Etiological drug treatment of human infection by Trypanosoma cruzi Tratamento etiológico por droga da infecção humana pelo Trypanosoma cruzi
Forty-nine American Trypanosomiasis (Chagas' disease) patients, with xenodiagnosis proven parasitemia were treated by the authors. Forty-one of these patients were given benznidazole, at dosages ranging from 5mg/kg/day to 8mg/kg/day, during a pre-established period of 60 days. In this group, 17...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
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ftdoajarticles:oai:doaj.org/article:d43063417707490693aac59bee335dfb 2024-09-09T19:28:27+00:00 Etiological drug treatment of human infection by Trypanosoma cruzi Tratamento etiológico por droga da infecção humana pelo Trypanosoma cruzi Guido Carlos Levi Isa Maria Fraga Lobo Esper Georges Kallás Vicente Amato Neto 1996-02-01T00:00:00Z https://doi.org/10.1590/S0036-46651996000100007 https://doaj.org/article/d43063417707490693aac59bee335dfb EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651996000100007 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651996000100007 0036-4665 1678-9946 https://doaj.org/article/d43063417707490693aac59bee335dfb Revista do Instituto de Medicina Tropical de São Paulo, Vol 38, Iss 1, Pp 35-38 (1996) Chronic Chagas' disease Antiparasitic treatment Benznidazole Nifurtimox Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1996 ftdoajarticles https://doi.org/10.1590/S0036-46651996000100007 2024-08-05T17:49:30Z Forty-nine American Trypanosomiasis (Chagas' disease) patients, with xenodiagnosis proven parasitemia were treated by the authors. Forty-one of these patients were given benznidazole, at dosages ranging from 5mg/kg/day to 8mg/kg/day, during a pre-established period of 60 days. In this group, 17 patients had an undetermined form of the disease, whereas 22 had cardiologic disease and 4 had digestive disease (two patients had a mixed form of the disease). Side effects were frequent, and led to the discontinuation of treatment in 17 patients. The follow-up period ranged from 1 to 20 years (mean follow-up period of 6 yrs. 7 mo). 26 (63.4%) of the patients became parasitemia-negative. The other eight patients were treated with nifurtimox, during 120 days, following a variable dose regime of 5mg/kg/day (initial dose) to 17 mg/kg/day (final dose). Six of them had severe side effects, and only one patient remained parasitemia-negative throughout the observation period (ranging from 1 to 18 years). Benznidazole proved to be better tolerated and more effective in the management of parasitemia when compared to nifurtimox, although more effective and less toxic drugs are still desirable. Por meio do benznidazol e do nifurtimox foram tratados 49 pacientes acometidos de doença de Chagas. Xenodiagnóstico prévio tinha sempre resultado positivo, evidenciando parasitemia pelo Trypanosoma cruzi e sendo as seguintes as formas clínicas: indeterminada-19; cardíaca-28; digestiva-4 (dois pacientes apresentavam formas mistas). Quanto ao benznidazol, houve administração de 5 a 8 mg/kg/dia, durante dois meses, e a propósito do nifurtimox o esquema terapêutico começou com a dose de 5 a 7 mg/kg/dia, sucedendo aumento progressivo até 15 a 17 mg/kg/dia, no decurso de quatro meses. O benznidazol, usado por 41 doentes, propiciou negativação em 26 (63.4%) à avaliação realizada por meio do xenodiagnóstico, em etapas de um a 20 anos e, em média, de 6 a 7 anos. Por seu turno, com o nifurtimox verificou-se uma negativação relativamente a somente um ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Droga ENVELOPE(6.521,6.521,62.644,62.644) Revista do Instituto de Medicina Tropical de São Paulo 38 1 35 38 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Chronic Chagas' disease Antiparasitic treatment Benznidazole Nifurtimox Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Chronic Chagas' disease Antiparasitic treatment Benznidazole Nifurtimox Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Guido Carlos Levi Isa Maria Fraga Lobo Esper Georges Kallás Vicente Amato Neto Etiological drug treatment of human infection by Trypanosoma cruzi Tratamento etiológico por droga da infecção humana pelo Trypanosoma cruzi |
topic_facet |
