Current Understanding of Immunity Against Schistosomiasis: Impact on Vaccine and Drug Development
Adebayo J Molehin1,2 1Department of Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; 2Center for Tropical Medicine and Infectious Diseases, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USACorresponden...
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ftdoajarticles:oai:doaj.org/article:d586fa25c6874d2a9b122759c1cd3ac4 2023-05-15T15:09:36+02:00 Current Understanding of Immunity Against Schistosomiasis: Impact on Vaccine and Drug Development Molehin AJ 2020-11-01T00:00:00Z https://doaj.org/article/d586fa25c6874d2a9b122759c1cd3ac4 EN eng Dove Medical Press https://www.dovepress.com/current-understanding-of-immunity-against-schistosomiasis-impact-on-va-peer-reviewed-article-RRTM https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/d586fa25c6874d2a9b122759c1cd3ac4 Research and Reports in Tropical Medicine, Vol Volume 11, Pp 119-128 (2020) schistosomiasis immunity schistosomiasis vaccine development resistance to reinfection Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles 2022-12-31T02:41:41Z Adebayo J Molehin1,2 1Department of Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; 2Center for Tropical Medicine and Infectious Diseases, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USACorrespondence: Adebayo J MolehinDepartment of Internal Medicine, School of Medicine,Texas Tech University Health Sciences Center, Lubbock, TX 79430, USATel +1 (806) 743 2639Email adebayo.molehin@ttuhsc.eduAbstract: Schistosomiasis is a neglected tropical disease inflicting significant morbidity in humans worldwide. The disease is caused by infections with a parasitic trematode belonging to the genus Schistosoma. Over 250 million people are currently infected globally, with an estimated disability-adjusted life-years of 1.9 million attributed to the disease. Current understanding, based on several immunological studies using experimental and human models of schistosomiasis, reveals that complex immune mechanisms play off each other in the acquisition of immune resistance to infection/reinfection. Nevertheless, the precise characteristics of these responses, the specific antigens against which they are elicited, and how these responses are intricately regulated are still being investigated. What is apparent is that immunity to schistosome infections develops slowly and over a prolonged period of time, augmented by the death of adult worms occurring naturally or by praziquantel therapy. In this review, aspects of immunity to schistosomiasis, host–parasite interactions and their impact on schistosomiasis vaccine development are discussed.Keywords: schistosomiasis, immunity, schistosomiasis vaccine development, resistance to reinfection Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Lubbock ENVELOPE(169.133,169.133,-73.217,-73.217) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
schistosomiasis immunity schistosomiasis vaccine development resistance to reinfection Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
schistosomiasis immunity schistosomiasis vaccine development resistance to reinfection Arctic medicine. Tropical medicine RC955-962 Molehin AJ Current Understanding of Immunity Against Schistosomiasis: Impact on Vaccine and Drug Development |
topic_facet |
schistosomiasis immunity schistosomiasis vaccine development resistance to reinfection Arctic medicine. Tropical medicine RC955-962 |
description |
Adebayo J Molehin1,2 1Department of Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; 2Center for Tropical Medicine and Infectious Diseases, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USACorrespondence: Adebayo J MolehinDepartment of Internal Medicine, School of Medicine,Texas Tech University Health Sciences Center, Lubbock, TX 79430, USATel +1 (806) 743 2639Email adebayo.molehin@ttuhsc.eduAbstract: Schistosomiasis is a neglected tropical disease inflicting significant morbidity in humans worldwide. The disease is caused by infections with a parasitic trematode belonging to the genus Schistosoma. Over 250 million people are currently infected globally, with an estimated disability-adjusted life-years of 1.9 million attributed to the disease. Current understanding, based on several immunological studies using experimental and human models of schistosomiasis, reveals that complex immune mechanisms play off each other in the acquisition of immune resistance to infection/reinfection. Nevertheless, the precise characteristics of these responses, the specific antigens against which they are elicited, and how these responses are intricately regulated are still being investigated. What is apparent is that immunity to schistosome infections develops slowly and over a prolonged period of time, augmented by the death of adult worms occurring naturally or by praziquantel therapy. In this review, aspects of immunity to schistosomiasis, host–parasite interactions and their impact on schistosomiasis vaccine development are discussed.Keywords: schistosomiasis, immunity, schistosomiasis vaccine development, resistance to reinfection |
format |
Article in Journal/Newspaper |
author |
Molehin AJ |
author_facet |
Molehin AJ |
author_sort |
Molehin AJ |
title |
Current Understanding of Immunity Against Schistosomiasis: Impact on Vaccine and Drug Development |
title_short |
Current Understanding of Immunity Against Schistosomiasis: Impact on Vaccine and Drug Development |
title_full |
Current Understanding of Immunity Against Schistosomiasis: Impact on Vaccine and Drug Development |
title_fullStr |
Current Understanding of Immunity Against Schistosomiasis: Impact on Vaccine and Drug Development |
title_full_unstemmed |
Current Understanding of Immunity Against Schistosomiasis: Impact on Vaccine and Drug Development |
title_sort |
current understanding of immunity against schistosomiasis: impact on vaccine and drug development |
publisher |
Dove Medical Press |
publishDate |
2020 |
url |
https://doaj.org/article/d586fa25c6874d2a9b122759c1cd3ac4 |
long_lat |
ENVELOPE(169.133,169.133,-73.217,-73.217) |
geographic |
Arctic Lubbock |
geographic_facet |
Arctic Lubbock |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Research and Reports in Tropical Medicine, Vol Volume 11, Pp 119-128 (2020) |
op_relation |
https://www.dovepress.com/current-understanding-of-immunity-against-schistosomiasis-impact-on-va-peer-reviewed-article-RRTM https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/d586fa25c6874d2a9b122759c1cd3ac4 |
_version_ |
1766340768159498240 |