Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives
Schistosomiasis is a major public health problem with 207 million people infected and more than 779 million at risk. The drug of choice for treating schistosomiasis is praziquantel (PZQ); however, it is inefficient against immature forms of schistosomes. The aim of this study was to test new imidazo...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:d47146f2220645099d087a6623984741 2023-05-15T15:04:28+02:00 Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives Neves JKAL Sarinho S de Melo CML Pereira VRA de Lima MCA Pitta IR Albuquerque MCPA Galdino SL 2011-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992011000300007 https://doaj.org/article/d47146f2220645099d087a6623984741 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300007 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992011000300007 1678-9199 https://doaj.org/article/d47146f2220645099d087a6623984741 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 3, Pp 277-286 (2011) Schistosoma mansoni in vitro imidazolidines Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2011 ftdoajarticles https://doi.org/10.1590/S1678-91992011000300007 2022-12-31T13:36:30Z Schistosomiasis is a major public health problem with 207 million people infected and more than 779 million at risk. The drug of choice for treating schistosomiasis is praziquantel (PZQ); however, it is inefficient against immature forms of schistosomes. The aim of this study was to test new imidazolidine derivatives LPSF/PT09 and LPSF/PT10 against adult Schistosoma mansoni worms. IC50, cytotoxicity, immune response and cell viability assays were also available for these imidazolidines. Different concentrations of imidazolidine, from 32 to 320 ¼M, promoted motor abnormalities in breeding and unpaired worms, and death in 24 hours at higher concentrations. Although LPSF/PT09 and LPSF/PT10 did not affect IFN-³ and IL-10 production, they induced nitric oxide production and showed a similar behavior to praziquantel on cell death test. Thus, these new imidazolidine derivatives should undergo further study to develop schistosomiasis drugs. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 17 3 277 286 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Schistosoma mansoni in vitro imidazolidines Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Schistosoma mansoni in vitro imidazolidines Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Neves JKAL Sarinho S de Melo CML Pereira VRA de Lima MCA Pitta IR Albuquerque MCPA Galdino SL Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
topic_facet |
Schistosoma mansoni in vitro imidazolidines Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Schistosomiasis is a major public health problem with 207 million people infected and more than 779 million at risk. The drug of choice for treating schistosomiasis is praziquantel (PZQ); however, it is inefficient against immature forms of schistosomes. The aim of this study was to test new imidazolidine derivatives LPSF/PT09 and LPSF/PT10 against adult Schistosoma mansoni worms. IC50, cytotoxicity, immune response and cell viability assays were also available for these imidazolidines. Different concentrations of imidazolidine, from 32 to 320 ¼M, promoted motor abnormalities in breeding and unpaired worms, and death in 24 hours at higher concentrations. Although LPSF/PT09 and LPSF/PT10 did not affect IFN-³ and IL-10 production, they induced nitric oxide production and showed a similar behavior to praziquantel on cell death test. Thus, these new imidazolidine derivatives should undergo further study to develop schistosomiasis drugs. |
format |
Article in Journal/Newspaper |
author |
Neves JKAL Sarinho S de Melo CML Pereira VRA de Lima MCA Pitta IR Albuquerque MCPA Galdino SL |
author_facet |
Neves JKAL Sarinho S de Melo CML Pereira VRA de Lima MCA Pitta IR Albuquerque MCPA Galdino SL |
author_sort |
Neves JKAL |
title |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
title_short |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
title_full |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
title_fullStr |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
title_full_unstemmed |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
title_sort |
immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
publisher |
SciELO |
publishDate |
2011 |
url |
https://doi.org/10.1590/S1678-91992011000300007 https://doaj.org/article/d47146f2220645099d087a6623984741 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 3, Pp 277-286 (2011) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300007 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992011000300007 1678-9199 https://doaj.org/article/d47146f2220645099d087a6623984741 |
op_doi |
https://doi.org/10.1590/S1678-91992011000300007 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
17 |
container_issue |
3 |
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277 |
op_container_end_page |
286 |
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