The prevalence of the hepatitis C virus among the conditionally healthy population of the Russian Federation

• Published in: Journal Infectology
• Main Authors: N. V. Soboleva, A. A. Karlsen, T. V. Kozhanova, V. S. Kichatova, V. V. Klushkina, O. V. Isaeva, M. E. Ignatieva, V. V. Romanenko, N. D. Oorzhak, E. Yu. Malinnikova, K. K. Kuregyan, M. I. Mikhailov
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: Journal Infectology 2017
• Subjects: вирус гепатита с (вгс); анти- вгс; рнк вгс; возрастные когорты; популяционные исследования; Infectious and parasitic diseases; RC109-216; Sakha; Sakha Republic; Yakutia
• Online Access: https://doi.org/10.22625/2072-6732-2017-9-2-56-64; https://doaj.org/article/d1377022f8b544bd8cf7a661a92ae26d

Aim. To determine the prevalence of hepatitis C virus (HCV) in different age groups of the conditionally healthy population of Russia.Materials and methods. Total 4764 serum samples from a conditionally healthy population of five regions of Russia (Moscow, Rostov, Sverdlovsk regions, Tyva Republic, and Sakha Republic (Yakutia) were tested. The study included persons of 10 age groups: < 1 year, 1–4 years, 5–9 years, 10–14 years, 15–19 years, 20–29 years, 30–39 years, 40–49 years, 50–59 years old, ≥ 60 years. Anti-HCV was determined in ELISA with commercial test systems. Anti-HCV positive samples were tested for HCV RNA by RT-PCR. The genotype of HCV was determined based on the analysis of the nucleotide sequences of the core and NS5B regions of the viral genome.Results. The overall prevalence of anti-HCV in 5 regions of Russia was 2,6% (126/4764), and the proportion of people with HCV RNA was 1,1% (50/4764). The highest anti-HCV positivity rate was observed in Tyva and Yakutia (3,3% in both regions), in other regions its prevalence varied from 1,7% (Moscow region) to 3,0% (Sverdlovsk region). The highest frequency of HCV RNA detection was observerd in Tyva Republic and Rostov region (1.3% in both regions). No positive for HCV RNA cases was detected among persons aged 0–19 years in any region, except for Tyva Republic (1,0% (1/98) in age group 15–19 years). Peak positivity rates of HCV RNA were detected in the age groups 20–29 years and 30–39 years in the Rostov Region (3,9% and 3,0%, respectively); in Yakutia – in the group of 30–39 years (3,7%), in Tyva – in the group of 40–49 years (3,6%), in the Moscow region – in the groups of 20–29 and 30–39 years (2,9% and 2,5%, respectively).Conclusion. The results obtained indicate a high degree of HCV infection in virtually all age groups in the interval from 20 years to ≥60 years. Specific age cohorts that might benefit from inclusion in regional HCV screening programs were identified in each region.