Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Paul J Converse, Sandeep Tyagi, Yalan Xing, Si-Yang Li, Yoshito Kishi, John Adamson, Eric L Nuermberger, Jacques H Grosset
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2015
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Rif
• Online Access: https://doi.org/10.1371/journal.pntd.0003823; https://doaj.org/article/d3a1fd958498456cba69bdab155369a4

Treatment of Buruli ulcer, or Mycobacterium ulcerans disease, has shifted from surgical excision and skin grafting to antibiotic therapy usually with 8 weeks of daily rifampin (RIF) and streptomycin (STR). Although the results have been highly favorable, administration of STR requires intramuscular...