Differential regional immune response in Chagas disease.
Following infection, lymphocytes expand exponentially and differentiate into effector cells to control infection and coordinate the multiple effector arms of the immune response. Soon after this expansion, the majority of antigen-specific lymphocytes die, thus keeping homeostasis, and a small pool o...
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ftdoajarticles:oai:doaj.org/article:d074b4a81d1449e3a10034ed8f15229a 2023-05-15T15:09:20+02:00 Differential regional immune response in Chagas disease. Juliana de Meis Alexandre Morrot Désio Aurélio Farias-de-Oliveira Déa Maria Serra Villa-Verde Wilson Savino 2009-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000417 https://doaj.org/article/d074b4a81d1449e3a10034ed8f15229a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2700264?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0000417 https://doaj.org/article/d074b4a81d1449e3a10034ed8f15229a PLoS Neglected Tropical Diseases, Vol 3, Iss 7, p e417 (2009) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2009 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000417 2022-12-31T13:04:06Z Following infection, lymphocytes expand exponentially and differentiate into effector cells to control infection and coordinate the multiple effector arms of the immune response. Soon after this expansion, the majority of antigen-specific lymphocytes die, thus keeping homeostasis, and a small pool of memory cells develops, providing long-term immunity to subsequent reinfection. The extent of infection and rate of pathogen clearance are thought to determine both the magnitude of cell expansion and the homeostatic contraction to a stable number of memory cells. This straight correlation between the kinetics of T cell response and the dynamics of lymphoid tissue cell numbers is a constant feature in acute infections yielded by pathogens that are cleared during the course of response. However, the regional dynamics of the immune response mounted against pathogens that are able to establish a persistent infection remain poorly understood. Herein we discuss the differential lymphocyte dynamics in distinct central and peripheral lymphoid organs following acute infection by Trypanosoma cruzi, the causative agent of Chagas disease. While the thymus and mesenteric lymph nodes undergo a severe atrophy with massive lymphocyte depletion, the spleen and subcutaneous lymph nodes expand due to T and B cell activation/proliferation. These events are regulated by cytokines, as well as parasite-derived moieties. In this regard, identifying the molecular mechanisms underlying regional lymphocyte dynamics secondary to T. cruzi infection may hopefully contribute to the design of novel immune intervention strategies to control pathology in this infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 3 7 e417 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Juliana de Meis Alexandre Morrot Désio Aurélio Farias-de-Oliveira Déa Maria Serra Villa-Verde Wilson Savino Differential regional immune response in Chagas disease. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Following infection, lymphocytes expand exponentially and differentiate into effector cells to control infection and coordinate the multiple effector arms of the immune response. Soon after this expansion, the majority of antigen-specific lymphocytes die, thus keeping homeostasis, and a small pool of memory cells develops, providing long-term immunity to subsequent reinfection. The extent of infection and rate of pathogen clearance are thought to determine both the magnitude of cell expansion and the homeostatic contraction to a stable number of memory cells. This straight correlation between the kinetics of T cell response and the dynamics of lymphoid tissue cell numbers is a constant feature in acute infections yielded by pathogens that are cleared during the course of response. However, the regional dynamics of the immune response mounted against pathogens that are able to establish a persistent infection remain poorly understood. Herein we discuss the differential lymphocyte dynamics in distinct central and peripheral lymphoid organs following acute infection by Trypanosoma cruzi, the causative agent of Chagas disease. While the thymus and mesenteric lymph nodes undergo a severe atrophy with massive lymphocyte depletion, the spleen and subcutaneous lymph nodes expand due to T and B cell activation/proliferation. These events are regulated by cytokines, as well as parasite-derived moieties. In this regard, identifying the molecular mechanisms underlying regional lymphocyte dynamics secondary to T. cruzi infection may hopefully contribute to the design of novel immune intervention strategies to control pathology in this infection. |
format |
Article in Journal/Newspaper |
author |
Juliana de Meis Alexandre Morrot Désio Aurélio Farias-de-Oliveira Déa Maria Serra Villa-Verde Wilson Savino |
author_facet |
Juliana de Meis Alexandre Morrot Désio Aurélio Farias-de-Oliveira Déa Maria Serra Villa-Verde Wilson Savino |
author_sort |
Juliana de Meis |
title |
Differential regional immune response in Chagas disease. |
title_short |
Differential regional immune response in Chagas disease. |
title_full |
Differential regional immune response in Chagas disease. |
title_fullStr |
Differential regional immune response in Chagas disease. |
title_full_unstemmed |
Differential regional immune response in Chagas disease. |
title_sort |
differential regional immune response in chagas disease. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2009 |
url |
https://doi.org/10.1371/journal.pntd.0000417 https://doaj.org/article/d074b4a81d1449e3a10034ed8f15229a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 3, Iss 7, p e417 (2009) |
op_relation |
http://europepmc.org/articles/PMC2700264?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0000417 https://doaj.org/article/d074b4a81d1449e3a10034ed8f15229a |
op_doi |
https://doi.org/10.1371/journal.pntd.0000417 |
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PLoS Neglected Tropical Diseases |
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3 |
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7 |
container_start_page |
e417 |
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