Incidence of Herpes simplex Virus Infection in Patients with Acute Central Nervous System Infections
Herpes simplex viruses are agents responsible for a variety of infections on buccal and genital mucosa; they are neurotropic, capable of lodging in the nerve cells and remaining latent with subsequent reactivations; in some cases, they can provoke meningitis and encephalitis; and they have a signifi...
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Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales
2010
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ftdoajarticles:oai:doaj.org/article:d29b5cd669a8485598575b917a883bff 2023-10-09T21:49:08+02:00 Incidence of Herpes simplex Virus Infection in Patients with Acute Central Nervous System Infections Kriss Pérez Leticia Porto Espinoza Raimy Mindiola Diana Callejas Jesús Estévez Reyna Moronta 2010-08-01T00:00:00Z https://doaj.org/article/d29b5cd669a8485598575b917a883bff EN ES eng spa Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales https://produccioncientificaluz.org/index.php/kasmera/article/view/4864 https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/d29b5cd669a8485598575b917a883bff Kasmera, Vol 38, Iss 2, Pp 147-156 (2010) herpesvirus meningitis encefalitis líquido cefalorraquídeo (LCR) suero anticuerpos Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles 2023-09-10T00:47:59Z Herpes simplex viruses are agents responsible for a variety of infections on buccal and genital mucosa; they are neurotropic, capable of lodging in the nerve cells and remaining latent with subsequent reactivations; in some cases, they can provoke meningitis and encephalitis; and they have a significant morbidity and are associated with a high mortality. The present project aims to determine HSV’s effect on the etiology of acute central nervous system (CNS) syndromes using the detection of specific antibodies in serum and cerebrospinal fluid. The 93 paired samples from patients with neurological affectations studied demonstrated negative results in the LCR bacteriological study and their Alb-LCR/Alb-serum relation was < 0.0075. Antibodies were detected by the enzymatic immunoassay ELISA method, where 1.2% (1/93) of the serum samples turned out positive for IgM; 89.24% (83/93) of the serum samples resulted positive for IgG; and 27.39% (20/93) of LCR samples were positive for anti-IgG. IgG presence in LCR suggested the intrathecal production of these antibodies inside the CNS, which demonstrates a significant participation by this viral agent in infections and diseases associated with the CNS. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish |
topic |
herpesvirus meningitis encefalitis líquido cefalorraquídeo (LCR) suero anticuerpos Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
herpesvirus meningitis encefalitis líquido cefalorraquídeo (LCR) suero anticuerpos Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Kriss Pérez Leticia Porto Espinoza Raimy Mindiola Diana Callejas Jesús Estévez Reyna Moronta Incidence of Herpes simplex Virus Infection in Patients with Acute Central Nervous System Infections |
topic_facet |
herpesvirus meningitis encefalitis líquido cefalorraquídeo (LCR) suero anticuerpos Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Herpes simplex viruses are agents responsible for a variety of infections on buccal and genital mucosa; they are neurotropic, capable of lodging in the nerve cells and remaining latent with subsequent reactivations; in some cases, they can provoke meningitis and encephalitis; and they have a significant morbidity and are associated with a high mortality. The present project aims to determine HSV’s effect on the etiology of acute central nervous system (CNS) syndromes using the detection of specific antibodies in serum and cerebrospinal fluid. The 93 paired samples from patients with neurological affectations studied demonstrated negative results in the LCR bacteriological study and their Alb-LCR/Alb-serum relation was < 0.0075. Antibodies were detected by the enzymatic immunoassay ELISA method, where 1.2% (1/93) of the serum samples turned out positive for IgM; 89.24% (83/93) of the serum samples resulted positive for IgG; and 27.39% (20/93) of LCR samples were positive for anti-IgG. IgG presence in LCR suggested the intrathecal production of these antibodies inside the CNS, which demonstrates a significant participation by this viral agent in infections and diseases associated with the CNS. |
format |
Article in Journal/Newspaper |
author |
Kriss Pérez Leticia Porto Espinoza Raimy Mindiola Diana Callejas Jesús Estévez Reyna Moronta |
author_facet |
Kriss Pérez Leticia Porto Espinoza Raimy Mindiola Diana Callejas Jesús Estévez Reyna Moronta |
author_sort |
Kriss Pérez |
title |
Incidence of Herpes simplex Virus Infection in Patients with Acute Central Nervous System Infections |
title_short |
Incidence of Herpes simplex Virus Infection in Patients with Acute Central Nervous System Infections |
title_full |
Incidence of Herpes simplex Virus Infection in Patients with Acute Central Nervous System Infections |
title_fullStr |
Incidence of Herpes simplex Virus Infection in Patients with Acute Central Nervous System Infections |
title_full_unstemmed |
Incidence of Herpes simplex Virus Infection in Patients with Acute Central Nervous System Infections |
title_sort |
incidence of herpes simplex virus infection in patients with acute central nervous system infections |
publisher |
Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales |
publishDate |
2010 |
url |
https://doaj.org/article/d29b5cd669a8485598575b917a883bff |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Kasmera, Vol 38, Iss 2, Pp 147-156 (2010) |
op_relation |
https://produccioncientificaluz.org/index.php/kasmera/article/view/4864 https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/d29b5cd669a8485598575b917a883bff |
_version_ |
1779312170345955328 |