Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children
Abstract Background As malaria control efforts intensify, it is critical to monitor trends in disease burden and measure the impact of interventions. A key surveillance indicator is the incidence of malaria. Yet measurement of incidence is challenging. The slide positivity rate (SPR) has been used a...
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ftdoajarticles:oai:doaj.org/article:d13a3222e2af42aca7507d6e373a85d5 2023-05-15T15:18:05+02:00 Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children Kamya Moses R Francis Damon Njama-Meya Denise Bukirwa Hasifa Jensen Trevor P Rosenthal Philip J Dorsey Grant 2009-09-01T00:00:00Z https://doi.org/10.1186/1475-2875-8-213 https://doaj.org/article/d13a3222e2af42aca7507d6e373a85d5 EN eng BMC http://www.malariajournal.com/content/8/1/213 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-213 1475-2875 https://doaj.org/article/d13a3222e2af42aca7507d6e373a85d5 Malaria Journal, Vol 8, Iss 1, p 213 (2009) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1186/1475-2875-8-213 2022-12-31T12:31:04Z Abstract Background As malaria control efforts intensify, it is critical to monitor trends in disease burden and measure the impact of interventions. A key surveillance indicator is the incidence of malaria. Yet measurement of incidence is challenging. The slide positivity rate (SPR) has been used as a surrogate measure of malaria incidence, but limited data exist on the relationship between SPR and the incidence of malaria. Methods A cohort of 690 children aged 1-10 years at enrollment were followed for all their health care needs over a four-year period in Kampala, Uganda. All children with fever underwent laboratory testing, allowing us to measure the incidence of malaria and non-malaria fevers. A formula was derived to estimate relative changes in the incidence of malaria (rΔIm) based on changes in the SPR and the assumption that the incidence of non-malaria fevers was consistent over time. Observed and estimated values of rΔIm were compared over two, six, and 12 month time intervals after restricting the analysis to children contributing observation time between the ages of 4-10 years to control for aging of the cohort. Results Over the four-year observation period the incidence of malaria declined significantly from 0.93 episodes per person-year in 2005 to 0.39 episodes per person-year in 2008 (p < 0.0001) and the incidence of non-malaria fevers declined significantly from 2.31 episodes per person-year in 2005 to 1.31 episodes per person-year in 2008 (p < 0.0001). Younger age was associated with a significantly greater incidence of malaria and the incidence of malaria was significantly higher during seasonal peaks occurring each January-February and May-June. Changes in SPR produced reasonably accurate estimates of rΔIm over all time intervals. The average absolute difference in observed and estimated values of rΔIm was lower for six-month intervals (0.13) than it was for two-month (0.21) or 12 month intervals (0.21). Conclusion Changes in SPR provided a useful estimate of changes in the incidence of ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 8 1 213 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kamya Moses R Francis Damon Njama-Meya Denise Bukirwa Hasifa Jensen Trevor P Rosenthal Philip J Dorsey Grant Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background As malaria control efforts intensify, it is critical to monitor trends in disease burden and measure the impact of interventions. A key surveillance indicator is the incidence of malaria. Yet measurement of incidence is challenging. The slide positivity rate (SPR) has been used as a surrogate measure of malaria incidence, but limited data exist on the relationship between SPR and the incidence of malaria. Methods A cohort of 690 children aged 1-10 years at enrollment were followed for all their health care needs over a four-year period in Kampala, Uganda. All children with fever underwent laboratory testing, allowing us to measure the incidence of malaria and non-malaria fevers. A formula was derived to estimate relative changes in the incidence of malaria (rΔIm) based on changes in the SPR and the assumption that the incidence of non-malaria fevers was consistent over time. Observed and estimated values of rΔIm were compared over two, six, and 12 month time intervals after restricting the analysis to children contributing observation time between the ages of 4-10 years to control for aging of the cohort. Results Over the four-year observation period the incidence of malaria declined significantly from 0.93 episodes per person-year in 2005 to 0.39 episodes per person-year in 2008 (p < 0.0001) and the incidence of non-malaria fevers declined significantly from 2.31 episodes per person-year in 2005 to 1.31 episodes per person-year in 2008 (p < 0.0001). Younger age was associated with a significantly greater incidence of malaria and the incidence of malaria was significantly higher during seasonal peaks occurring each January-February and May-June. Changes in SPR produced reasonably accurate estimates of rΔIm over all time intervals. The average absolute difference in observed and estimated values of rΔIm was lower for six-month intervals (0.13) than it was for two-month (0.21) or 12 month intervals (0.21). Conclusion Changes in SPR provided a useful estimate of changes in the incidence of ... |
format |
Article in Journal/Newspaper |
author |
Kamya Moses R Francis Damon Njama-Meya Denise Bukirwa Hasifa Jensen Trevor P Rosenthal Philip J Dorsey Grant |
author_facet |
Kamya Moses R Francis Damon Njama-Meya Denise Bukirwa Hasifa Jensen Trevor P Rosenthal Philip J Dorsey Grant |
author_sort |
Kamya Moses R |
title |
Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children |
title_short |
Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children |
title_full |
Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children |
title_fullStr |
Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children |
title_full_unstemmed |
Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children |
title_sort |
use of the slide positivity rate to estimate changes in malaria incidence in a cohort of ugandan children |
publisher |
BMC |
publishDate |
2009 |
url |
https://doi.org/10.1186/1475-2875-8-213 https://doaj.org/article/d13a3222e2af42aca7507d6e373a85d5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 8, Iss 1, p 213 (2009) |
op_relation |
http://www.malariajournal.com/content/8/1/213 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-213 1475-2875 https://doaj.org/article/d13a3222e2af42aca7507d6e373a85d5 |
op_doi |
https://doi.org/10.1186/1475-2875-8-213 |
container_title |
Malaria Journal |
container_volume |
8 |
container_issue |
1 |
container_start_page |
213 |
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1766348316055961600 |