The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study.
BACKGROUND:The relationship between malaria and undernutrition is controversial and complex. Synergistic associations between malnutrition and malaria morbidity and mortality have been suggested, as well as undernutrition being protective against infection, while other studies found no association....
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ftdoajarticles:oai:doaj.org/article:d4969acf34d24916a9d5e2ff5beac023 2023-05-15T15:14:41+02:00 The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study. Márcia Almeida Araújo Alexandre Silvana Gomes Benzecry Andre Machado Siqueira Sheila Vitor-Silva Gisely Cardoso Melo Wuelton Marcelo Monteiro Heitor Pons Leite Marcus Vinícius Guimarães Lacerda Maria das Graças Costa Alecrim 2015-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003743 https://doaj.org/article/d4969acf34d24916a9d5e2ff5beac023 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4415998?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003743 https://doaj.org/article/d4969acf34d24916a9d5e2ff5beac023 PLoS Neglected Tropical Diseases, Vol 9, Iss 4, p e0003743 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003743 2022-12-30T23:33:24Z BACKGROUND:The relationship between malaria and undernutrition is controversial and complex. Synergistic associations between malnutrition and malaria morbidity and mortality have been suggested, as well as undernutrition being protective against infection, while other studies found no association. We sought to evaluate the relationship between the number of malaria episodes and nutritional statuses in a cohort of children below 15 years of age living in a rural community in the Brazilian Amazon. METHODOLOGY/PRINCIPAL FINDINGS:Following a baseline survey of clinical, malaria and nutritional assessment including anthropometry measurements and hemoglobin concentration, 202 children ranging from 1 month to 14 years of age were followed for one year through passive case detection for malaria episodes. After follow-up, all children were assessed again in order to detect changes in nutritional indicators associated with malaria infection. We also examined the risk of presenting malaria episodes during follow-up according to presence of stunting at baseline. Children who suffered malaria episodes during follow-up presented worse anthropometric parameters values during this period. The main change was a reduction of the linear growth velocity, associated with both the number of episodes and how close the last or only malaria episode and the second anthropometric assessment were. Changes were also observed for indices associated with chronic changes, such as weight-for-age and BMI-for-age, which conversely, were more frequently observed in children with the last or only episode occurring between 6 and 12 months preceding the second nutritional assessment survey. Children with inadequate height-for-age at baseline (Z-score < -2) presented lower risk of suffering malaria episodes during follow-up as assessed by both the log-rank test (p =0.057) and the multivariable Cox-proportional hazards regression (Hazard Ratio = 0.31, 95%CI [0.10; 0.99] p=0.049). CONCLUSIONS:Malaria was associated with impaired nutritional status ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 4 e0003743 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Márcia Almeida Araújo Alexandre Silvana Gomes Benzecry Andre Machado Siqueira Sheila Vitor-Silva Gisely Cardoso Melo Wuelton Marcelo Monteiro Heitor Pons Leite Marcus Vinícius Guimarães Lacerda Maria das Graças Costa Alecrim The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:The relationship between malaria and undernutrition is controversial and complex. Synergistic associations between malnutrition and malaria morbidity and mortality have been suggested, as well as undernutrition being protective against infection, while other studies found no association. We sought to evaluate the relationship between the number of malaria episodes and nutritional statuses in a cohort of children below 15 years of age living in a rural community in the Brazilian Amazon. METHODOLOGY/PRINCIPAL FINDINGS:Following a baseline survey of clinical, malaria and nutritional assessment including anthropometry measurements and hemoglobin concentration, 202 children ranging from 1 month to 14 years of age were followed for one year through passive case detection for malaria episodes. After follow-up, all children were assessed again in order to detect changes in nutritional indicators associated with malaria infection. We also examined the risk of presenting malaria episodes during follow-up according to presence of stunting at baseline. Children who suffered malaria episodes during follow-up presented worse anthropometric parameters values during this period. The main change was a reduction of the linear growth velocity, associated with both the number of episodes and how close the last or only malaria episode and the second anthropometric assessment were. Changes were also observed for indices associated with chronic changes, such as weight-for-age and BMI-for-age, which conversely, were more frequently observed in children with the last or only episode occurring between 6 and 12 months preceding the second nutritional assessment survey. Children with inadequate height-for-age at baseline (Z-score < -2) presented lower risk of suffering malaria episodes during follow-up as assessed by both the log-rank test (p =0.057) and the multivariable Cox-proportional hazards regression (Hazard Ratio = 0.31, 95%CI [0.10; 0.99] p=0.049). CONCLUSIONS:Malaria was associated with impaired nutritional status ... |
format |
Article in Journal/Newspaper |
author |
Márcia Almeida Araújo Alexandre Silvana Gomes Benzecry Andre Machado Siqueira Sheila Vitor-Silva Gisely Cardoso Melo Wuelton Marcelo Monteiro Heitor Pons Leite Marcus Vinícius Guimarães Lacerda Maria das Graças Costa Alecrim |
author_facet |
Márcia Almeida Araújo Alexandre Silvana Gomes Benzecry Andre Machado Siqueira Sheila Vitor-Silva Gisely Cardoso Melo Wuelton Marcelo Monteiro Heitor Pons Leite Marcus Vinícius Guimarães Lacerda Maria das Graças Costa Alecrim |
author_sort |
Márcia Almeida Araújo Alexandre |
title |
The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study. |
title_short |
The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study. |
title_full |
The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study. |
title_fullStr |
The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study. |
title_full_unstemmed |
The association between nutritional status and malaria in children from a rural community in the Amazonian region: a longitudinal study. |
title_sort |
association between nutritional status and malaria in children from a rural community in the amazonian region: a longitudinal study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003743 https://doaj.org/article/d4969acf34d24916a9d5e2ff5beac023 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 4, p e0003743 (2015) |
op_relation |
http://europepmc.org/articles/PMC4415998?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003743 https://doaj.org/article/d4969acf34d24916a9d5e2ff5beac023 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003743 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
9 |
container_issue |
4 |
container_start_page |
e0003743 |
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1766345111137943552 |