The influence of HIV and schistosomiasis on renal function: a cross-sectional study among children at a hospital in Tanzania.
Schistosomiasis and HIV are both associated with kidney disease. Prevalence and factors associated with abnormal renal function among HIV-infected children in Africa compared to uninfected controls have not been well described in a schistosomiasis endemic area.This cross-sectional study was conducte...
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ftdoajarticles:oai:doaj.org/article:d1312b70dd244abca5bf70166b48fe5c 2023-05-15T15:09:22+02:00 The influence of HIV and schistosomiasis on renal function: a cross-sectional study among children at a hospital in Tanzania. Neema M Kayange Luke R Smart Jennifer A Downs Mwanaisha Maskini Daniel W Fitzgerald Robert N Peck 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003472 https://doaj.org/article/d1312b70dd244abca5bf70166b48fe5c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4303314?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003472 https://doaj.org/article/d1312b70dd244abca5bf70166b48fe5c PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e0003472 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003472 2022-12-30T22:56:43Z Schistosomiasis and HIV are both associated with kidney disease. Prevalence and factors associated with abnormal renal function among HIV-infected children in Africa compared to uninfected controls have not been well described in a schistosomiasis endemic area.This cross-sectional study was conducted at the Sekou Toure Regional Hospital HIV clinic in Mwanza, Tanzania. A total of 122 HIV-infected children and 122 HIV-uninfected siblings were consecutively enrolled. Fresh urine was obtained for measurement of albuminuria and Schistosoma circulating cathodic antigen. Blood was collected for measurement of serum creatinine. Estimated glomerular filtration rate (eGFR) was calculated using the modified Schwartz equation. Renal dysfunction was defined operationally as eGFR<60 mL/min/1.73 m2 and/or albuminuria>20 mg/L in a single sample. Among 122 HIV-infected children, 61/122 (50.0%) met our criteria for renal dysfunction: 54/122 (44.3%) had albuminuria>20 mg/L and 9/122 (7.4%) had eGFR<60. Among 122 HIV-uninfected children, 51/122 (41.8%) met our criteria for renal dysfunction: 48/122 (39.3%) had albuminuria>20 mg/L and 6/122 (4.9%) had eGFR<60. Schistosomiasis was the only factor significantly associated with renal dysfunction by multivariable logistic regression (OR = 2.51, 95% CI 1.46-4.31, p = 0.001).A high prevalence of renal dysfunction exists among both HIV-infected Tanzanian children and their HIV-uninfected siblings. Schistosomiasis was strongly associated with renal dysfunction. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 1 e0003472 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Neema M Kayange Luke R Smart Jennifer A Downs Mwanaisha Maskini Daniel W Fitzgerald Robert N Peck The influence of HIV and schistosomiasis on renal function: a cross-sectional study among children at a hospital in Tanzania. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Schistosomiasis and HIV are both associated with kidney disease. Prevalence and factors associated with abnormal renal function among HIV-infected children in Africa compared to uninfected controls have not been well described in a schistosomiasis endemic area.This cross-sectional study was conducted at the Sekou Toure Regional Hospital HIV clinic in Mwanza, Tanzania. A total of 122 HIV-infected children and 122 HIV-uninfected siblings were consecutively enrolled. Fresh urine was obtained for measurement of albuminuria and Schistosoma circulating cathodic antigen. Blood was collected for measurement of serum creatinine. Estimated glomerular filtration rate (eGFR) was calculated using the modified Schwartz equation. Renal dysfunction was defined operationally as eGFR<60 mL/min/1.73 m2 and/or albuminuria>20 mg/L in a single sample. Among 122 HIV-infected children, 61/122 (50.0%) met our criteria for renal dysfunction: 54/122 (44.3%) had albuminuria>20 mg/L and 9/122 (7.4%) had eGFR<60. Among 122 HIV-uninfected children, 51/122 (41.8%) met our criteria for renal dysfunction: 48/122 (39.3%) had albuminuria>20 mg/L and 6/122 (4.9%) had eGFR<60. Schistosomiasis was the only factor significantly associated with renal dysfunction by multivariable logistic regression (OR = 2.51, 95% CI 1.46-4.31, p = 0.001).A high prevalence of renal dysfunction exists among both HIV-infected Tanzanian children and their HIV-uninfected siblings. Schistosomiasis was strongly associated with renal dysfunction. |
format |
Article in Journal/Newspaper |
author |
Neema M Kayange Luke R Smart Jennifer A Downs Mwanaisha Maskini Daniel W Fitzgerald Robert N Peck |
author_facet |
Neema M Kayange Luke R Smart Jennifer A Downs Mwanaisha Maskini Daniel W Fitzgerald Robert N Peck |
author_sort |
Neema M Kayange |
title |
The influence of HIV and schistosomiasis on renal function: a cross-sectional study among children at a hospital in Tanzania. |
title_short |
The influence of HIV and schistosomiasis on renal function: a cross-sectional study among children at a hospital in Tanzania. |
title_full |
The influence of HIV and schistosomiasis on renal function: a cross-sectional study among children at a hospital in Tanzania. |
title_fullStr |
The influence of HIV and schistosomiasis on renal function: a cross-sectional study among children at a hospital in Tanzania. |
title_full_unstemmed |
The influence of HIV and schistosomiasis on renal function: a cross-sectional study among children at a hospital in Tanzania. |
title_sort |
influence of hiv and schistosomiasis on renal function: a cross-sectional study among children at a hospital in tanzania. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003472 https://doaj.org/article/d1312b70dd244abca5bf70166b48fe5c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e0003472 (2015) |
op_relation |
http://europepmc.org/articles/PMC4303314?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003472 https://doaj.org/article/d1312b70dd244abca5bf70166b48fe5c |
op_doi |
https://doi.org/10.1371/journal.pntd.0003472 |
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PLOS Neglected Tropical Diseases |
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9 |
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1 |
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e0003472 |
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