. An FGF4 retrocopy on chr18 is associated with disproportionate dwarfism, while an FGF4 retrocopy on chr12 is associated with both disproportionate dwarfism and intervertebral disc disease (IVDD). In this study, whole-genome sequencing data were queried to identify other FGF4 retrocopies that could be contributing to phenotypic diversity in canids. Additionally, dogs with surgically confirmed IVDD were assayed for novel FGF4 retrocopies. Five additional and distinct FGF4 retrocopies were identified in canids including a copy unique to red wolves ( Canis rufus ). The FGF4 retrocopies identified in domestic dogs were identical to domestic dog FGF4 haplotypes, which are distinct from modern wolf FGF4 haplotypes, indicating that these retrotransposition events likely occurred after domestication. The identification of multiple, full length FGF4 retrocopies with open reading frames in canids indicates that gene retrotransposition events occur much more frequently than previously thought and provide a mechanism for continued genetic and phenotypic diversity in canids. |
format |
Article in Journal/Newspaper |
author |
Kevin Batcher Peter Dickinson Kimberly Maciejczyk Kristin Brzeski Sheida Hadji Rasouliha Anna Letko Cord Drögemüller Tosso Leeb Danika Bannasch |
author_facet |
Kevin Batcher Peter Dickinson Kimberly Maciejczyk Kristin Brzeski Sheida Hadji Rasouliha Anna Letko Cord Drögemüller Tosso Leeb Danika Bannasch |
author_sort |
Kevin Batcher |
title |
Multiple FGF4 Retrocopies Recently Derived within Canids |
title_short |
Multiple FGF4 Retrocopies Recently Derived within Canids |
title_full |
Multiple FGF4 Retrocopies Recently Derived within Canids |
title_fullStr |
Multiple FGF4 Retrocopies Recently Derived within Canids |
title_full_unstemmed |
Multiple FGF4 Retrocopies Recently Derived within Canids |
title_sort |
multiple fgf4 retrocopies recently derived within canids |
publisher |
MDPI AG |
publishDate |
2020 |
url |
https://doi.org/10.3390/genes11080839 https://doaj.org/article/d7924ac3888c4c2085c081c04e76decc |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Genes, Vol 11, Iss 839, p 839 (2020) |
op_relation |
https://www.mdpi.com/2073-4425/11/8/839 https://doaj.org/toc/2073-4425 doi:10.3390/genes11080839 2073-4425 https://doaj.org/article/d7924ac3888c4c2085c081c04e76decc |
op_doi |
https://doi.org/10.3390/genes11080839 |
container_title |
Genes |
container_volume |
11 |
container_issue |
8 |
container_start_page |
839 |
_version_ |
1766385299953287168 |