The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs
The hemorrhagic syndrome of leptospirosis was studied in guinea pigs. The study correlates hematological, histopathological and immunohistochemical alterations in sixty animals inoculated by the intraperitoneal route with lml of the culture of virulent strain of Leptospira interrogans serovar copenh...
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Sociedade Brasileira de Medicina Tropical (SBMT)
1995
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ftdoajarticles:oai:doaj.org/article:d287abaf74eb4171914090ccefadddca 2023-05-15T15:11:28+02:00 The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs João José Pereira da Silva Bernardino Alves de Souza Netto Walter Lilembaum Maria Erbene Amorim Melo Alvim Albanita Viana de Oliveira 1995-09-01T00:00:00Z https://doaj.org/article/d287abaf74eb4171914090ccefadddca EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821995000300002 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/d287abaf74eb4171914090ccefadddca Revista da Sociedade Brasileira de Medicina Tropical, Vol 28, Iss 3, Pp 169-177 (1995) Leptospirose Síndrome hemorrágica Plaquetopenia. Coagulação intravascular disseminada CIVD Imunoperoxidase Leptospirosis Hemorrhagic syndrome Platelet depletion Immunoperoxidase Disseminated intravascular coagulation DIC Arctic medicine. Tropical medicine RC955-962 article 1995 ftdoajarticles 2022-12-31T03:05:22Z The hemorrhagic syndrome of leptospirosis was studied in guinea pigs. The study correlates hematological, histopathological and immunohistochemical alterations in sixty animals inoculated by the intraperitoneal route with lml of the culture of virulent strain of Leptospira interrogans serovar copenhageni. Leptospirae antigens were detected by immunoperoxidase, chiefly in liver, kidney and heart muscle capillaries. Possible pathogenic mechanisms responsible for hemorrhagic syndrome are discussed with emphasis on toxic and anoxic attacks causing damage to endothelia, platelet depletion and alterations to hemostasia rates: prothrombin time [FT], partial thromboplastin time [PIT] and fibrinogen concentrations. Tide clinical-laboratoiy picture is compatible with the histopathological observation of disseminated intravascular coagulation [D1C] in most of the guinea pigs from day 4 of infection. Os autores estudam a síndrome hemorrágica da leptospirose em cobaios inoculados com amostra virulenta de Leptospira interrogans sorovar copenhageni. São abordados aspectos hematológicos, hístopatolôgicos e imuno- histoquímicos. Aumento do tempo de protrombina (PT) e do tempo parcial tromboplastina (PTT), bem como redução do número de plaquetas e do fibrinogênio acompanharam-se de congestão vascular, hemorragias e coagulação intravascular no fígado, rim, coração, músculo esquelético e pulmão. O antígetzo de Leptospira foi detectado principalmente em tecido hepático, renal e cardíaco. São discutidos possíveis mecanismos patogênicos responsáveis pela síndrome hemorrágica, com ênfase na agressão tóxico- anóxica do endotêlio vascular, que propiciaria a instalação de coagulação intravascular disseminada (CIVD) observada, sobretudo, nos cobaios dos grupos 4, 5 e 6. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Leptospirose Síndrome hemorrágica Plaquetopenia. Coagulação intravascular disseminada CIVD Imunoperoxidase Leptospirosis Hemorrhagic syndrome Platelet depletion Immunoperoxidase Disseminated intravascular coagulation DIC Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Leptospirose Síndrome hemorrágica Plaquetopenia. Coagulação intravascular disseminada CIVD Imunoperoxidase Leptospirosis Hemorrhagic syndrome Platelet depletion Immunoperoxidase Disseminated intravascular coagulation DIC Arctic medicine. Tropical medicine RC955-962 João José Pereira da Silva Bernardino Alves de Souza Netto Walter Lilembaum Maria Erbene Amorim Melo Alvim Albanita Viana de Oliveira The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs |
topic_facet |
Leptospirose Síndrome hemorrágica Plaquetopenia. Coagulação intravascular disseminada CIVD Imunoperoxidase Leptospirosis Hemorrhagic syndrome Platelet depletion Immunoperoxidase Disseminated intravascular coagulation DIC Arctic medicine. Tropical medicine RC955-962 |
description |
The hemorrhagic syndrome of leptospirosis was studied in guinea pigs. The study correlates hematological, histopathological and immunohistochemical alterations in sixty animals inoculated by the intraperitoneal route with lml of the culture of virulent strain of Leptospira interrogans serovar copenhageni. Leptospirae antigens were detected by immunoperoxidase, chiefly in liver, kidney and heart muscle capillaries. Possible pathogenic mechanisms responsible for hemorrhagic syndrome are discussed with emphasis on toxic and anoxic attacks causing damage to endothelia, platelet depletion and alterations to hemostasia rates: prothrombin time [FT], partial thromboplastin time [PIT] and fibrinogen concentrations. Tide clinical-laboratoiy picture is compatible with the histopathological observation of disseminated intravascular coagulation [D1C] in most of the guinea pigs from day 4 of infection. Os autores estudam a síndrome hemorrágica da leptospirose em cobaios inoculados com amostra virulenta de Leptospira interrogans sorovar copenhageni. São abordados aspectos hematológicos, hístopatolôgicos e imuno- histoquímicos. Aumento do tempo de protrombina (PT) e do tempo parcial tromboplastina (PTT), bem como redução do número de plaquetas e do fibrinogênio acompanharam-se de congestão vascular, hemorragias e coagulação intravascular no fígado, rim, coração, músculo esquelético e pulmão. O antígetzo de Leptospira foi detectado principalmente em tecido hepático, renal e cardíaco. São discutidos possíveis mecanismos patogênicos responsáveis pela síndrome hemorrágica, com ênfase na agressão tóxico- anóxica do endotêlio vascular, que propiciaria a instalação de coagulação intravascular disseminada (CIVD) observada, sobretudo, nos cobaios dos grupos 4, 5 e 6. |
format |
Article in Journal/Newspaper |
author |
João José Pereira da Silva Bernardino Alves de Souza Netto Walter Lilembaum Maria Erbene Amorim Melo Alvim Albanita Viana de Oliveira |
author_facet |
João José Pereira da Silva Bernardino Alves de Souza Netto Walter Lilembaum Maria Erbene Amorim Melo Alvim Albanita Viana de Oliveira |
author_sort |
João José Pereira da Silva |
title |
The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs |
title_short |
The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs |
title_full |
The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs |
title_fullStr |
The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs |
title_full_unstemmed |
The hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs |
title_sort |
hemorrhagic syndrome of leptospirosis: an experimental study in guinea pigs |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1995 |
url |
https://doaj.org/article/d287abaf74eb4171914090ccefadddca |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 28, Iss 3, Pp 169-177 (1995) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821995000300002 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/d287abaf74eb4171914090ccefadddca |
_version_ |
1766342310628425728 |