Chronic Chagas' disease Antiparasitic treatment Benznidazole Nifurtimox Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Forty-nine American Trypanosomiasis (Chagas' disease) patients, with xenodiagnosis proven parasitemia were treated by the authors. Forty-one of these patients were given benznidazole, at dosages ranging from 5mg/kg/day to 8mg/kg/day, during a pre-established period of 60 days. In this group, 17 patients had an undetermined form of the disease, whereas 22 had cardiologic disease and 4 had digestive disease (two patients had a mixed form of the disease). Side effects were frequent, and led to the discontinuation of treatment in 17 patients. The follow-up period ranged from 1 to 20 years (mean follow-up period of 6 yrs. 7 mo). 26 (63.4%) of the patients became parasitemia-negative. The other eight patients were treated with nifurtimox, during 120 days, following a variable dose regime of 5mg/kg/day (initial dose) to 17 mg/kg/day (final dose). Six of them had severe side effects, and only one patient remained parasitemia-negative throughout the observation period (ranging from 1 to 18 years). Benznidazole proved to be better tolerated and more effective in the management of parasitemia when compared to nifurtimox, although more effective and less toxic drugs are still desirable. Por meio do benznidazol e do nifurtimox foram tratados 49 pacientes acometidos de doença de Chagas. Xenodiagnóstico prévio tinha sempre resultado positivo, evidenciando parasitemia pelo Trypanosoma cruzi e sendo as seguintes as formas clínicas: indeterminada-19; cardíaca-28; digestiva-4 (dois pacientes apresentavam formas mistas). Quanto ao benznidazol, houve administração de 5 a 8 mg/kg/dia, durante dois meses, e a propósito do nifurtimox o esquema terapêutico começou com a dose de 5 a 7 mg/kg/dia, sucedendo aumento progressivo até 15 a 17 mg/kg/dia, no decurso de quatro meses. O benznidazol, usado por 41 doentes, propiciou negativação em 26 (63.4%) à avaliação realizada por meio do xenodiagnóstico, em etapas de um a 20 anos e, em média, de 6 a 7 anos. Por seu turno, com o nifurtimox verificou-se uma negativação relativamente a somente um ... |
format |
Article in Journal/Newspaper |
author |
Guido Carlos Levi Isa Maria Fraga Lobo Esper Georges Kallás Vicente Amato Neto |
author_facet |
Guido Carlos Levi Isa Maria Fraga Lobo Esper Georges Kallás Vicente Amato Neto |
author_sort |
Guido Carlos Levi |
title |
Etiological drug treatment of human infection by Trypanosoma cruzi Tratamento etiológico por droga da infecção humana pelo Trypanosoma cruzi |
title_short |
Etiological drug treatment of human infection by Trypanosoma cruzi Tratamento etiológico por droga da infecção humana pelo Trypanosoma cruzi |
title_full |
Etiological drug treatment of human infection by Trypanosoma cruzi Tratamento etiológico por droga da infecção humana pelo Trypanosoma cruzi |
title_fullStr |
Etiological drug treatment of human infection by Trypanosoma cruzi Tratamento etiológico por droga da infecção humana pelo Trypanosoma cruzi |
title_full_unstemmed |
Etiological drug treatment of human infection by Trypanosoma cruzi Tratamento etiológico por droga da infecção humana pelo Trypanosoma cruzi |
title_sort |
etiological drug treatment of human infection by trypanosoma cruzi tratamento etiológico por droga da infecção humana pelo trypanosoma cruzi |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1996 |
url |
https://doi.org/10.1590/S0036-46651996000100007 https://doaj.org/article/d43063417707490693aac59bee335dfb |
long_lat |
ENVELOPE(6.521,6.521,62.644,62.644) |
geographic |
Arctic Droga |
geographic_facet |
Arctic Droga |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 38, Iss 1, Pp 35-38 (1996) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651996000100007 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651996000100007 0036-4665 1678-9946 https://doaj.org/article/d43063417707490693aac59bee335dfb |
op_doi |
https://doi.org/10.1590/S0036-46651996000100007 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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38 |
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35 |
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