Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates
Abstract INTRODUCTION The relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated. METHODS Thirty isolates were used to determine the mucoid aspect. Four were selected fo...
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ftdoajarticles:oai:doaj.org/article:d4479f651d4c42758a9695de926311a8 2023-05-15T15:00:21+02:00 Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates Francinete Carla Nunes Cavalcanti Juliana Falcão Rodrigues Adriane Borges Cabral Larissa Caina Barbosa de Azarias Marcos Antônio de Morais Júnior Célia Maria Machado Barbosa de Castro Ana Catarina de Souza Lopes 2019-04-01T00:00:00Z https://doi.org/10.1590/0037-8682-0089-2019 https://doaj.org/article/d4479f651d4c42758a9695de926311a8 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100648&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0089-2019 https://doaj.org/article/d4479f651d4c42758a9695de926311a8 Revista da Sociedade Brasileira de Medicina Tropical, Vol 52, Iss 0 (2019) Klebsiella pneumoniae Alveolar macrophages Phagocytosis Mucoid phenotype Genetic characteristics Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.1590/0037-8682-0089-2019 2022-12-30T23:22:44Z Abstract INTRODUCTION The relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated. METHODS Thirty isolates were used to determine the mucoid aspect. Four were selected for analysis of phagocytosis by alveolar macrophages. RESULTS Thirty percent of the samples presented the mucoid phenotype. The phagocytosis rate ranged from 21.5% to 43.43%. Phagocytosis was not correlated with the plasmid profile, but was apparently correlated with mucoid phenotype and antibiotic susceptibility. CONCLUSIONS: Several virulence factors act in parallel in K. pneumoniae to impair host defense. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 52 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Klebsiella pneumoniae Alveolar macrophages Phagocytosis Mucoid phenotype Genetic characteristics Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Klebsiella pneumoniae Alveolar macrophages Phagocytosis Mucoid phenotype Genetic characteristics Arctic medicine. Tropical medicine RC955-962 Francinete Carla Nunes Cavalcanti Juliana Falcão Rodrigues Adriane Borges Cabral Larissa Caina Barbosa de Azarias Marcos Antônio de Morais Júnior Célia Maria Machado Barbosa de Castro Ana Catarina de Souza Lopes Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates |
topic_facet |
Klebsiella pneumoniae Alveolar macrophages Phagocytosis Mucoid phenotype Genetic characteristics Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION The relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated. METHODS Thirty isolates were used to determine the mucoid aspect. Four were selected for analysis of phagocytosis by alveolar macrophages. RESULTS Thirty percent of the samples presented the mucoid phenotype. The phagocytosis rate ranged from 21.5% to 43.43%. Phagocytosis was not correlated with the plasmid profile, but was apparently correlated with mucoid phenotype and antibiotic susceptibility. CONCLUSIONS: Several virulence factors act in parallel in K. pneumoniae to impair host defense. |
format |
Article in Journal/Newspaper |
author |
Francinete Carla Nunes Cavalcanti Juliana Falcão Rodrigues Adriane Borges Cabral Larissa Caina Barbosa de Azarias Marcos Antônio de Morais Júnior Célia Maria Machado Barbosa de Castro Ana Catarina de Souza Lopes |
author_facet |
Francinete Carla Nunes Cavalcanti Juliana Falcão Rodrigues Adriane Borges Cabral Larissa Caina Barbosa de Azarias Marcos Antônio de Morais Júnior Célia Maria Machado Barbosa de Castro Ana Catarina de Souza Lopes |
author_sort |
Francinete Carla Nunes Cavalcanti |
title |
Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates |
title_short |
Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates |
title_full |
Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates |
title_fullStr |
Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates |
title_full_unstemmed |
Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates |
title_sort |
relationships between phagocytosis, mucoid phenotype, and genetic characteristics of klebsiella pneumoniae clinical isolates |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2019 |
url |
https://doi.org/10.1590/0037-8682-0089-2019 https://doaj.org/article/d4479f651d4c42758a9695de926311a8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 52, Iss 0 (2019) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100648&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0089-2019 https://doaj.org/article/d4479f651d4c42758a9695de926311a8 |
op_doi |
https://doi.org/10.1590/0037-8682-0089-2019 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
52 |
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