The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales
To compare gene loci considering a phylogenetic framework is a promising approach to uncover the genetic basis of human diseases. Imbalance of dopaminergic systems is suspected to underlie some emerging neurological disorders. The physiological functions of dopamine are transduced via G-protein-coup...
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ftdoajarticles:oai:doaj.org/article:d787861b41244140aa6aa26bcdefdbeb 2024-01-07T09:42:22+01:00 The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales Luís Q. Alves Juliana Alves Rodrigo Ribeiro Raquel Ruivo Filipe Castro 2019-10-01T00:00:00Z https://doi.org/10.7717/peerj.7758 https://doaj.org/article/d787861b41244140aa6aa26bcdefdbeb EN eng PeerJ Inc. https://peerj.com/articles/7758.pdf https://peerj.com/articles/7758/ https://doaj.org/toc/2167-8359 doi:10.7717/peerj.7758 2167-8359 https://doaj.org/article/d787861b41244140aa6aa26bcdefdbeb PeerJ, Vol 7, p e7758 (2019) Gene loss Dopamine Cetacea Sleep Hypertension Medicine R Biology (General) QH301-705.5 article 2019 ftdoajarticles https://doi.org/10.7717/peerj.7758 2023-12-10T01:50:41Z To compare gene loci considering a phylogenetic framework is a promising approach to uncover the genetic basis of human diseases. Imbalance of dopaminergic systems is suspected to underlie some emerging neurological disorders. The physiological functions of dopamine are transduced via G-protein-coupled receptors, including DRD5 which displays a relatively higher affinity toward dopamine. Importantly, DRD5 knockout mice are hypertense, a condition emerging from an increase in sympathetic tone. We investigated the evolution of DRD5, a high affinity receptor for dopamine, in mammals. Surprisingly, among 124 investigated mammalian genomes, we found that Cetacea lineages (Mysticeti and Odontoceti) have independently lost this gene, as well as the burrowing Chrysochloris asiatica (Cape golden mole). We suggest that DRD5 inactivation parallels hypoxia-induced adaptations, such as peripheral vasoconstriction required for deep-diving in Cetacea, in accordance with the convergent evolution of vasoconstrictor genes in hypoxia-exposed animals. Our findings indicate that Cetacea are natural knockouts for DRD5 and might offer valuable insights into the mechanisms of some forms of vasoconstriction responses and hypertension in humans. Article in Journal/Newspaper baleen whales Directory of Open Access Journals: DOAJ Articles PeerJ 7 e7758 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Gene loss Dopamine Cetacea Sleep Hypertension Medicine R Biology (General) QH301-705.5 |
spellingShingle |
Gene loss Dopamine Cetacea Sleep Hypertension Medicine R Biology (General) QH301-705.5 Luís Q. Alves Juliana Alves Rodrigo Ribeiro Raquel Ruivo Filipe Castro The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales |
topic_facet |
Gene loss Dopamine Cetacea Sleep Hypertension Medicine R Biology (General) QH301-705.5 |
description |
To compare gene loci considering a phylogenetic framework is a promising approach to uncover the genetic basis of human diseases. Imbalance of dopaminergic systems is suspected to underlie some emerging neurological disorders. The physiological functions of dopamine are transduced via G-protein-coupled receptors, including DRD5 which displays a relatively higher affinity toward dopamine. Importantly, DRD5 knockout mice are hypertense, a condition emerging from an increase in sympathetic tone. We investigated the evolution of DRD5, a high affinity receptor for dopamine, in mammals. Surprisingly, among 124 investigated mammalian genomes, we found that Cetacea lineages (Mysticeti and Odontoceti) have independently lost this gene, as well as the burrowing Chrysochloris asiatica (Cape golden mole). We suggest that DRD5 inactivation parallels hypoxia-induced adaptations, such as peripheral vasoconstriction required for deep-diving in Cetacea, in accordance with the convergent evolution of vasoconstrictor genes in hypoxia-exposed animals. Our findings indicate that Cetacea are natural knockouts for DRD5 and might offer valuable insights into the mechanisms of some forms of vasoconstriction responses and hypertension in humans. |
format |
Article in Journal/Newspaper |
author |
Luís Q. Alves Juliana Alves Rodrigo Ribeiro Raquel Ruivo Filipe Castro |
author_facet |
Luís Q. Alves Juliana Alves Rodrigo Ribeiro Raquel Ruivo Filipe Castro |
author_sort |
Luís Q. Alves |
title |
The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales |
title_short |
The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales |
title_full |
The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales |
title_fullStr |
The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales |
title_full_unstemmed |
The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales |
title_sort |
dopamine receptor d5 gene shows signs of independent erosion in toothed and baleen whales |
publisher |
PeerJ Inc. |
publishDate |
2019 |
url |
https://doi.org/10.7717/peerj.7758 https://doaj.org/article/d787861b41244140aa6aa26bcdefdbeb |
genre |
baleen whales |
genre_facet |
baleen whales |
op_source |
PeerJ, Vol 7, p e7758 (2019) |
op_relation |
https://peerj.com/articles/7758.pdf https://peerj.com/articles/7758/ https://doaj.org/toc/2167-8359 doi:10.7717/peerj.7758 2167-8359 https://doaj.org/article/d787861b41244140aa6aa26bcdefdbeb |
op_doi |
https://doi.org/10.7717/peerj.7758 |
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PeerJ |
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7 |
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e7758 |
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1787423324960194560 |