Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants
Abstract Background Malaria is more common in pregnant than in non-pregnant Nigerian women, and is associated with small birth size and the attendant short- and long-term health risks. The influence of malaria on maternal metabolic status in pregnancy and in cord blood and how this relates to birth...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2012
|
Subjects: | |
Online Access: | https://doi.org/10.1186/1475-2875-11-75 https://doaj.org/article/d5c4c20fcd8d4a4c8bc14d0bf68db45e |
id |
ftdoajarticles:oai:doaj.org/article:d5c4c20fcd8d4a4c8bc14d0bf68db45e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:d5c4c20fcd8d4a4c8bc14d0bf68db45e 2023-05-15T15:11:48+02:00 Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants Ayoola Omolola O Whatmore Andrew Balogun Williams O Jarrett Olatokunbo O Cruickshank John K Clayton Peter E 2012-03-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-75 https://doaj.org/article/d5c4c20fcd8d4a4c8bc14d0bf68db45e EN eng BMC http://www.malariajournal.com/content/11/1/75 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-75 1475-2875 https://doaj.org/article/d5c4c20fcd8d4a4c8bc14d0bf68db45e Malaria Journal, Vol 11, Iss 1, p 75 (2012) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-75 2022-12-31T04:57:22Z Abstract Background Malaria is more common in pregnant than in non-pregnant Nigerian women, and is associated with small birth size and the attendant short- and long-term health risks. The influence of malaria on maternal metabolic status in pregnancy and in cord blood and how this relates to birth size has not been studied. The study objective was to define relationships between maternal and cord serum metabolic markers, maternal malaria status and birth size. Methods During pregnancy, anthropometric measurements, blood film for malaria parasites and assays for lipids, glucose, insulin and TNF were obtained from 467 mothers and these analytes and insulin-like growth factor-I (IGF-I) were obtained from cord blood of 187 babies. Results Overall prevalence of maternal malaria was 52%, associated with younger age, anaemia and smaller infant birth size. Mothers with malaria had significantly lower cholesterol (total, HDL and LDL) and higher TNF, but no difference in triglyceride. In contrast, there was no effect of maternal malaria on cord blood lipids, but the median (range) cord IGF-I was significantly lower in babies whose mothers had malaria: 60.4 (24,145)μg/L, versus no malaria: 76.5 (24, 150)μg/L, p = 0.03. On regression analysis, the key determinants of birth weight included maternal total cholesterol, malarial status and cord insulin and IGF-I. Conclusions Malaria in pregnancy was common and associated with reduced birth size, lower maternal lipids and higher TNF. In the setting of endemic malaria, maternal total cholesterol during pregnancy and cord blood insulin and IGF-I levels are potential biomarkers of foetal growth and birth size. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ayoola Omolola O Whatmore Andrew Balogun Williams O Jarrett Olatokunbo O Cruickshank John K Clayton Peter E Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria is more common in pregnant than in non-pregnant Nigerian women, and is associated with small birth size and the attendant short- and long-term health risks. The influence of malaria on maternal metabolic status in pregnancy and in cord blood and how this relates to birth size has not been studied. The study objective was to define relationships between maternal and cord serum metabolic markers, maternal malaria status and birth size. Methods During pregnancy, anthropometric measurements, blood film for malaria parasites and assays for lipids, glucose, insulin and TNF were obtained from 467 mothers and these analytes and insulin-like growth factor-I (IGF-I) were obtained from cord blood of 187 babies. Results Overall prevalence of maternal malaria was 52%, associated with younger age, anaemia and smaller infant birth size. Mothers with malaria had significantly lower cholesterol (total, HDL and LDL) and higher TNF, but no difference in triglyceride. In contrast, there was no effect of maternal malaria on cord blood lipids, but the median (range) cord IGF-I was significantly lower in babies whose mothers had malaria: 60.4 (24,145)μg/L, versus no malaria: 76.5 (24, 150)μg/L, p = 0.03. On regression analysis, the key determinants of birth weight included maternal total cholesterol, malarial status and cord insulin and IGF-I. Conclusions Malaria in pregnancy was common and associated with reduced birth size, lower maternal lipids and higher TNF. In the setting of endemic malaria, maternal total cholesterol during pregnancy and cord blood insulin and IGF-I levels are potential biomarkers of foetal growth and birth size. |
format |
Article in Journal/Newspaper |
author |
Ayoola Omolola O Whatmore Andrew Balogun Williams O Jarrett Olatokunbo O Cruickshank John K Clayton Peter E |
author_facet |
Ayoola Omolola O Whatmore Andrew Balogun Williams O Jarrett Olatokunbo O Cruickshank John K Clayton Peter E |
author_sort |
Ayoola Omolola O |
title |
Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants |
title_short |
Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants |
title_full |
Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants |
title_fullStr |
Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants |
title_full_unstemmed |
Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants |
title_sort |
maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in nigerian infants |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-75 https://doaj.org/article/d5c4c20fcd8d4a4c8bc14d0bf68db45e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 75 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/75 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-75 1475-2875 https://doaj.org/article/d5c4c20fcd8d4a4c8bc14d0bf68db45e |
op_doi |
https://doi.org/10.1186/1475-2875-11-75 |
container_title |
Malaria Journal |
container_volume |
11 |
container_issue |
1 |
_version_ |
1766342596314005504 |