In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds
Abstract During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey. This venom offers a unique and extensive source of chemical diver...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Online Access: | https://doi.org/10.1186/s40409-016-0083-6 https://doaj.org/article/d2f429edcc9d4a21b7a82303b9c130f0 |
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ftdoajarticles:oai:doaj.org/article:d2f429edcc9d4a21b7a82303b9c130f0 2023-05-15T15:06:44+02:00 In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds Eline K. M. Lebbe Jan Tytgat 2016-12-01T00:00:00Z https://doi.org/10.1186/s40409-016-0083-6 https://doaj.org/article/d2f429edcc9d4a21b7a82303b9c130f0 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100203&lng=en&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1186/s40409-016-0083-6 https://doaj.org/article/d2f429edcc9d4a21b7a82303b9c130f0 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 22, Iss 0 (2016) Cone snail Conopressin Contryphan Conantokin Contulakin Conorfamid Conophan Conomap Conomarphin Conolysin ConoGAY ConoCAP Cono-NPY Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2016 ftdoajarticles https://doi.org/10.1186/s40409-016-0083-6 2022-12-31T15:53:13Z Abstract During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey. This venom offers a unique and extensive source of chemical diversity as it is driven by the evolutionary pressure to improve prey capture and/or to protect their species. Cone snail venom is an example of the remarkable diversity in pharmacologically active small peptides that venoms can consist of. These venom peptides, called conopeptides, are classified into two main groups based on the number of cysteine residues, namely disulfide-rich and disulfide-poor conopeptides. Since disulfide-poor conotoxins are minor components of this venom cocktail, the number of identified peptides and the characterization of these peptides is far outclassed by its cysteine-rich equivalents. This review provides an overview of 12 families of disulfide-poor peptides identified to date as well as the state of affairs. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Cono ENVELOPE(-58.500,-58.500,-62.067,-62.067) Journal of Venomous Animals and Toxins including Tropical Diseases 22 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Cone snail Conopressin Contryphan Conantokin Contulakin Conorfamid Conophan Conomap Conomarphin Conolysin ConoGAY ConoCAP Cono-NPY Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Cone snail Conopressin Contryphan Conantokin Contulakin Conorfamid Conophan Conomap Conomarphin Conolysin ConoGAY ConoCAP Cono-NPY Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Eline K. M. Lebbe Jan Tytgat In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
topic_facet |
Cone snail Conopressin Contryphan Conantokin Contulakin Conorfamid Conophan Conomap Conomarphin Conolysin ConoGAY ConoCAP Cono-NPY Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey. This venom offers a unique and extensive source of chemical diversity as it is driven by the evolutionary pressure to improve prey capture and/or to protect their species. Cone snail venom is an example of the remarkable diversity in pharmacologically active small peptides that venoms can consist of. These venom peptides, called conopeptides, are classified into two main groups based on the number of cysteine residues, namely disulfide-rich and disulfide-poor conopeptides. Since disulfide-poor conotoxins are minor components of this venom cocktail, the number of identified peptides and the characterization of these peptides is far outclassed by its cysteine-rich equivalents. This review provides an overview of 12 families of disulfide-poor peptides identified to date as well as the state of affairs. |
format |
Article in Journal/Newspaper |
author |
Eline K. M. Lebbe Jan Tytgat |
author_facet |
Eline K. M. Lebbe Jan Tytgat |
author_sort |
Eline K. M. Lebbe |
title |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
title_short |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
title_full |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
title_fullStr |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
title_full_unstemmed |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
title_sort |
in the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
publisher |
SciELO |
publishDate |
2016 |
url |
https://doi.org/10.1186/s40409-016-0083-6 https://doaj.org/article/d2f429edcc9d4a21b7a82303b9c130f0 |
long_lat |
ENVELOPE(-58.500,-58.500,-62.067,-62.067) |
geographic |
Arctic Cono |
geographic_facet |
Arctic Cono |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 22, Iss 0 (2016) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100203&lng=en&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1186/s40409-016-0083-6 https://doaj.org/article/d2f429edcc9d4a21b7a82303b9c130f0 |
op_doi |
https://doi.org/10.1186/s40409-016-0083-6 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
22 |
container_issue |
1 |
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1766338290141626368 |