Evaluation of the effects of photooxidized Echis carinatus venom on learning, memory and stress
Snake venoms are a mixture of complex proteins, which have many physical and pharmacological properties. Photochemical detoxification has been suggested to generate photooxidized Echis carinatus venom product (POECVP). Antigenically-active photooxidized species of Echis carinatus venom could be obta...
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ftdoajarticles:oai:doaj.org/article:d75698f83e7b4df49d747b3ece618b5d 2023-05-15T15:09:37+02:00 Evaluation of the effects of photooxidized Echis carinatus venom on learning, memory and stress C. M. Reddy S. P. Gawade 2006-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992006000400010 https://doaj.org/article/d75698f83e7b4df49d747b3ece618b5d EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000400010 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000400010 1678-9199 https://doaj.org/article/d75698f83e7b4df49d747b3ece618b5d Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 4, Pp 632-652 (2006) learning and memory photooxidized Echis carinatus venom product T-maze forced swim test elevated plus-maze Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2006 ftdoajarticles https://doi.org/10.1590/S1678-91992006000400010 2022-12-31T08:49:30Z Snake venoms are a mixture of complex proteins, which have many physical and pharmacological properties. Photochemical detoxification has been suggested to generate photooxidized Echis carinatus venom product (POECVP). Antigenically-active photooxidized species of Echis carinatus venom could be obtained by exposing the venom to ultraviolet radiation (UVR) in the presence of methylene blue. The aim of the present study was to evaluate the effects of POECVP on learning, memory and stress in rats. Detoxification of the photooxidized venom was evident since the POECVP-treated group had longer survival time than the group of mice treated with Echis carinatus venom product (ECVP) following intraperitoneal and intracerebral injections. Photooxidized Echis carinatus venom product showed antidepressant activity by prolonging sleep onset and shortening the duration of pentobarbitone-induced hypnosis in mice. In single and chronic dose studies with rats, we observed that POECVP significantly decreased the time needed to reach food in T-maze, shortened transfer latency in elevated plus-maze, and decreased immobility time in forced swim test. We concluded that although there is a possibility of employing POECVP in the treatment of depressive and chronic degenerative illnesses as a nonherbal and nonsynthetic alternative for patients not responding to the available therapy, further investigation is still needed. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 12 4 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
learning and memory photooxidized Echis carinatus venom product T-maze forced swim test elevated plus-maze Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
learning and memory photooxidized Echis carinatus venom product T-maze forced swim test elevated plus-maze Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 C. M. Reddy S. P. Gawade Evaluation of the effects of photooxidized Echis carinatus venom on learning, memory and stress |
topic_facet |
learning and memory photooxidized Echis carinatus venom product T-maze forced swim test elevated plus-maze Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Snake venoms are a mixture of complex proteins, which have many physical and pharmacological properties. Photochemical detoxification has been suggested to generate photooxidized Echis carinatus venom product (POECVP). Antigenically-active photooxidized species of Echis carinatus venom could be obtained by exposing the venom to ultraviolet radiation (UVR) in the presence of methylene blue. The aim of the present study was to evaluate the effects of POECVP on learning, memory and stress in rats. Detoxification of the photooxidized venom was evident since the POECVP-treated group had longer survival time than the group of mice treated with Echis carinatus venom product (ECVP) following intraperitoneal and intracerebral injections. Photooxidized Echis carinatus venom product showed antidepressant activity by prolonging sleep onset and shortening the duration of pentobarbitone-induced hypnosis in mice. In single and chronic dose studies with rats, we observed that POECVP significantly decreased the time needed to reach food in T-maze, shortened transfer latency in elevated plus-maze, and decreased immobility time in forced swim test. We concluded that although there is a possibility of employing POECVP in the treatment of depressive and chronic degenerative illnesses as a nonherbal and nonsynthetic alternative for patients not responding to the available therapy, further investigation is still needed. |
format |
Article in Journal/Newspaper |
author |
C. M. Reddy S. P. Gawade |
author_facet |
C. M. Reddy S. P. Gawade |
author_sort |
C. M. Reddy |
title |
Evaluation of the effects of photooxidized Echis carinatus venom on learning, memory and stress |
title_short |
Evaluation of the effects of photooxidized Echis carinatus venom on learning, memory and stress |
title_full |
Evaluation of the effects of photooxidized Echis carinatus venom on learning, memory and stress |
title_fullStr |
Evaluation of the effects of photooxidized Echis carinatus venom on learning, memory and stress |
title_full_unstemmed |
Evaluation of the effects of photooxidized Echis carinatus venom on learning, memory and stress |
title_sort |
evaluation of the effects of photooxidized echis carinatus venom on learning, memory and stress |
publisher |
SciELO |
publishDate |
2006 |
url |
https://doi.org/10.1590/S1678-91992006000400010 https://doaj.org/article/d75698f83e7b4df49d747b3ece618b5d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 4, Pp 632-652 (2006) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000400010 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000400010 1678-9199 https://doaj.org/article/d75698f83e7b4df49d747b3ece618b5d |
op_doi |
https://doi.org/10.1590/S1678-91992006000400010 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
12 |
container_issue |
4 |
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