Circumsporozoite Surface Protein-based malaria vaccines: a review
ABSTRACT Malaria represents a serious public health problem, presenting with high rates of incidence, morbidity and mortality in tropical and subtropical regions of the world. According to the World Health Organization, in 2018 there were 228 million cases and 405 thousand deaths caused by this dise...
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ftdoajarticles:oai:doaj.org/article:d2ac05b0b0a747d69783e129a3337cfa 2024-09-09T19:26:22+00:00 Circumsporozoite Surface Protein-based malaria vaccines: a review Maria Edilene Martins de Almeida Maria Gabriella Santos de Vasconcelos Andréa Monteiro Tarragô Luís André Morais Mariúba 2021-01-01T00:00:00Z https://doi.org/10.1590/s1678-9946202163011 https://doaj.org/article/d2ac05b0b0a747d69783e129a3337cfa EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652021000100400&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946202163011 https://doaj.org/article/d2ac05b0b0a747d69783e129a3337cfa Revista do Instituto de Medicina Tropical de São Paulo, Vol 63 (2021) Malaria Vaccine Adjuvant Circumsporozoite Surface Protein Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1590/s1678-9946202163011 2024-08-05T17:49:31Z ABSTRACT Malaria represents a serious public health problem, presenting with high rates of incidence, morbidity and mortality in tropical and subtropical regions of the world. According to the World Health Organization, in 2018 there were 228 million cases and 405 thousand deaths caused by this disease in the world, affecting mainly children and pregnant women in Africa. Despite the programs carried out to control this disease, drug resistance and invertebrate vector resistance to insecticides have generated difficulties. An efficient vaccine against malaria would be a strategy with a high impact on the eradication and control of this disease. Researches aimed at developing vaccines have focused on antigens of high importance for the survival of the parasite such as the Circumsporozoite Surface Protein, involved in the pre-erythrocytic cycle during parasites invasion in hepatocytes. Currently, RTS’S is the most promising vaccine for malaria and was constructed using CSP; its performance was evaluated using two types of adjuvants: AS01 and AS02. The purpose of this review was to provide a bibliographic survey of historical researches that led to the development of RTS’S and its performance analysis over the decade. The search for new adjuvants to be associated with this antigen seems to be a way to obtain higher percentages of protection for a future malaria vaccine. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 63 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Vaccine Adjuvant Circumsporozoite Surface Protein Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Vaccine Adjuvant Circumsporozoite Surface Protein Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Maria Edilene Martins de Almeida Maria Gabriella Santos de Vasconcelos Andréa Monteiro Tarragô Luís André Morais Mariúba Circumsporozoite Surface Protein-based malaria vaccines: a review |
topic_facet |
Malaria Vaccine Adjuvant Circumsporozoite Surface Protein Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
ABSTRACT Malaria represents a serious public health problem, presenting with high rates of incidence, morbidity and mortality in tropical and subtropical regions of the world. According to the World Health Organization, in 2018 there were 228 million cases and 405 thousand deaths caused by this disease in the world, affecting mainly children and pregnant women in Africa. Despite the programs carried out to control this disease, drug resistance and invertebrate vector resistance to insecticides have generated difficulties. An efficient vaccine against malaria would be a strategy with a high impact on the eradication and control of this disease. Researches aimed at developing vaccines have focused on antigens of high importance for the survival of the parasite such as the Circumsporozoite Surface Protein, involved in the pre-erythrocytic cycle during parasites invasion in hepatocytes. Currently, RTS’S is the most promising vaccine for malaria and was constructed using CSP; its performance was evaluated using two types of adjuvants: AS01 and AS02. The purpose of this review was to provide a bibliographic survey of historical researches that led to the development of RTS’S and its performance analysis over the decade. The search for new adjuvants to be associated with this antigen seems to be a way to obtain higher percentages of protection for a future malaria vaccine. |
format |
Article in Journal/Newspaper |
author |
Maria Edilene Martins de Almeida Maria Gabriella Santos de Vasconcelos Andréa Monteiro Tarragô Luís André Morais Mariúba |
author_facet |
Maria Edilene Martins de Almeida Maria Gabriella Santos de Vasconcelos Andréa Monteiro Tarragô Luís André Morais Mariúba |
author_sort |
Maria Edilene Martins de Almeida |
title |
Circumsporozoite Surface Protein-based malaria vaccines: a review |
title_short |
Circumsporozoite Surface Protein-based malaria vaccines: a review |
title_full |
Circumsporozoite Surface Protein-based malaria vaccines: a review |
title_fullStr |
Circumsporozoite Surface Protein-based malaria vaccines: a review |
title_full_unstemmed |
Circumsporozoite Surface Protein-based malaria vaccines: a review |
title_sort |
circumsporozoite surface protein-based malaria vaccines: a review |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2021 |
url |
https://doi.org/10.1590/s1678-9946202163011 https://doaj.org/article/d2ac05b0b0a747d69783e129a3337cfa |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 63 (2021) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652021000100400&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946202163011 https://doaj.org/article/d2ac05b0b0a747d69783e129a3337cfa |
op_doi |
https://doi.org/10.1590/s1678-9946202163011 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
63 |
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1809895999770984448 |