Patients with chronic hepatitis C and normal transaminases Pacientes com hepatite C crônica e transaminases normais
Hepatitis C virus infection evolves progressively persisting in the majority of patients (85%). Most patients have high ALT (alanine aminotransferase) levels and approximately 25% normal ALT. The latter are usually female and there is no association between genotype and severity of hepatic lesion. H...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Universidade de São Paulo (USP)
2005
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ftdoajarticles:oai:doaj.org/article:d35fd797f00c4246aa187798363f2caa 2024-09-09T19:28:23+00:00 Patients with chronic hepatitis C and normal transaminases Pacientes com hepatite C crônica e transaminases normais Haydée Marina do Valle Pereira Norma de Paula Cavalheiro Fátima Mitiko Tengan Carlos Eduardo Melo Evandro Sobroza Mello Antônio Alci Barone 2005-10-01T00:00:00Z https://doi.org/10.1590/S0036-46652005000500002 https://doaj.org/article/d35fd797f00c4246aa187798363f2caa EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652005000500002 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652005000500002 0036-4665 1678-9946 https://doaj.org/article/d35fd797f00c4246aa187798363f2caa Revista do Instituto de Medicina Tropical de São Paulo, Vol 47, Iss 5, Pp 247-251 (2005) Hepatitis C Normal transaminases Biopsy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2005 ftdoajarticles https://doi.org/10.1590/S0036-46652005000500002 2024-08-05T17:49:31Z Hepatitis C virus infection evolves progressively persisting in the majority of patients (85%). Most patients have high ALT (alanine aminotransferase) levels and approximately 25% normal ALT. The latter are usually female and there is no association between genotype and severity of hepatic lesion. Histologic analysis usually shows small lesion and absence or low amount of fibrosis, despite cirrhosis having been reported. Aiming at assessing prevalence, demographic, genotypical and anatomopathological characteristics in patients with normal ALT levels, we have carried out a study of 68 chronic hepatitis C patients between January 1997 and April 2000. There was a prevalence of 13.8% chronic hepatitis C patients with normal ALT levels, 45.6% of which were male and 54.4% female, the mean age being 38 +/- 13 years. We found a predominance of genotype 1 in 84.7% of the patients, genotype 2 in 6.8% and genotype 3 in 10.7%. In 52.9% of the cases liver biopsies revealed liver reaction, periportal activity score 0-1 was observed in 85.3% of the patients and score 2-4 was seen in 14.7%. Structural activity score 0-1 was seen in 73.5% of the patients and score 2-4 in 26.5% of them. Periportal activity > 2 and structural activity > 1 was seen in 29%, but steatosis was not seen in 73.5%. Our results suggest the need to revisit for liver biopsy practice in patients with Chronic Hepatitis C and normal transaminases. Hepatite C é uma doença de evolução progressiva. A maioria dos pacientes tem nível de ALT elevada e 25% apresentam níveis normais. Os com ALT normal geralmente são do gênero feminino e sem associação entre genótipo e gravidade de lesão hepática. O exame histopatológico mostra geralmente ausência de ou leve fibrose (cerca de 20% tem fibrose), embora cirrose já tenha sido relatada. Visando estimar a prevalência, características demográficas, genotípicas e anatomopatológicas em pacientes com ALT normal, realizamos um estudo de série com 68 casos com diagnóstico de hepatite C crônica. Os pacientes foram ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 47 5 247 251 |
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Hepatitis C Normal transaminases Biopsy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Hepatitis C Normal transaminases Biopsy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Haydée Marina do Valle Pereira Norma de Paula Cavalheiro Fátima Mitiko Tengan Carlos Eduardo Melo Evandro Sobroza Mello Antônio Alci Barone Patients with chronic hepatitis C and normal transaminases Pacientes com hepatite C crônica e transaminases normais |
topic_facet |
Hepatitis C Normal transaminases Biopsy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Hepatitis C virus infection evolves progressively persisting in the majority of patients (85%). Most patients have high ALT (alanine aminotransferase) levels and approximately 25% normal ALT. The latter are usually female and there is no association between genotype and severity of hepatic lesion. Histologic analysis usually shows small lesion and absence or low amount of fibrosis, despite cirrhosis having been reported. Aiming at assessing prevalence, demographic, genotypical and anatomopathological characteristics in patients with normal ALT levels, we have carried out a study of 68 chronic hepatitis C patients between January 1997 and April 2000. There was a prevalence of 13.8% chronic hepatitis C patients with normal ALT levels, 45.6% of which were male and 54.4% female, the mean age being 38 +/- 13 years. We found a predominance of genotype 1 in 84.7% of the patients, genotype 2 in 6.8% and genotype 3 in 10.7%. In 52.9% of the cases liver biopsies revealed liver reaction, periportal activity score 0-1 was observed in 85.3% of the patients and score 2-4 was seen in 14.7%. Structural activity score 0-1 was seen in 73.5% of the patients and score 2-4 in 26.5% of them. Periportal activity > 2 and structural activity > 1 was seen in 29%, but steatosis was not seen in 73.5%. Our results suggest the need to revisit for liver biopsy practice in patients with Chronic Hepatitis C and normal transaminases. Hepatite C é uma doença de evolução progressiva. A maioria dos pacientes tem nível de ALT elevada e 25% apresentam níveis normais. Os com ALT normal geralmente são do gênero feminino e sem associação entre genótipo e gravidade de lesão hepática. O exame histopatológico mostra geralmente ausência de ou leve fibrose (cerca de 20% tem fibrose), embora cirrose já tenha sido relatada. Visando estimar a prevalência, características demográficas, genotípicas e anatomopatológicas em pacientes com ALT normal, realizamos um estudo de série com 68 casos com diagnóstico de hepatite C crônica. Os pacientes foram ... |
format |
Article in Journal/Newspaper |
author |
Haydée Marina do Valle Pereira Norma de Paula Cavalheiro Fátima Mitiko Tengan Carlos Eduardo Melo Evandro Sobroza Mello Antônio Alci Barone |
author_facet |
Haydée Marina do Valle Pereira Norma de Paula Cavalheiro Fátima Mitiko Tengan Carlos Eduardo Melo Evandro Sobroza Mello Antônio Alci Barone |
author_sort |
Haydée Marina do Valle Pereira |
title |
Patients with chronic hepatitis C and normal transaminases Pacientes com hepatite C crônica e transaminases normais |
title_short |
Patients with chronic hepatitis C and normal transaminases Pacientes com hepatite C crônica e transaminases normais |
title_full |
Patients with chronic hepatitis C and normal transaminases Pacientes com hepatite C crônica e transaminases normais |
title_fullStr |
Patients with chronic hepatitis C and normal transaminases Pacientes com hepatite C crônica e transaminases normais |
title_full_unstemmed |
Patients with chronic hepatitis C and normal transaminases Pacientes com hepatite C crônica e transaminases normais |
title_sort |
patients with chronic hepatitis c and normal transaminases pacientes com hepatite c crônica e transaminases normais |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2005 |
url |
https://doi.org/10.1590/S0036-46652005000500002 https://doaj.org/article/d35fd797f00c4246aa187798363f2caa |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 47, Iss 5, Pp 247-251 (2005) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652005000500002 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652005000500002 0036-4665 1678-9946 https://doaj.org/article/d35fd797f00c4246aa187798363f2caa |
op_doi |
https://doi.org/10.1590/S0036-46652005000500002 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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