Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy.
BACKGROUND:We reviewed studies that analyzed cysticercosis (CC), neurocysticercosis (NCC) and epilepsy across Latin America, Asia and Sub-Saharan Africa, to estimate the odds ratio and etiologic fraction of epilepsy due to CC in tropical regions. METHODOLOGY:We conducted a systematic review of the l...
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ftdoajarticles:oai:doaj.org/article:d5475d2d35454aa694f0d20afb04e25d 2023-05-15T15:11:07+02:00 Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. Gabrielle Debacq Luz M Moyano Héctor H Garcia Farid Boumediene Benoit Marin Edgard B Ngoungou Pierre-Marie Preux 2017-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005153 https://doaj.org/article/d5475d2d35454aa694f0d20afb04e25d EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5340353?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005153 https://doaj.org/article/d5475d2d35454aa694f0d20afb04e25d PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005153 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005153 2022-12-31T03:15:22Z BACKGROUND:We reviewed studies that analyzed cysticercosis (CC), neurocysticercosis (NCC) and epilepsy across Latin America, Asia and Sub-Saharan Africa, to estimate the odds ratio and etiologic fraction of epilepsy due to CC in tropical regions. METHODOLOGY:We conducted a systematic review of the literature on cysticercosis and epilepsy in the tropics, collecting data from case-control and cross-sectional studies. Exposure criteria for CC included one or more of the following: serum ELISA or EITB positivity, presence of subcutaneous cysts (both not verified and unverified by histology), histology consistent with calcified cysts, and brain CT scan consistent with NCC. A common odds-ratio was then estimated using meta-analysis. PRINCIPAL FINDINGS:37 studies from 23 countries were included (n = 24,646 subjects, 14,934 with epilepsy and 9,712 without epilepsy). Of these, 29 were case-control (14 matched). The association between CC and epilepsy was significant in 19 scientific articles. Odds ratios ranged from 0.2 to 25.4 (a posteriori power 4.5-100%) and the common odds ratio was 2.7 (95% CI 2.1-3.6, p <0.001). Three subgroup analyses performed gave odds ratios as: 2.2 (EITB-based studies), 3.2 (CT-based studies), 1.9 (neurologist-confirmed epilepsy; door-to-door survey and at least one matched control per case). Etiologic fraction was estimated to be 63% in the exposed group among the population. SIGNIFICANCE:Despite differences in findings, this meta-analysis suggests that cysticercosis is a significant contributor to late-onset epilepsy in tropical regions around the world, and its impact may vary depending on transmission intensity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 3 e0005153 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Gabrielle Debacq Luz M Moyano Héctor H Garcia Farid Boumediene Benoit Marin Edgard B Ngoungou Pierre-Marie Preux Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:We reviewed studies that analyzed cysticercosis (CC), neurocysticercosis (NCC) and epilepsy across Latin America, Asia and Sub-Saharan Africa, to estimate the odds ratio and etiologic fraction of epilepsy due to CC in tropical regions. METHODOLOGY:We conducted a systematic review of the literature on cysticercosis and epilepsy in the tropics, collecting data from case-control and cross-sectional studies. Exposure criteria for CC included one or more of the following: serum ELISA or EITB positivity, presence of subcutaneous cysts (both not verified and unverified by histology), histology consistent with calcified cysts, and brain CT scan consistent with NCC. A common odds-ratio was then estimated using meta-analysis. PRINCIPAL FINDINGS:37 studies from 23 countries were included (n = 24,646 subjects, 14,934 with epilepsy and 9,712 without epilepsy). Of these, 29 were case-control (14 matched). The association between CC and epilepsy was significant in 19 scientific articles. Odds ratios ranged from 0.2 to 25.4 (a posteriori power 4.5-100%) and the common odds ratio was 2.7 (95% CI 2.1-3.6, p <0.001). Three subgroup analyses performed gave odds ratios as: 2.2 (EITB-based studies), 3.2 (CT-based studies), 1.9 (neurologist-confirmed epilepsy; door-to-door survey and at least one matched control per case). Etiologic fraction was estimated to be 63% in the exposed group among the population. SIGNIFICANCE:Despite differences in findings, this meta-analysis suggests that cysticercosis is a significant contributor to late-onset epilepsy in tropical regions around the world, and its impact may vary depending on transmission intensity. |
format |
Article in Journal/Newspaper |
author |
Gabrielle Debacq Luz M Moyano Héctor H Garcia Farid Boumediene Benoit Marin Edgard B Ngoungou Pierre-Marie Preux |
author_facet |
Gabrielle Debacq Luz M Moyano Héctor H Garcia Farid Boumediene Benoit Marin Edgard B Ngoungou Pierre-Marie Preux |
author_sort |
Gabrielle Debacq |
title |
Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. |
title_short |
Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. |
title_full |
Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. |
title_fullStr |
Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. |
title_full_unstemmed |
Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. |
title_sort |
systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005153 https://doaj.org/article/d5475d2d35454aa694f0d20afb04e25d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005153 (2017) |
op_relation |
http://europepmc.org/articles/PMC5340353?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005153 https://doaj.org/article/d5475d2d35454aa694f0d20afb04e25d |
op_doi |
https://doi.org/10.1371/journal.pntd.0005153 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
3 |
container_start_page |
e0005153 |
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1766342028698845184 |