Cost-effectiveness of childhood hepatitis A vaccination in Argentina: a second dose is warranted Efectividad en función del costo de la vacunación infantil contra la hepatitis A en Argentina: se justifica una segunda dosis
OBJECTIVES: To investigate the cost-effectiveness of childhood vaccination against hepatitis A in the five geographic regions of Argentina, and to determine whether adding a second dose to the current one-dose schedule would provide health gains justifying its added cost. METHODS: A Markov model was...
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Pan American Health Organization
2007
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ftdoajarticles:oai:doaj.org/article:d75a8b56c4c3407cae6253f1d4c6c467 2023-05-15T15:19:27+02:00 Cost-effectiveness of childhood hepatitis A vaccination in Argentina: a second dose is warranted Efectividad en función del costo de la vacunación infantil contra la hepatitis A en Argentina: se justifica una segunda dosis Alejandro Ellis Ricardo W. Rüttimann R. Jake Jacobs Allen S. Meyerhoff Bruce L. Innis 2007-06-01T00:00:00Z https://doaj.org/article/d75a8b56c4c3407cae6253f1d4c6c467 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892007000500002 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/d75a8b56c4c3407cae6253f1d4c6c467 Revista Panamericana de Salud Pública, Vol 21, Iss 6, Pp 345-356 (2007) Costos y análisis de costo hepatitis A esquema de inmunización años de vida ajustados por calidad de vida vacunación Argentina Costs and cost analysis immunization schedule quality-adjusted life years vaccination Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2007 ftdoajarticles 2022-12-31T02:32:38Z OBJECTIVES: To investigate the cost-effectiveness of childhood vaccination against hepatitis A in the five geographic regions of Argentina, and to determine whether adding a second dose to the current one-dose schedule would provide health gains justifying its added cost. METHODS: A Markov model was used to consider four immunization options for the 2005 birth cohort: (1) no vaccination; (2) vaccination at 12 months of age, (3) vaccinations at 12 and 72 months of age; or (4) vaccinations at 12 and 18 months of age. Hepatitis A costs and consequences were predicted over 50 years. The cost-effectiveness of first and second vaccine doses was assessed through a range of vaccine prices and assumptions regarding the duration of vaccine protection. Costs and health gains (measured in quality-adjusted life years) were adjusted to present values using a 3% annual discount rate. RESULTS: The one-dose vaccination policy is predicted to reduce each birth cohort member's 50-year probability of overt hepatitis A from 7.2% to 4.1%. A second dose would reduce the probability to between 2.0% and 2.2%. Vaccination at 12 months of age, at 12 and 72 months, or at 12 and 18 months would reduce cases among personal contacts by 82%, 87%, and 92%, respectively. The first vaccine dose would meet accepted standards of cost-effectiveness in each region, and reduce costs in the Northeast, Central, and South regions. Adding a second dose at age 18 months would be cost-effective in each region, and further reduce costs in the Cuyo region. If the duration of protection with one dose is less than anticipated, the second dose would be more cost-effective. CONCLUSIONS: Greater health gains are derived from the first than second hepatitis A vaccine dose. However, this analysis supports the cost-effectiveness of providing both first and second doses to Argentina's children. OBJETIVOS: Investigar la efectividad en función del costo de la vacunación infantil contra la hepatitis A en las cinco regiones de Argentina y determinar si la adición de una ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Argentina |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Costos y análisis de costo hepatitis A esquema de inmunización años de vida ajustados por calidad de vida vacunación Argentina Costs and cost analysis immunization schedule quality-adjusted life years vaccination Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Costos y análisis de costo hepatitis A esquema de inmunización años de vida ajustados por calidad de vida vacunación Argentina Costs and cost analysis immunization schedule quality-adjusted life years vaccination Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Alejandro Ellis Ricardo W. Rüttimann R. Jake Jacobs Allen S. Meyerhoff Bruce L. Innis Cost-effectiveness of childhood hepatitis A vaccination in Argentina: a second dose is warranted Efectividad en función del costo de la vacunación infantil contra la hepatitis A en Argentina: se justifica una segunda dosis |
