Microbes increase thermal sensitivity in the mosquito Aedes aegypti, with the potential to change disease distributions.
The mosquito Aedes aegypti is the primary vector of many disease-causing viruses, including dengue (DENV), Zika, chikungunya, and yellow fever. As consequences of climate change, we expect an increase in both global mean temperatures and extreme climatic events. When temperatures fluctuate, mosquito...
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ftdoajarticles:oai:doaj.org/article:d3ce07239ef342b788758b432bb2d720 2023-05-15T15:09:59+02:00 Microbes increase thermal sensitivity in the mosquito Aedes aegypti, with the potential to change disease distributions. Fhallon Ware-Gilmore Carla M Sgrò Zhiyong Xi Heverton L C Dutra Matthew J Jones Katriona Shea Matthew D Hall Matthew B Thomas Elizabeth A McGraw 2021-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009548 https://doaj.org/article/d3ce07239ef342b788758b432bb2d720 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009548 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009548 https://doaj.org/article/d3ce07239ef342b788758b432bb2d720 PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009548 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009548 2022-12-31T08:04:57Z The mosquito Aedes aegypti is the primary vector of many disease-causing viruses, including dengue (DENV), Zika, chikungunya, and yellow fever. As consequences of climate change, we expect an increase in both global mean temperatures and extreme climatic events. When temperatures fluctuate, mosquito vectors will be increasingly exposed to temperatures beyond their upper thermal limits. Here, we examine how DENV infection alters Ae. aegypti thermotolerance by using a high-throughput physiological 'knockdown' assay modeled on studies in Drosophila. Such laboratory measures of thermal tolerance have previously been shown to accurately predict an insect's distribution in the field. We show that DENV infection increases thermal sensitivity, an effect that may ultimately limit the geographic range of the virus. We also show that the endosymbiotic bacterium Wolbachia pipientis, which is currently being released globally as a biological control agent, has a similar impact on thermal sensitivity in Ae. aegypti. Surprisingly, in the coinfected state, Wolbachia did not provide protection against DENV-associated effects on thermal tolerance, nor were the effects of the two infections additive. The latter suggests that the microbes may act by similar means, potentially through activation of shared immune pathways or energetic tradeoffs. Models predicting future ranges of both virus transmission and Wolbachia's efficacy following field release may wish to consider the effects these microbes have on host survival. Article in Journal/Newspaper Arctic Climate change Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 7 e0009548 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Fhallon Ware-Gilmore Carla M Sgrò Zhiyong Xi Heverton L C Dutra Matthew J Jones Katriona Shea Matthew D Hall Matthew B Thomas Elizabeth A McGraw Microbes increase thermal sensitivity in the mosquito Aedes aegypti, with the potential to change disease distributions. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The mosquito Aedes aegypti is the primary vector of many disease-causing viruses, including dengue (DENV), Zika, chikungunya, and yellow fever. As consequences of climate change, we expect an increase in both global mean temperatures and extreme climatic events. When temperatures fluctuate, mosquito vectors will be increasingly exposed to temperatures beyond their upper thermal limits. Here, we examine how DENV infection alters Ae. aegypti thermotolerance by using a high-throughput physiological 'knockdown' assay modeled on studies in Drosophila. Such laboratory measures of thermal tolerance have previously been shown to accurately predict an insect's distribution in the field. We show that DENV infection increases thermal sensitivity, an effect that may ultimately limit the geographic range of the virus. We also show that the endosymbiotic bacterium Wolbachia pipientis, which is currently being released globally as a biological control agent, has a similar impact on thermal sensitivity in Ae. aegypti. Surprisingly, in the coinfected state, Wolbachia did not provide protection against DENV-associated effects on thermal tolerance, nor were the effects of the two infections additive. The latter suggests that the microbes may act by similar means, potentially through activation of shared immune pathways or energetic tradeoffs. Models predicting future ranges of both virus transmission and Wolbachia's efficacy following field release may wish to consider the effects these microbes have on host survival. |
format |
Article in Journal/Newspaper |
author |
Fhallon Ware-Gilmore Carla M Sgrò Zhiyong Xi Heverton L C Dutra Matthew J Jones Katriona Shea Matthew D Hall Matthew B Thomas Elizabeth A McGraw |
author_facet |
Fhallon Ware-Gilmore Carla M Sgrò Zhiyong Xi Heverton L C Dutra Matthew J Jones Katriona Shea Matthew D Hall Matthew B Thomas Elizabeth A McGraw |
author_sort |
Fhallon Ware-Gilmore |
title |
Microbes increase thermal sensitivity in the mosquito Aedes aegypti, with the potential to change disease distributions. |
title_short |
Microbes increase thermal sensitivity in the mosquito Aedes aegypti, with the potential to change disease distributions. |
title_full |
Microbes increase thermal sensitivity in the mosquito Aedes aegypti, with the potential to change disease distributions. |
title_fullStr |
Microbes increase thermal sensitivity in the mosquito Aedes aegypti, with the potential to change disease distributions. |
title_full_unstemmed |
Microbes increase thermal sensitivity in the mosquito Aedes aegypti, with the potential to change disease distributions. |
title_sort |
microbes increase thermal sensitivity in the mosquito aedes aegypti, with the potential to change disease distributions. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009548 https://doaj.org/article/d3ce07239ef342b788758b432bb2d720 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Climate change |
genre_facet |
Arctic Climate change |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009548 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009548 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009548 https://doaj.org/article/d3ce07239ef342b788758b432bb2d720 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009548 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
7 |
container_start_page |
e0009548 |
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1766341071161262080 |