Cutaneous Leishmaniasis: An Overlooked Etiology of Midfacial Destructive Lesions.
BACKGROUND:Midline destructive lesions of the face (MDL) have a wide range of etiologies. Cutaneous Leishmaniasis (CL) is rarely reported as a possible cause. METHODS:Fifteen patients with solitary nasal lesions caused by CL were studied. The clinical data, biopsies/scrapings and PCR were collected/...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0004426 https://doaj.org/article/d1e4b183e5ac42ee8a050091bad119d0 |
id |
ftdoajarticles:oai:doaj.org/article:d1e4b183e5ac42ee8a050091bad119d0 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:d1e4b183e5ac42ee8a050091bad119d0 2023-05-15T15:09:42+02:00 Cutaneous Leishmaniasis: An Overlooked Etiology of Midfacial Destructive Lesions. Elie Alam Ossama Abbas Roger Moukarbel Ibrahim Khalifeh 2016-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004426 https://doaj.org/article/d1e4b183e5ac42ee8a050091bad119d0 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4749285?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004426 https://doaj.org/article/d1e4b183e5ac42ee8a050091bad119d0 PLoS Neglected Tropical Diseases, Vol 10, Iss 2, p e0004426 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004426 2022-12-31T06:04:21Z BACKGROUND:Midline destructive lesions of the face (MDL) have a wide range of etiologies. Cutaneous Leishmaniasis (CL) is rarely reported as a possible cause. METHODS:Fifteen patients with solitary nasal lesions caused by CL were studied. The clinical data, biopsies/scrapings and PCR were collected/performed. Ridley's Pattern (RP) and Parasitic Index (PI) were documented. RESULTS:Patients' age ranged from 1 to 60 years including 7 males and 8 females. The duration of the observed lesions ranged from 1 to 18 months. Clinically, the lesions showed 6 patterns varying from dermal erythematous papulonodular with no epidermal changes to destructive erythematous plaque with massive central hemorrhagic crust. The clinical impression ranged from neoplastic to inflammatory processes. RP varied among the cases [RP 3 (n = 6), RP 4 (n = 3), RP 5 (n = 6)]. All cases show low PI [PI 0 (n = 7), PI 1 (n = 6), PI 2 (n = 1), and PI 3 (n = 1)]. Higher PI was noted in the pediatric group [average age 24 years for PI 0-1 vs. 6.5 years for PI 2-3]. Molecular speciation showed Leishmania tropica (n = 13) and Leishmania major (n = 2). All the patients received Meglumine Antimoniate (Glucantine) injections and had initial cure defined as complete scarring and disappearance of inflammatory signs within 3 months. CONCLUSION:Leishmaniasis may cause MDL especially in endemic areas. PCR is instrumental in confirming the diagnosis. MDL caused by CL showed wide spectrum of clinical and microscopic presentation. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 2 e0004426 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Elie Alam Ossama Abbas Roger Moukarbel Ibrahim Khalifeh Cutaneous Leishmaniasis: An Overlooked Etiology of Midfacial Destructive Lesions. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Midline destructive lesions of the face (MDL) have a wide range of etiologies. Cutaneous Leishmaniasis (CL) is rarely reported as a possible cause. METHODS:Fifteen patients with solitary nasal lesions caused by CL were studied. The clinical data, biopsies/scrapings and PCR were collected/performed. Ridley's Pattern (RP) and Parasitic Index (PI) were documented. RESULTS:Patients' age ranged from 1 to 60 years including 7 males and 8 females. The duration of the observed lesions ranged from 1 to 18 months. Clinically, the lesions showed 6 patterns varying from dermal erythematous papulonodular with no epidermal changes to destructive erythematous plaque with massive central hemorrhagic crust. The clinical impression ranged from neoplastic to inflammatory processes. RP varied among the cases [RP 3 (n = 6), RP 4 (n = 3), RP 5 (n = 6)]. All cases show low PI [PI 0 (n = 7), PI 1 (n = 6), PI 2 (n = 1), and PI 3 (n = 1)]. Higher PI was noted in the pediatric group [average age 24 years for PI 0-1 vs. 6.5 years for PI 2-3]. Molecular speciation showed Leishmania tropica (n = 13) and Leishmania major (n = 2). All the patients received Meglumine Antimoniate (Glucantine) injections and had initial cure defined as complete scarring and disappearance of inflammatory signs within 3 months. CONCLUSION:Leishmaniasis may cause MDL especially in endemic areas. PCR is instrumental in confirming the diagnosis. MDL caused by CL showed wide spectrum of clinical and microscopic presentation. |
format |
Article in Journal/Newspaper |
author |
Elie Alam Ossama Abbas Roger Moukarbel Ibrahim Khalifeh |
author_facet |
Elie Alam Ossama Abbas Roger Moukarbel Ibrahim Khalifeh |
author_sort |
Elie Alam |
title |
Cutaneous Leishmaniasis: An Overlooked Etiology of Midfacial Destructive Lesions. |
title_short |
Cutaneous Leishmaniasis: An Overlooked Etiology of Midfacial Destructive Lesions. |
title_full |
Cutaneous Leishmaniasis: An Overlooked Etiology of Midfacial Destructive Lesions. |
title_fullStr |
Cutaneous Leishmaniasis: An Overlooked Etiology of Midfacial Destructive Lesions. |
title_full_unstemmed |
Cutaneous Leishmaniasis: An Overlooked Etiology of Midfacial Destructive Lesions. |
title_sort |
cutaneous leishmaniasis: an overlooked etiology of midfacial destructive lesions. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004426 https://doaj.org/article/d1e4b183e5ac42ee8a050091bad119d0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 2, p e0004426 (2016) |
op_relation |
http://europepmc.org/articles/PMC4749285?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004426 https://doaj.org/article/d1e4b183e5ac42ee8a050091bad119d0 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004426 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
10 |
container_issue |
2 |
container_start_page |
e0004426 |
_version_ |
1766340836804526080 |