Nodding syndrome: recent insights into etiology, pathophysiology, and treatment
Amos Deogratius Mwaka,1 Jerome Roy Semakula,2 Catherine Abbo,3 Richard Idro4 1Department of Medicine, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda; 2Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda; 3Department of...
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ftdoajarticles:oai:doaj.org/article:d1598c7acdec4dcabf062f3e349054a1 2023-05-15T15:12:26+02:00 Nodding syndrome: recent insights into etiology, pathophysiology, and treatment Mwaka AD Semakula JR Abbo C Idro R 2018-05-01T00:00:00Z https://doaj.org/article/d1598c7acdec4dcabf062f3e349054a1 EN eng Dove Medical Press https://www.dovepress.com/nodding-syndrome-recent-insights-into-etiology-pathophysiology-and-tre-peer-reviewed-article-RRTM https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/d1598c7acdec4dcabf062f3e349054a1 Research and Reports in Tropical Medicine, Vol Volume 9, Pp 89-93 (2018) Nodding Syndrome Epilepsy disorders Epilepsy Conspiracy theory Onchocerca volvulus Northern Uganda South Sudan Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles 2022-12-31T01:04:39Z Amos Deogratius Mwaka,1 Jerome Roy Semakula,2 Catherine Abbo,3 Richard Idro4 1Department of Medicine, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda; 2Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda; 3Department of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda; 4Department of Pediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda Abstract: Nodding syndrome is an enigmatic neuropsychiatric and epileptiform disorder associated with psychomotor, mental, and physical growth retardation. The disorder affects otherwise previously normal children aged 3–18 years, with a slight preponderance for the male child. Nodding syndrome has been described in rural regions of some low-income countries in sub-Saharan Africa including northern Uganda, South Sudan, and a mountainous region of southern Tanzania. The cause of the disorder has hitherto eluded scientists. Neuroimaging studies show involvement of the nervous system with associated severe cortical atrophy in the affected children. The affected communities have generated a number of perceived causes including some conspiracy theories related to intentional poisoning of water sources and foods, and causes related to fumes and chemicals from ammunitions used during civil wars in the affected regions. From biomedical perspectives, the treatment of the affected children is geared towards symptoms control and rehabilitation. There is evidence that seizures and behavioral problems including wandering and episodes of aggressions are controllable with anticonvulsants, especially sodium valproate and antipsychotics. No treatments have proven effective in reversing the course of the disorder, and cure remains a distant goal. Community members have used indigenous medicines, cleansing rituals, and prayer interventions, but have not perceived any reasonable improvements. A randomized controlled clinical trial is ongoing in northern ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
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English |
topic |
Nodding Syndrome Epilepsy disorders Epilepsy Conspiracy theory Onchocerca volvulus Northern Uganda South Sudan Arctic medicine. Tropical medicine RC955-962 |
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Nodding Syndrome Epilepsy disorders Epilepsy Conspiracy theory Onchocerca volvulus Northern Uganda South Sudan Arctic medicine. Tropical medicine RC955-962 Mwaka AD Semakula JR Abbo C Idro R Nodding syndrome: recent insights into etiology, pathophysiology, and treatment |
topic_facet |
Nodding Syndrome Epilepsy disorders Epilepsy Conspiracy theory Onchocerca volvulus Northern Uganda South Sudan Arctic medicine. Tropical medicine RC955-962 |
description |
Amos Deogratius Mwaka,1 Jerome Roy Semakula,2 Catherine Abbo,3 Richard Idro4 1Department of Medicine, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda; 2Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda; 3Department of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda; 4Department of Pediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda Abstract: Nodding syndrome is an enigmatic neuropsychiatric and epileptiform disorder associated with psychomotor, mental, and physical growth retardation. The disorder affects otherwise previously normal children aged 3–18 years, with a slight preponderance for the male child. Nodding syndrome has been described in rural regions of some low-income countries in sub-Saharan Africa including northern Uganda, South Sudan, and a mountainous region of southern Tanzania. The cause of the disorder has hitherto eluded scientists. Neuroimaging studies show involvement of the nervous system with associated severe cortical atrophy in the affected children. The affected communities have generated a number of perceived causes including some conspiracy theories related to intentional poisoning of water sources and foods, and causes related to fumes and chemicals from ammunitions used during civil wars in the affected regions. From biomedical perspectives, the treatment of the affected children is geared towards symptoms control and rehabilitation. There is evidence that seizures and behavioral problems including wandering and episodes of aggressions are controllable with anticonvulsants, especially sodium valproate and antipsychotics. No treatments have proven effective in reversing the course of the disorder, and cure remains a distant goal. Community members have used indigenous medicines, cleansing rituals, and prayer interventions, but have not perceived any reasonable improvements. A randomized controlled clinical trial is ongoing in northern ... |
format |
Article in Journal/Newspaper |
author |
Mwaka AD Semakula JR Abbo C Idro R |
author_facet |
Mwaka AD Semakula JR Abbo C Idro R |
author_sort |
Mwaka AD |
title |
Nodding syndrome: recent insights into etiology, pathophysiology, and treatment |
title_short |
Nodding syndrome: recent insights into etiology, pathophysiology, and treatment |
title_full |
Nodding syndrome: recent insights into etiology, pathophysiology, and treatment |
title_fullStr |
Nodding syndrome: recent insights into etiology, pathophysiology, and treatment |
title_full_unstemmed |
Nodding syndrome: recent insights into etiology, pathophysiology, and treatment |
title_sort |
nodding syndrome: recent insights into etiology, pathophysiology, and treatment |
publisher |
Dove Medical Press |
publishDate |
2018 |
url |
https://doaj.org/article/d1598c7acdec4dcabf062f3e349054a1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Research and Reports in Tropical Medicine, Vol Volume 9, Pp 89-93 (2018) |
op_relation |
https://www.dovepress.com/nodding-syndrome-recent-insights-into-etiology-pathophysiology-and-tre-peer-reviewed-article-RRTM https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/d1598c7acdec4dcabf062f3e349054a1 |
_version_ |
1766343114633510912 |