Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements

Antibiotic resistance genes (ARGs) are undergoing a remarkably rapid geographic expansion in various ecosystems, including pristine environments such as Antarctica. The study of ARGs and environmental resistance genes (ERGs) mechanisms could provide a better understanding of their origin, evolution,...

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Published in:Microorganisms
Main Authors: Andrés Santos, Felipe Burgos, Jaime Martinez-Urtaza, Leticia Barrientos
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2022
Subjects:
Online Access:https://doi.org/10.3390/microorganisms10071432
https://doaj.org/article/d549c2f0fb2c4767b7c7e4b68c163f97
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spelling ftdoajarticles:oai:doaj.org/article:d549c2f0fb2c4767b7c7e4b68c163f97 2023-05-15T13:44:41+02:00 Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements Andrés Santos Felipe Burgos Jaime Martinez-Urtaza Leticia Barrientos 2022-07-01T00:00:00Z https://doi.org/10.3390/microorganisms10071432 https://doaj.org/article/d549c2f0fb2c4767b7c7e4b68c163f97 EN eng MDPI AG https://www.mdpi.com/2076-2607/10/7/1432 https://doaj.org/toc/2076-2607 doi:10.3390/microorganisms10071432 2076-2607 https://doaj.org/article/d549c2f0fb2c4767b7c7e4b68c163f97 Microorganisms, Vol 10, Iss 1432, p 1432 (2022) Antarctic soils phages plasmids pristine environments Biology (General) QH301-705.5 article 2022 ftdoajarticles https://doi.org/10.3390/microorganisms10071432 2022-12-31T01:04:07Z Antibiotic resistance genes (ARGs) are undergoing a remarkably rapid geographic expansion in various ecosystems, including pristine environments such as Antarctica. The study of ARGs and environmental resistance genes (ERGs) mechanisms could provide a better understanding of their origin, evolution, and dissemination in these pristine environments. Here, we describe the diversity of ARGs and ERGs and the importance of mobile genetic elements as a possible mechanism for the dissemination of resistance genes in Antarctica. We analyzed five soil metagenomes from Deception Island in Antarctica. Results showed that detected ARGs are associated with mechanisms such as antibiotic efflux, antibiotic inactivation, and target alteration. On the other hand, resistance to metals, surfactants, and aromatic hydrocarbons were the dominant ERGs. The taxonomy of ARGs showed that Pseudomonas , Psychrobacter , and Staphylococcus could be key taxa for studying antibiotic resistance and environmental resistance to stress in Deception Island. In addition, results showed that ARGs are mainly associated with phage-type mobile elements suggesting a potential role in their dissemination and prevalence. Finally, these results provide valuable information regarding the ARGs and ERGs in Deception Island including the potential contribution of mobile genetic elements to the spread of ARGs and ERGs in one of the least studied Antarctic ecosystems to date. Article in Journal/Newspaper Antarc* Antarctic Antarctica Deception Island Directory of Open Access Journals: DOAJ Articles Antarctic Deception Island ENVELOPE(-60.633,-60.633,-62.950,-62.950) Microorganisms 10 7 1432
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic Antarctic soils
phages
plasmids
pristine environments
Biology (General)
QH301-705.5
spellingShingle Antarctic soils
phages
plasmids
pristine environments
Biology (General)
QH301-705.5
Andrés Santos
Felipe Burgos
Jaime Martinez-Urtaza
Leticia Barrientos
Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements
topic_facet Antarctic soils
phages
plasmids
pristine environments
Biology (General)
QH301-705.5
description Antibiotic resistance genes (ARGs) are undergoing a remarkably rapid geographic expansion in various ecosystems, including pristine environments such as Antarctica. The study of ARGs and environmental resistance genes (ERGs) mechanisms could provide a better understanding of their origin, evolution, and dissemination in these pristine environments. Here, we describe the diversity of ARGs and ERGs and the importance of mobile genetic elements as a possible mechanism for the dissemination of resistance genes in Antarctica. We analyzed five soil metagenomes from Deception Island in Antarctica. Results showed that detected ARGs are associated with mechanisms such as antibiotic efflux, antibiotic inactivation, and target alteration. On the other hand, resistance to metals, surfactants, and aromatic hydrocarbons were the dominant ERGs. The taxonomy of ARGs showed that Pseudomonas , Psychrobacter , and Staphylococcus could be key taxa for studying antibiotic resistance and environmental resistance to stress in Deception Island. In addition, results showed that ARGs are mainly associated with phage-type mobile elements suggesting a potential role in their dissemination and prevalence. Finally, these results provide valuable information regarding the ARGs and ERGs in Deception Island including the potential contribution of mobile genetic elements to the spread of ARGs and ERGs in one of the least studied Antarctic ecosystems to date.
format Article in Journal/Newspaper
author Andrés Santos
Felipe Burgos
Jaime Martinez-Urtaza
Leticia Barrientos
author_facet Andrés Santos
Felipe Burgos
Jaime Martinez-Urtaza
Leticia Barrientos
author_sort Andrés Santos
title Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements
title_short Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements
title_full Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements
title_fullStr Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements
title_full_unstemmed Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements
title_sort metagenomic characterization of resistance genes in deception island and their association with mobile genetic elements
publisher MDPI AG
publishDate 2022
url https://doi.org/10.3390/microorganisms10071432
https://doaj.org/article/d549c2f0fb2c4767b7c7e4b68c163f97
long_lat ENVELOPE(-60.633,-60.633,-62.950,-62.950)
geographic Antarctic
Deception Island
geographic_facet Antarctic
Deception Island
genre Antarc*
Antarctic
Antarctica
Deception Island
genre_facet Antarc*
Antarctic
Antarctica
Deception Island
op_source Microorganisms, Vol 10, Iss 1432, p 1432 (2022)
op_relation https://www.mdpi.com/2076-2607/10/7/1432
https://doaj.org/toc/2076-2607
doi:10.3390/microorganisms10071432
2076-2607
https://doaj.org/article/d549c2f0fb2c4767b7c7e4b68c163f97
op_doi https://doi.org/10.3390/microorganisms10071432
container_title Microorganisms
container_volume 10
container_issue 7
container_start_page 1432
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