Oxidative stress and antioxidants in diabetes mellitus
Numerous studies have implicated oxidative stress in the development of complications of diabetes. During hyperglycemia, production of oxidant agents such as reactive oxygen species and reactive nitrogen species increases. This process, along with a decrease in the activity of antioxidant enzymes, i...
Published in: | Asian Pacific Journal of Tropical Medicine |
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Online Access: | https://doi.org/10.4103/1995-7645.291036 https://doaj.org/article/d252e978a5a94baf99e4f00e36bfecb5 |
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ftdoajarticles:oai:doaj.org/article:d252e978a5a94baf99e4f00e36bfecb5 2023-05-15T15:05:25+02:00 Oxidative stress and antioxidants in diabetes mellitus Maryam Ghasemi-Dehnoo Hossein Amini-Khoei Zahra Lorigooini Mahmoud Rafieian-Kopaei 2020-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.291036 https://doaj.org/article/d252e978a5a94baf99e4f00e36bfecb5 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=10;spage=431;epage=438;aulast=Ghasemi-Dehnoo https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.291036 https://doaj.org/article/d252e978a5a94baf99e4f00e36bfecb5 Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 10, Pp 431-438 (2020) diabetes antioxidants oxidative stress pathogenesis Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.4103/1995-7645.291036 2022-12-31T03:17:43Z Numerous studies have implicated oxidative stress in the development of complications of diabetes. During hyperglycemia, production of oxidant agents such as reactive oxygen species and reactive nitrogen species increases. This process, along with a decrease in the activity of antioxidant enzymes, induces oxidative stress in the body. This redox imbalance causes damage to vital biomolecules such as proteins, lipids and DNA and results in the generation of harmful products for the body. Mechanisms associated with the creation of oxidative stress conditions and subsequently complications of diabetes are explained through several pathways such as flux through the polyol pathway, intracellular production of advanced glycation end products precursors, protein kinase-C activation, and increased activities of the hexosamine pathway. On the other hand, the study of polymorphism in the antioxidant enzymes genes indicates that some of the gene polymorphisms reduce the antioxidant power of the enzymes. This article aims to review various studies to demonstrate the effect of oxidative stress on the pathogenesis of diabetes and the positive role of antioxidants on diabetic complications. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 13 10 431 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
diabetes antioxidants oxidative stress pathogenesis Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
diabetes antioxidants oxidative stress pathogenesis Arctic medicine. Tropical medicine RC955-962 Maryam Ghasemi-Dehnoo Hossein Amini-Khoei Zahra Lorigooini Mahmoud Rafieian-Kopaei Oxidative stress and antioxidants in diabetes mellitus |
topic_facet |
diabetes antioxidants oxidative stress pathogenesis Arctic medicine. Tropical medicine RC955-962 |
description |
Numerous studies have implicated oxidative stress in the development of complications of diabetes. During hyperglycemia, production of oxidant agents such as reactive oxygen species and reactive nitrogen species increases. This process, along with a decrease in the activity of antioxidant enzymes, induces oxidative stress in the body. This redox imbalance causes damage to vital biomolecules such as proteins, lipids and DNA and results in the generation of harmful products for the body. Mechanisms associated with the creation of oxidative stress conditions and subsequently complications of diabetes are explained through several pathways such as flux through the polyol pathway, intracellular production of advanced glycation end products precursors, protein kinase-C activation, and increased activities of the hexosamine pathway. On the other hand, the study of polymorphism in the antioxidant enzymes genes indicates that some of the gene polymorphisms reduce the antioxidant power of the enzymes. This article aims to review various studies to demonstrate the effect of oxidative stress on the pathogenesis of diabetes and the positive role of antioxidants on diabetic complications. |
format |
Article in Journal/Newspaper |
author |
Maryam Ghasemi-Dehnoo Hossein Amini-Khoei Zahra Lorigooini Mahmoud Rafieian-Kopaei |
author_facet |
Maryam Ghasemi-Dehnoo Hossein Amini-Khoei Zahra Lorigooini Mahmoud Rafieian-Kopaei |
author_sort |
Maryam Ghasemi-Dehnoo |
title |
Oxidative stress and antioxidants in diabetes mellitus |
title_short |
Oxidative stress and antioxidants in diabetes mellitus |
title_full |
Oxidative stress and antioxidants in diabetes mellitus |
title_fullStr |
Oxidative stress and antioxidants in diabetes mellitus |
title_full_unstemmed |
Oxidative stress and antioxidants in diabetes mellitus |
title_sort |
oxidative stress and antioxidants in diabetes mellitus |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/1995-7645.291036 https://doaj.org/article/d252e978a5a94baf99e4f00e36bfecb5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 10, Pp 431-438 (2020) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=10;spage=431;epage=438;aulast=Ghasemi-Dehnoo https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.291036 https://doaj.org/article/d252e978a5a94baf99e4f00e36bfecb5 |
op_doi |
https://doi.org/10.4103/1995-7645.291036 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
13 |
container_issue |
10 |
container_start_page |
431 |
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1766337122677030912 |