Vitamin A supplementation boosts control of antibiotic-resistant Salmonella infection in malnourished mice.
Disseminated disease from non-typhoidal Salmonella enterica strains results in >20% mortality globally. Barriers to effective treatment include emerging multidrug resistance, antibiotic treatment failure, and risk factors such as malnutrition and related micronutrient deficiencies. Individuals in...
Published in: | PLOS Neglected Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:d556704ddc374bbcaf422f82c8b12bed 2023-05-15T15:12:49+02:00 Vitamin A supplementation boosts control of antibiotic-resistant Salmonella infection in malnourished mice. Annica R Stull-Lane Kristen L Lokken-Toyli Vladimir E Diaz-Ochoa Gregory T Walker Stephanie A Cevallos Andromeda L N Winter Ariel Del Hoyo Muñoz Guiyan G Yang Eric M Velazquez Chun-Yi Wu Renée M Tsolis 2020-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008737 https://doaj.org/article/d556704ddc374bbcaf422f82c8b12bed EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008737 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008737 https://doaj.org/article/d556704ddc374bbcaf422f82c8b12bed PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008737 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008737 2022-12-31T07:51:24Z Disseminated disease from non-typhoidal Salmonella enterica strains results in >20% mortality globally. Barriers to effective treatment include emerging multidrug resistance, antibiotic treatment failure, and risk factors such as malnutrition and related micronutrient deficiencies. Individuals in sub-Saharan Africa are disproportionately affected by non-typhoidal S. enterica bloodstream infections. To inform a clinical trial in people, we investigated vitamin A as a treatment in the context of antibiotic treatment failure in a mouse model of vitamin A deficiency. Vitamin A-deficient (VAD) mice exhibited higher systemic bacterial levels with a multidrug-resistant clinical isolate in comparison to mice on a control diet. Sex-specific differences in vitamin A deficiency and disseminated infection with S. enterica serotype Typhimurium (S. Typhimurium) were observed. VAD male mice had decreased weight gain compared to control male mice. Further, infected VAD male mice had significant weight loss and decreased survival during the course of infection. These differences were not apparent in female mice. In a model of disseminated S. Typhimurium infection and antibiotic treatment failure, we assessed the potential of two consecutive doses of vitamin A in alleviating infection in male and female mice on a VAD or control diet. We found that subtherapeutic antibiotic treatment synergized with vitamin A treatment in infected VAD male mice, significantly decreasing systemic bacterial levels, mitigating weight loss and improving survival. These results suggest that assessing vitamin A as a therapy during bacteremia in malnourished patients may lead to improved health outcomes in a subset of patients, especially in the context of antibiotic treatment failure. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 10 e0008737 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Annica R Stull-Lane Kristen L Lokken-Toyli Vladimir E Diaz-Ochoa Gregory T Walker Stephanie A Cevallos Andromeda L N Winter Ariel Del Hoyo Muñoz Guiyan G Yang Eric M Velazquez Chun-Yi Wu Renée M Tsolis Vitamin A supplementation boosts control of antibiotic-resistant Salmonella infection in malnourished mice. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Disseminated disease from non-typhoidal Salmonella enterica strains results in >20% mortality globally. Barriers to effective treatment include emerging multidrug resistance, antibiotic treatment failure, and risk factors such as malnutrition and related micronutrient deficiencies. Individuals in sub-Saharan Africa are disproportionately affected by non-typhoidal S. enterica bloodstream infections. To inform a clinical trial in people, we investigated vitamin A as a treatment in the context of antibiotic treatment failure in a mouse model of vitamin A deficiency. Vitamin A-deficient (VAD) mice exhibited higher systemic bacterial levels with a multidrug-resistant clinical isolate in comparison to mice on a control diet. Sex-specific differences in vitamin A deficiency and disseminated infection with S. enterica serotype Typhimurium (S. Typhimurium) were observed. VAD male mice had decreased weight gain compared to control male mice. Further, infected VAD male mice had significant weight loss and decreased survival during the course of infection. These differences were not apparent in female mice. In a model of disseminated S. Typhimurium infection and antibiotic treatment failure, we assessed the potential of two consecutive doses of vitamin A in alleviating infection in male and female mice on a VAD or control diet. We found that subtherapeutic antibiotic treatment synergized with vitamin A treatment in infected VAD male mice, significantly decreasing systemic bacterial levels, mitigating weight loss and improving survival. These results suggest that assessing vitamin A as a therapy during bacteremia in malnourished patients may lead to improved health outcomes in a subset of patients, especially in the context of antibiotic treatment failure. |
format |
Article in Journal/Newspaper |
author |
Annica R Stull-Lane Kristen L Lokken-Toyli Vladimir E Diaz-Ochoa Gregory T Walker Stephanie A Cevallos Andromeda L N Winter Ariel Del Hoyo Muñoz Guiyan G Yang Eric M Velazquez Chun-Yi Wu Renée M Tsolis |
author_facet |
Annica R Stull-Lane Kristen L Lokken-Toyli Vladimir E Diaz-Ochoa Gregory T Walker Stephanie A Cevallos Andromeda L N Winter Ariel Del Hoyo Muñoz Guiyan G Yang Eric M Velazquez Chun-Yi Wu Renée M Tsolis |
author_sort |
Annica R Stull-Lane |
title |
Vitamin A supplementation boosts control of antibiotic-resistant Salmonella infection in malnourished mice. |
title_short |
Vitamin A supplementation boosts control of antibiotic-resistant Salmonella infection in malnourished mice. |
title_full |
Vitamin A supplementation boosts control of antibiotic-resistant Salmonella infection in malnourished mice. |
title_fullStr |
Vitamin A supplementation boosts control of antibiotic-resistant Salmonella infection in malnourished mice. |
title_full_unstemmed |
Vitamin A supplementation boosts control of antibiotic-resistant Salmonella infection in malnourished mice. |
title_sort |
vitamin a supplementation boosts control of antibiotic-resistant salmonella infection in malnourished mice. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008737 https://doaj.org/article/d556704ddc374bbcaf422f82c8b12bed |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008737 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008737 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008737 https://doaj.org/article/d556704ddc374bbcaf422f82c8b12bed |
op_doi |
https://doi.org/10.1371/journal.pntd.0008737 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
10 |
container_start_page |
e0008737 |
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