Prevalence of Neurocysticercosis in People with Epilepsy in the Eastern Province of Zambia.
Zambia is endemic for Taenia solium taeniosis and cysticercosis. In this single-centered, cross-sectional, community-based study, the role of neurocysticercosis (NCC) as a cause of epilepsy was examined. People with epilepsy (PWE, n = 56) were identified in an endemic area using a screening question...
Published in: | PLOS Neglected Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:d4f116a878bf4adc9a04e40a46b92f3e 2023-05-15T15:11:52+02:00 Prevalence of Neurocysticercosis in People with Epilepsy in the Eastern Province of Zambia. Kabemba E Mwape Joachim Blocher Jasmin Wiefek Kathie Schmidt Pierre Dorny Nicolas Praet Clarance Chiluba Holger Schmidt Isaac K Phiri Andrea S Winkler Sarah Gabriël 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003972 https://doaj.org/article/d4f116a878bf4adc9a04e40a46b92f3e EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4540454?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003972 https://doaj.org/article/d4f116a878bf4adc9a04e40a46b92f3e PLoS Neglected Tropical Diseases, Vol 9, Iss 8, p e0003972 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003972 2022-12-31T13:04:06Z Zambia is endemic for Taenia solium taeniosis and cysticercosis. In this single-centered, cross-sectional, community-based study, the role of neurocysticercosis (NCC) as a cause of epilepsy was examined. People with epilepsy (PWE, n = 56) were identified in an endemic area using a screening questionnaire followed by in-depth interviews and neurological examination. Computed tomography (CT) was performed on 49 people with active epilepsy (PWAE) and their sera (specific antibody and antigen detection, n = 56) and stools (copro-antigen detection, n = 54) were analyzed. The CT scan findings were compared to a group of 40 CT scan controls. Of the PWE, 39.3% and 23.2% were positive for cysticercal antibodies and antigens, respectively, and 14.8% for coproantigens (taeniosis). Lesions highly suggestive of NCC were detected in 24.5% and definite NCC lesions in 4.1% of CT scans of PWAE. This compares to 2.5% and 0%, respectively, in the control CT scans. Using the Del Brutto diagnostic criteria, 51.8% of the PWAE were diagnosed with probable or definitive NCC and this rose to 57.1% when the adapted criteria, as proposed by Gabriël et al. (adding the sero-antigen ELISA test as a major criterion), were used. There was no statistically significant relationship between NCC, current age, age at first seizure and gender. This study suggests that NCC is the single most important cause of epilepsy in the study area. Additional large-scale studies, combining a community based prevalence study for epilepsy with neuroimaging and serological analysis in different areas are needed to estimate the true impact of neurocysticercosis in endemic regions and efforts should be instituted to the control of T. solium. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Brutto ENVELOPE(20.743,20.743,69.985,69.985) PLOS Neglected Tropical Diseases 9 8 e0003972 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Kabemba E Mwape Joachim Blocher Jasmin Wiefek Kathie Schmidt Pierre Dorny Nicolas Praet Clarance Chiluba Holger Schmidt Isaac K Phiri Andrea S Winkler Sarah Gabriël Prevalence of Neurocysticercosis in People with Epilepsy in the Eastern Province of Zambia. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Zambia is endemic for Taenia solium taeniosis and cysticercosis. In this single-centered, cross-sectional, community-based study, the role of neurocysticercosis (NCC) as a cause of epilepsy was examined. People with epilepsy (PWE, n = 56) were identified in an endemic area using a screening questionnaire followed by in-depth interviews and neurological examination. Computed tomography (CT) was performed on 49 people with active epilepsy (PWAE) and their sera (specific antibody and antigen detection, n = 56) and stools (copro-antigen detection, n = 54) were analyzed. The CT scan findings were compared to a group of 40 CT scan controls. Of the PWE, 39.3% and 23.2% were positive for cysticercal antibodies and antigens, respectively, and 14.8% for coproantigens (taeniosis). Lesions highly suggestive of NCC were detected in 24.5% and definite NCC lesions in 4.1% of CT scans of PWAE. This compares to 2.5% and 0%, respectively, in the control CT scans. Using the Del Brutto diagnostic criteria, 51.8% of the PWAE were diagnosed with probable or definitive NCC and this rose to 57.1% when the adapted criteria, as proposed by Gabriël et al. (adding the sero-antigen ELISA test as a major criterion), were used. There was no statistically significant relationship between NCC, current age, age at first seizure and gender. This study suggests that NCC is the single most important cause of epilepsy in the study area. Additional large-scale studies, combining a community based prevalence study for epilepsy with neuroimaging and serological analysis in different areas are needed to estimate the true impact of neurocysticercosis in endemic regions and efforts should be instituted to the control of T. solium. |
format |
Article in Journal/Newspaper |
author |
Kabemba E Mwape Joachim Blocher Jasmin Wiefek Kathie Schmidt Pierre Dorny Nicolas Praet Clarance Chiluba Holger Schmidt Isaac K Phiri Andrea S Winkler Sarah Gabriël |
author_facet |
Kabemba E Mwape Joachim Blocher Jasmin Wiefek Kathie Schmidt Pierre Dorny Nicolas Praet Clarance Chiluba Holger Schmidt Isaac K Phiri Andrea S Winkler Sarah Gabriël |
author_sort |
Kabemba E Mwape |
title |
Prevalence of Neurocysticercosis in People with Epilepsy in the Eastern Province of Zambia. |
title_short |
Prevalence of Neurocysticercosis in People with Epilepsy in the Eastern Province of Zambia. |
title_full |
Prevalence of Neurocysticercosis in People with Epilepsy in the Eastern Province of Zambia. |
title_fullStr |
Prevalence of Neurocysticercosis in People with Epilepsy in the Eastern Province of Zambia. |
title_full_unstemmed |
Prevalence of Neurocysticercosis in People with Epilepsy in the Eastern Province of Zambia. |
title_sort |
prevalence of neurocysticercosis in people with epilepsy in the eastern province of zambia. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003972 https://doaj.org/article/d4f116a878bf4adc9a04e40a46b92f3e |
long_lat |
ENVELOPE(20.743,20.743,69.985,69.985) |
geographic |
Arctic Brutto |
geographic_facet |
Arctic Brutto |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 8, p e0003972 (2015) |
op_relation |
http://europepmc.org/articles/PMC4540454?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003972 https://doaj.org/article/d4f116a878bf4adc9a04e40a46b92f3e |
op_doi |
https://doi.org/10.1371/journal.pntd.0003972 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
9 |
container_issue |
8 |
container_start_page |
e0003972 |
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1766342653096493056 |