topic_facet |
Costos y análisis de costo hepatitis A esquema de inmunización años de vida ajustados por calidad de vida vacunación Argentina Costs and cost analysis immunization schedule quality-adjusted life years vaccination Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVES: To investigate the cost-effectiveness of childhood vaccination against hepatitis A in the five geographic regions of Argentina, and to determine whether adding a second dose to the current one-dose schedule would provide health gains justifying its added cost. METHODS: A Markov model was used to consider four immunization options for the 2005 birth cohort: (1) no vaccination; (2) vaccination at 12 months of age, (3) vaccinations at 12 and 72 months of age; or (4) vaccinations at 12 and 18 months of age. Hepatitis A costs and consequences were predicted over 50 years. The cost-effectiveness of first and second vaccine doses was assessed through a range of vaccine prices and assumptions regarding the duration of vaccine protection. Costs and health gains (measured in quality-adjusted life years) were adjusted to present values using a 3% annual discount rate. RESULTS: The one-dose vaccination policy is predicted to reduce each birth cohort member's 50-year probability of overt hepatitis A from 7.2% to 4.1%. A second dose would reduce the probability to between 2.0% and 2.2%. Vaccination at 12 months of age, at 12 and 72 months, or at 12 and 18 months would reduce cases among personal contacts by 82%, 87%, and 92%, respectively. The first vaccine dose would meet accepted standards of cost-effectiveness in each region, and reduce costs in the Northeast, Central, and South regions. Adding a second dose at age 18 months would be cost-effective in each region, and further reduce costs in the Cuyo region. If the duration of protection with one dose is less than anticipated, the second dose would be more cost-effective. CONCLUSIONS: Greater health gains are derived from the first than second hepatitis A vaccine dose. However, this analysis supports the cost-effectiveness of providing both first and second doses to Argentina's children. OBJETIVOS: Investigar la efectividad en función del costo de la vacunación infantil contra la hepatitis A en las cinco regiones de Argentina y determinar si la adición de una ... |
format |
Article in Journal/Newspaper |
author |
Alejandro Ellis Ricardo W. Rüttimann R. Jake Jacobs Allen S. Meyerhoff Bruce L. Innis |
author_facet |
Alejandro Ellis Ricardo W. Rüttimann R. Jake Jacobs Allen S. Meyerhoff Bruce L. Innis |
author_sort |
Alejandro Ellis |
title |
Cost-effectiveness of childhood hepatitis A vaccination in Argentina: a second dose is warranted Efectividad en función del costo de la vacunación infantil contra la hepatitis A en Argentina: se justifica una segunda dosis |
title_short |
Cost-effectiveness of childhood hepatitis A vaccination in Argentina: a second dose is warranted Efectividad en función del costo de la vacunación infantil contra la hepatitis A en Argentina: se justifica una segunda dosis |
title_full |
Cost-effectiveness of childhood hepatitis A vaccination in Argentina: a second dose is warranted Efectividad en función del costo de la vacunación infantil contra la hepatitis A en Argentina: se justifica una segunda dosis |
title_fullStr |
Cost-effectiveness of childhood hepatitis A vaccination in Argentina: a second dose is warranted Efectividad en función del costo de la vacunación infantil contra la hepatitis A en Argentina: se justifica una segunda dosis |
title_full_unstemmed |
Cost-effectiveness of childhood hepatitis A vaccination in Argentina: a second dose is warranted Efectividad en función del costo de la vacunación infantil contra la hepatitis A en Argentina: se justifica una segunda dosis |
title_sort |
cost-effectiveness of childhood hepatitis a vaccination in argentina: a second dose is warranted efectividad en función del costo de la vacunación infantil contra la hepatitis a en argentina: se justifica una segunda dosis |
publisher |
Pan American Health Organization |
publishDate |
2007 |
url |
https://doaj.org/article/d75a8b56c4c3407cae6253f1d4c6c467 |
geographic |
Arctic Argentina |
geographic_facet |
Arctic Argentina |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 21, Iss 6, Pp 345-356 (2007) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892007000500002 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/d75a8b56c4c3407cae6253f1d4c6c467 |
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1766349647401451520 |