Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015.
BACKGROUND:Leptospirosis is a worldwide zoonotic bacterial disease caused by infection with leptospires. Leptospirosis in humans and livestock is an endemic and epidemic disease in Thailand. Livestock may act as reservoirs for leptospires and source for human infection. METHODOLOGY/PRINCIPAL FINDING...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0005228 https://doaj.org/article/d0ff660f5ba84800a52585648829ef6e |
id |
ftdoajarticles:oai:doaj.org/article:d0ff660f5ba84800a52585648829ef6e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:d0ff660f5ba84800a52585648829ef6e 2023-05-15T15:13:07+02:00 Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015. Sudarat Chadsuthi Dominique J Bicout Anuwat Wiratsudakul Duangjai Suwancharoen Wimol Petkanchanapong Charin Modchang Wannapong Triampo Parntep Ratanakorn Karine Chalvet-Monfray 2017-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005228 https://doaj.org/article/d0ff660f5ba84800a52585648829ef6e EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5325611?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005228 https://doaj.org/article/d0ff660f5ba84800a52585648829ef6e PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005228 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005228 2022-12-31T08:43:03Z BACKGROUND:Leptospirosis is a worldwide zoonotic bacterial disease caused by infection with leptospires. Leptospirosis in humans and livestock is an endemic and epidemic disease in Thailand. Livestock may act as reservoirs for leptospires and source for human infection. METHODOLOGY/PRINCIPAL FINDINGS:Data on leptospirosis infection in humans and livestock (Buffaloes, Cattle, and Pigs) species during 2010 to 2015 were analyzed. Serum samples were examined using Microscopic Agglutination Test (MAT) to identify antibodies against Leptospira serovars using a cut-off titer ≥ 1:100. The seroprevalence was 23.7% in humans, 24.8% in buffaloes, 28.1% in cattle, and 11.3% in pigs. Region specific prevalence among humans and livestock was found in a wide range. The most predominant serovars were Shermani, followed by Bratislava, Panama, and Sejroe in human, Shermani, Ranarum, and Tarassovi in buffaloes, and Shermani and Ranarum in cattle and pigs. Equally highest MAT titers against multiple serovars per one sample were found mainly in buffaloes and cattle showing equally titers against Ranarum and Shermani. The correlations of distribution of serovars across Thailand's regions were found to be similar in pattern for cattle but not for buffaloes. In humans, the serovar distribution in the south differed from other regions. By logistic regression, the results indicated that livestock is more susceptible to infection by serovar Shermani when compared to humans. CONCLUSIONS/SIGNIFICANCE:This study gives a detailed picture of the predominance of Leptospira serovars in relation to region, humans and typical livestock. The broad spatial distribution of seroprevalence was analyzed across and within species as well as regions in Thailand. Our finding may guide public health policy makers to implement appropriate control measures and help to reduce the impact of leptospirosis in Thailand. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 2 e0005228 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sudarat Chadsuthi Dominique J Bicout Anuwat Wiratsudakul Duangjai Suwancharoen Wimol Petkanchanapong Charin Modchang Wannapong Triampo Parntep Ratanakorn Karine Chalvet-Monfray Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Leptospirosis is a worldwide zoonotic bacterial disease caused by infection with leptospires. Leptospirosis in humans and livestock is an endemic and epidemic disease in Thailand. Livestock may act as reservoirs for leptospires and source for human infection. METHODOLOGY/PRINCIPAL FINDINGS:Data on leptospirosis infection in humans and livestock (Buffaloes, Cattle, and Pigs) species during 2010 to 2015 were analyzed. Serum samples were examined using Microscopic Agglutination Test (MAT) to identify antibodies against Leptospira serovars using a cut-off titer ≥ 1:100. The seroprevalence was 23.7% in humans, 24.8% in buffaloes, 28.1% in cattle, and 11.3% in pigs. Region specific prevalence among humans and livestock was found in a wide range. The most predominant serovars were Shermani, followed by Bratislava, Panama, and Sejroe in human, Shermani, Ranarum, and Tarassovi in buffaloes, and Shermani and Ranarum in cattle and pigs. Equally highest MAT titers against multiple serovars per one sample were found mainly in buffaloes and cattle showing equally titers against Ranarum and Shermani. The correlations of distribution of serovars across Thailand's regions were found to be similar in pattern for cattle but not for buffaloes. In humans, the serovar distribution in the south differed from other regions. By logistic regression, the results indicated that livestock is more susceptible to infection by serovar Shermani when compared to humans. CONCLUSIONS/SIGNIFICANCE:This study gives a detailed picture of the predominance of Leptospira serovars in relation to region, humans and typical livestock. The broad spatial distribution of seroprevalence was analyzed across and within species as well as regions in Thailand. Our finding may guide public health policy makers to implement appropriate control measures and help to reduce the impact of leptospirosis in Thailand. |
format |
Article in Journal/Newspaper |
author |
Sudarat Chadsuthi Dominique J Bicout Anuwat Wiratsudakul Duangjai Suwancharoen Wimol Petkanchanapong Charin Modchang Wannapong Triampo Parntep Ratanakorn Karine Chalvet-Monfray |
author_facet |
Sudarat Chadsuthi Dominique J Bicout Anuwat Wiratsudakul Duangjai Suwancharoen Wimol Petkanchanapong Charin Modchang Wannapong Triampo Parntep Ratanakorn Karine Chalvet-Monfray |
author_sort |
Sudarat Chadsuthi |
title |
Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015. |
title_short |
Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015. |
title_full |
Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015. |
title_fullStr |
Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015. |
title_full_unstemmed |
Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015. |
title_sort |
investigation on predominant leptospira serovars and its distribution in humans and livestock in thailand, 2010-2015. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005228 https://doaj.org/article/d0ff660f5ba84800a52585648829ef6e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005228 (2017) |
op_relation |
http://europepmc.org/articles/PMC5325611?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005228 https://doaj.org/article/d0ff660f5ba84800a52585648829ef6e |
op_doi |
https://doi.org/10.1371/journal.pntd.0005228 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
2 |
container_start_page |
e0005228 |
_version_ |
1766343712621723648 |