Aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections
ABSTRACTINTRODUCTION: This study aimed to determine the frequencies of bacterial isolates cultured from diabetic foot infections and assess their resistance and susceptibility to commonly used antibiotics.METHODS: This prospective study included 41 patients with diabetic foot lesions. Bacteria were...
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ftdoajarticles:oai:doaj.org/article:d265653f3ff843a4b6d8d475f226cf29 2023-05-15T15:13:09+02:00 Aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections Michele Cezimbra Perim Joelma da Costa Borges Stela Regina Costa Celeste Ederson de Freitas Orsolin Rafael Rocha Mendes Gabriella Oliveira Mendes Roumayne Lopes Ferreira Solange Cristina Carreiro Maria Cristina da Silva Pranchevicius 2015-10-01T00:00:00Z https://doi.org/10.1590/0037-8682-0146-2015 https://doaj.org/article/d265653f3ff843a4b6d8d475f226cf29 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000500546&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0146-2015 https://doaj.org/article/d265653f3ff843a4b6d8d475f226cf29 Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 5, Pp 546-554 (2015) Diabetic foot infection Polymicrobial infections Multidrug-resistant organisms Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.1590/0037-8682-0146-2015 2022-12-30T21:38:59Z ABSTRACTINTRODUCTION: This study aimed to determine the frequencies of bacterial isolates cultured from diabetic foot infections and assess their resistance and susceptibility to commonly used antibiotics.METHODS: This prospective study included 41 patients with diabetic foot lesions. Bacteria were isolated from foot lesions, and their antibiotic susceptibility pattern was determined using the Kirby-Bauer disk diffusion method and/or broth method [minimum inhibitory concentration (MIC)].RESULTS: The most common location of ulceration was the toe (54%), followed by the plantar surface (27%) and dorsal portion (19%). A total of 89 bacterial isolates were obtained from 30 patients. The infections were predominantly due to Gram-positive bacteria and polymicrobial bacteremia. The most commonly isolated Gram-positive bacteria were Staphylococcus aureus, followed by Staphylococcus saprophyticus, Staphylococcus epidermidis, Streptococcus agalactiae, and Streptococcus pneumoniae. The most commonly isolated Gram-negative bacteria were Proteus spp. and Enterobacterspp., followed by Escherichia coli, Pseudomonasspp., and Citrobacterspp. Nine cases of methicillin-resistant Staphylococcus aureus (MRSA) had cefoxitin resistance, and among these MRSA isolates, 3 were resistant to vancomycin with the MIC technique. The antibiotic imipenem was the most effective against both Gram-positive and Gram-negative bacteria, and gentamicin was effective against Gram-negative bacteria.CONCLUSIONS: The present study confirmed the high prevalence of multidrug-resistant pathogens in diabetic foot ulcers. It is necessary to evaluate the different microorganisms infecting the wound and to know the antibiotic susceptibility patterns of the isolates from the infected wound. This knowledge is crucial for planning treatment with the appropriate antibiotics, reducing resistance patterns, and minimizing healthcare costs. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic The Toe ENVELOPE(-59.167,-59.167,-62.333,-62.333) Revista da Sociedade Brasileira de Medicina Tropical 48 5 546 554 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Diabetic foot infection Polymicrobial infections Multidrug-resistant organisms Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Diabetic foot infection Polymicrobial infections Multidrug-resistant organisms Arctic medicine. Tropical medicine RC955-962 Michele Cezimbra Perim Joelma da Costa Borges Stela Regina Costa Celeste Ederson de Freitas Orsolin Rafael Rocha Mendes Gabriella Oliveira Mendes Roumayne Lopes Ferreira Solange Cristina Carreiro Maria Cristina da Silva Pranchevicius Aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections |
topic_facet |
Diabetic foot infection Polymicrobial infections Multidrug-resistant organisms Arctic medicine. Tropical medicine RC955-962 |
description |
ABSTRACTINTRODUCTION: This study aimed to determine the frequencies of bacterial isolates cultured from diabetic foot infections and assess their resistance and susceptibility to commonly used antibiotics.METHODS: This prospective study included 41 patients with diabetic foot lesions. Bacteria were isolated from foot lesions, and their antibiotic susceptibility pattern was determined using the Kirby-Bauer disk diffusion method and/or broth method [minimum inhibitory concentration (MIC)].RESULTS: The most common location of ulceration was the toe (54%), followed by the plantar surface (27%) and dorsal portion (19%). A total of 89 bacterial isolates were obtained from 30 patients. The infections were predominantly due to Gram-positive bacteria and polymicrobial bacteremia. The most commonly isolated Gram-positive bacteria were Staphylococcus aureus, followed by Staphylococcus saprophyticus, Staphylococcus epidermidis, Streptococcus agalactiae, and Streptococcus pneumoniae. The most commonly isolated Gram-negative bacteria were Proteus spp. and Enterobacterspp., followed by Escherichia coli, Pseudomonasspp., and Citrobacterspp. Nine cases of methicillin-resistant Staphylococcus aureus (MRSA) had cefoxitin resistance, and among these MRSA isolates, 3 were resistant to vancomycin with the MIC technique. The antibiotic imipenem was the most effective against both Gram-positive and Gram-negative bacteria, and gentamicin was effective against Gram-negative bacteria.CONCLUSIONS: The present study confirmed the high prevalence of multidrug-resistant pathogens in diabetic foot ulcers. It is necessary to evaluate the different microorganisms infecting the wound and to know the antibiotic susceptibility patterns of the isolates from the infected wound. This knowledge is crucial for planning treatment with the appropriate antibiotics, reducing resistance patterns, and minimizing healthcare costs. |
format |
Article in Journal/Newspaper |
author |
Michele Cezimbra Perim Joelma da Costa Borges Stela Regina Costa Celeste Ederson de Freitas Orsolin Rafael Rocha Mendes Gabriella Oliveira Mendes Roumayne Lopes Ferreira Solange Cristina Carreiro Maria Cristina da Silva Pranchevicius |
author_facet |
Michele Cezimbra Perim Joelma da Costa Borges Stela Regina Costa Celeste Ederson de Freitas Orsolin Rafael Rocha Mendes Gabriella Oliveira Mendes Roumayne Lopes Ferreira Solange Cristina Carreiro Maria Cristina da Silva Pranchevicius |
author_sort |
Michele Cezimbra Perim |
title |
Aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections |
title_short |
Aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections |
title_full |
Aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections |
title_fullStr |
Aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections |
title_full_unstemmed |
Aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections |
title_sort |
aerobic bacterial profile and antibiotic resistance in patients with diabetic foot infections |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2015 |
url |
https://doi.org/10.1590/0037-8682-0146-2015 https://doaj.org/article/d265653f3ff843a4b6d8d475f226cf29 |
long_lat |
ENVELOPE(-59.167,-59.167,-62.333,-62.333) |
geographic |
Arctic The Toe |
geographic_facet |
Arctic The Toe |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 5, Pp 546-554 (2015) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000500546&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0146-2015 https://doaj.org/article/d265653f3ff843a4b6d8d475f226cf29 |
op_doi |
https://doi.org/10.1590/0037-8682-0146-2015 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
48 |
container_issue |
5 |
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546 |
op_container_end_page |
554 |
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1766343735769038848 |