Anti-inflammatory, antipyretic and antioxidant activities of the earthworms extract
Introduction: Earthworms are the major biomass in soil. They have been widely used in traditional Chinese medicine for a long time. However, in the past few decades with the development of biochemical technologies the research on the pharmaceutical effects of earthworms has been commencement.Aims: E...
Main Authors: | , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
TMKarpinski Publisher, Tomasz M. Karpiński
2012
|
Subjects: | |
Online Access: | https://doaj.org/article/d4cd2218a32149d98d0a9109c5afd5c4 |
id |
ftdoajarticles:oai:doaj.org/article:d4cd2218a32149d98d0a9109c5afd5c4 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:d4cd2218a32149d98d0a9109c5afd5c4 2023-05-15T18:05:25+02:00 Anti-inflammatory, antipyretic and antioxidant activities of the earthworms extract Hossam El-Din Mohamed Omar Zedan Z. Ibraheim Nasser A. El-Shimy Rouwaida S. Ali 2012-01-01T00:00:00Z https://doaj.org/article/d4cd2218a32149d98d0a9109c5afd5c4 EN eng TMKarpinski Publisher, Tomasz M. Karpiński http://www.journals.tmkarpinski.com/index.php/jbes/article/view/6/9 https://doaj.org/toc/2084-3577 2084-3577 https://doaj.org/article/d4cd2218a32149d98d0a9109c5afd5c4 Journal of Biology and Earth Sciences, Vol 2, Iss 1, Pp B10-B17 (2012) Earthworms antiinflammatory anti-pyretics histamine indomethacine paracetmol CCL4 Biology (General) QH301-705.5 article 2012 ftdoajarticles 2022-12-31T13:22:31Z Introduction: Earthworms are the major biomass in soil. They have been widely used in traditional Chinese medicine for a long time. However, in the past few decades with the development of biochemical technologies the research on the pharmaceutical effects of earthworms has been commencement.Aims: Experiments were conducted to recognize the therapeutic properties such as anti-inflammatory, antipyretic and antioxidant activities of biologically active extract isolated from two species of earthworm (Pheretima hawayana Rosa and Allolobophora caliginosa Savigny).Materials and methods: inflammation in the hind paw of albino rat, Rattus rattus, was induced by histamine, pyrexia was induced by Escherichia coli in rats and liver damage was induced by injection of rats with CCl4. Anti-inflammatory drug - indomethacin, anti-pyretic drug - paracetamol and antioxidant drug - silymarin plus were used as standard drug for comparison.Results: Administration of Eearthworms extract (100 mg/kg) and indomethacin (10 mg/kg), paracetamol (150 mg/kg), silymarin plus (150 mg/kg) as standard drugs reduced and restored to normal the changes that induced by histamine, Escherichia coli and CCl4 in rats.Conclusions: The present study conclude that both extract of earthworms gave result as anti-inflammatory and anti-pyretic similar to the standard drugs. The extract of the two species showed various responds as antioxidants against CCl4 induced hepatotoxicity. Article in Journal/Newspaper Rattus rattus Directory of Open Access Journals: DOAJ Articles |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Earthworms antiinflammatory anti-pyretics histamine indomethacine paracetmol CCL4 Biology (General) QH301-705.5 |
spellingShingle |
Earthworms antiinflammatory anti-pyretics histamine indomethacine paracetmol CCL4 Biology (General) QH301-705.5 Hossam El-Din Mohamed Omar Zedan Z. Ibraheim Nasser A. El-Shimy Rouwaida S. Ali Anti-inflammatory, antipyretic and antioxidant activities of the earthworms extract |
topic_facet |
Earthworms antiinflammatory anti-pyretics histamine indomethacine paracetmol CCL4 Biology (General) QH301-705.5 |
description |
Introduction: Earthworms are the major biomass in soil. They have been widely used in traditional Chinese medicine for a long time. However, in the past few decades with the development of biochemical technologies the research on the pharmaceutical effects of earthworms has been commencement.Aims: Experiments were conducted to recognize the therapeutic properties such as anti-inflammatory, antipyretic and antioxidant activities of biologically active extract isolated from two species of earthworm (Pheretima hawayana Rosa and Allolobophora caliginosa Savigny).Materials and methods: inflammation in the hind paw of albino rat, Rattus rattus, was induced by histamine, pyrexia was induced by Escherichia coli in rats and liver damage was induced by injection of rats with CCl4. Anti-inflammatory drug - indomethacin, anti-pyretic drug - paracetamol and antioxidant drug - silymarin plus were used as standard drug for comparison.Results: Administration of Eearthworms extract (100 mg/kg) and indomethacin (10 mg/kg), paracetamol (150 mg/kg), silymarin plus (150 mg/kg) as standard drugs reduced and restored to normal the changes that induced by histamine, Escherichia coli and CCl4 in rats.Conclusions: The present study conclude that both extract of earthworms gave result as anti-inflammatory and anti-pyretic similar to the standard drugs. The extract of the two species showed various responds as antioxidants against CCl4 induced hepatotoxicity. |
format |
Article in Journal/Newspaper |
author |
Hossam El-Din Mohamed Omar Zedan Z. Ibraheim Nasser A. El-Shimy Rouwaida S. Ali |
author_facet |
Hossam El-Din Mohamed Omar Zedan Z. Ibraheim Nasser A. El-Shimy Rouwaida S. Ali |
author_sort |
Hossam El-Din Mohamed Omar |
title |
Anti-inflammatory, antipyretic and antioxidant activities of the earthworms extract |
title_short |
Anti-inflammatory, antipyretic and antioxidant activities of the earthworms extract |
title_full |
Anti-inflammatory, antipyretic and antioxidant activities of the earthworms extract |
title_fullStr |
Anti-inflammatory, antipyretic and antioxidant activities of the earthworms extract |
title_full_unstemmed |
Anti-inflammatory, antipyretic and antioxidant activities of the earthworms extract |
title_sort |
anti-inflammatory, antipyretic and antioxidant activities of the earthworms extract |
publisher |
TMKarpinski Publisher, Tomasz M. Karpiński |
publishDate |
2012 |
url |
https://doaj.org/article/d4cd2218a32149d98d0a9109c5afd5c4 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Journal of Biology and Earth Sciences, Vol 2, Iss 1, Pp B10-B17 (2012) |
op_relation |
http://www.journals.tmkarpinski.com/index.php/jbes/article/view/6/9 https://doaj.org/toc/2084-3577 2084-3577 https://doaj.org/article/d4cd2218a32149d98d0a9109c5afd5c4 |
_version_ |
1766176882873597952 |