Population Genetic Polymorphism of Skeletal Muscle Strength Related Genes in Five Ethnic Minorities in North China
Musculoskeletal performance is a complex trait influenced by environmental and genetic factors, and it has different manifestations in different populations. Heilongjiang province, located in northern China, is a multi-ethnic region with human cultures dating back to the Paleolithic Age. The Daur, H...
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ftdoajarticles:oai:doaj.org/article:d1f39b42b4744ee78f9c66e0d030b2be 2023-05-15T16:09:17+02:00 Population Genetic Polymorphism of Skeletal Muscle Strength Related Genes in Five Ethnic Minorities in North China Bonan Dong Qiuyan Li Tingting Zhang Xiao Liang Mansha Jia Yansong Fu Jing Bai Songbin Fu 2021-10-01T00:00:00Z https://doi.org/10.3389/fgene.2021.756802 https://doaj.org/article/d1f39b42b4744ee78f9c66e0d030b2be EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fgene.2021.756802/full https://doaj.org/toc/1664-8021 1664-8021 doi:10.3389/fgene.2021.756802 https://doaj.org/article/d1f39b42b4744ee78f9c66e0d030b2be Frontiers in Genetics, Vol 12 (2021) skeletal muscle strength-related genes SNP ethnic groups phylogenetic relationship population genetics Genetics QH426-470 article 2021 ftdoajarticles https://doi.org/10.3389/fgene.2021.756802 2022-12-31T05:52:24Z Musculoskeletal performance is a complex trait influenced by environmental and genetic factors, and it has different manifestations in different populations. Heilongjiang province, located in northern China, is a multi-ethnic region with human cultures dating back to the Paleolithic Age. The Daur, Hezhen, Ewenki, Mongolian and Manchu ethnic groups in Heilongjiang province may have strong physical fitness to a certain extent. Based on the genetic characteristics of significant correlation between some important genes and skeletal muscle function, this study selected 23 SNPs of skeletal muscle strength-related genes and analyzed the distribution of these loci and genetic diversity in the five ethnic groups. Use Haploview (version 4.1) software to calculate the chi-square and the Hardy-Weinberg equilibrium to assess the difference between the two ethnic groups. Use R (version 4.0.2) software to perform principal component analysis of different ethnic groups. Use MEGA (version 7.0) software to construct the phylogenetic tree of different ethnic groups. Use POPGENE (version 1.32) software to calculate the heterozygosity and the FST values of 23 SNPs. Use Arlequin (version 3.5.2.2) software to analyze molecular variance (AMOVA) among 31 populations. The results showed that there was haplotype diversity of VDR, angiotensin-converting enzyme, ACTN3, EPO and IGF1 genes in the five ethnic groups, and there were genetic differences in the distribution of these genes in the five ethnic groups. Among them, the average gene heterozygosity (AVE_HET) of the 23 SNPs in the five populations was 0.398. The FST values of the 23 SNPs among the five ethnic groups varied from 0.0011 to 0.0137. According to the principal component analysis, the genetic distance of Daur, Mongolian and Ewenki is relatively close. According to the phylogenetic tree, the five ethnic groups are clustered together with the Asian population. These data will enrich existing genetic information of ethnic minorities. Article in Journal/Newspaper Ewenki Directory of Open Access Journals: DOAJ Articles Frontiers in Genetics 12 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
skeletal muscle strength-related genes SNP ethnic groups phylogenetic relationship population genetics Genetics QH426-470 |
spellingShingle |
skeletal muscle strength-related genes SNP ethnic groups phylogenetic relationship population genetics Genetics QH426-470 Bonan Dong Qiuyan Li Tingting Zhang Xiao Liang Mansha Jia Yansong Fu Jing Bai Songbin Fu Population Genetic Polymorphism of Skeletal Muscle Strength Related Genes in Five Ethnic Minorities in North China |
topic_facet |
skeletal muscle strength-related genes SNP ethnic groups phylogenetic relationship population genetics Genetics QH426-470 |
description |
Musculoskeletal performance is a complex trait influenced by environmental and genetic factors, and it has different manifestations in different populations. Heilongjiang province, located in northern China, is a multi-ethnic region with human cultures dating back to the Paleolithic Age. The Daur, Hezhen, Ewenki, Mongolian and Manchu ethnic groups in Heilongjiang province may have strong physical fitness to a certain extent. Based on the genetic characteristics of significant correlation between some important genes and skeletal muscle function, this study selected 23 SNPs of skeletal muscle strength-related genes and analyzed the distribution of these loci and genetic diversity in the five ethnic groups. Use Haploview (version 4.1) software to calculate the chi-square and the Hardy-Weinberg equilibrium to assess the difference between the two ethnic groups. Use R (version 4.0.2) software to perform principal component analysis of different ethnic groups. Use MEGA (version 7.0) software to construct the phylogenetic tree of different ethnic groups. Use POPGENE (version 1.32) software to calculate the heterozygosity and the FST values of 23 SNPs. Use Arlequin (version 3.5.2.2) software to analyze molecular variance (AMOVA) among 31 populations. The results showed that there was haplotype diversity of VDR, angiotensin-converting enzyme, ACTN3, EPO and IGF1 genes in the five ethnic groups, and there were genetic differences in the distribution of these genes in the five ethnic groups. Among them, the average gene heterozygosity (AVE_HET) of the 23 SNPs in the five populations was 0.398. The FST values of the 23 SNPs among the five ethnic groups varied from 0.0011 to 0.0137. According to the principal component analysis, the genetic distance of Daur, Mongolian and Ewenki is relatively close. According to the phylogenetic tree, the five ethnic groups are clustered together with the Asian population. These data will enrich existing genetic information of ethnic minorities. |
format |
Article in Journal/Newspaper |
author |
Bonan Dong Qiuyan Li Tingting Zhang Xiao Liang Mansha Jia Yansong Fu Jing Bai Songbin Fu |
author_facet |
Bonan Dong Qiuyan Li Tingting Zhang Xiao Liang Mansha Jia Yansong Fu Jing Bai Songbin Fu |
author_sort |
Bonan Dong |
title |
Population Genetic Polymorphism of Skeletal Muscle Strength Related Genes in Five Ethnic Minorities in North China |
title_short |
Population Genetic Polymorphism of Skeletal Muscle Strength Related Genes in Five Ethnic Minorities in North China |
title_full |
Population Genetic Polymorphism of Skeletal Muscle Strength Related Genes in Five Ethnic Minorities in North China |
title_fullStr |
Population Genetic Polymorphism of Skeletal Muscle Strength Related Genes in Five Ethnic Minorities in North China |
title_full_unstemmed |
Population Genetic Polymorphism of Skeletal Muscle Strength Related Genes in Five Ethnic Minorities in North China |
title_sort |
population genetic polymorphism of skeletal muscle strength related genes in five ethnic minorities in north china |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doi.org/10.3389/fgene.2021.756802 https://doaj.org/article/d1f39b42b4744ee78f9c66e0d030b2be |
genre |
Ewenki |
genre_facet |
Ewenki |
op_source |
Frontiers in Genetics, Vol 12 (2021) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fgene.2021.756802/full https://doaj.org/toc/1664-8021 1664-8021 doi:10.3389/fgene.2021.756802 https://doaj.org/article/d1f39b42b4744ee78f9c66e0d030b2be |
op_doi |
https://doi.org/10.3389/fgene.2021.756802 |
container_title |
Frontiers in Genetics |
container_volume |
12 |
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1766405188272259072 |