Trends in research involving human beings in Brazil
Developing countries have experienced a dramatic increase in the number of clinical studies in the last decades. The aim of this study was to describe 1) the number of clinical trials submitted to the Brazilian Health Surveillance Agency (Agência Nacional de Vigilância Sanitária, Anvisa) from 2007 t...
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ftdoajarticles:oai:doaj.org/article:d0608d167d6e4f778b08cc29404ae3d5 2023-05-15T15:14:55+02:00 Trends in research involving human beings in Brazil Ricardo Eccard da Silva Maria Rita Carvalho Novaes Elza Martínez Pastor Elena Barragan Angélica Amorim Amato 2015-02-01T00:00:00Z https://doaj.org/article/d0608d167d6e4f778b08cc29404ae3d5 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892015000200008&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 https://doaj.org/article/d0608d167d6e4f778b08cc29404ae3d5 Revista Panamericana de Salud Pública, Vol 37, Iss 2, Pp 118-124 (2015) Enfermedades desatendidas ensayos clínicos como asunto Brasil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles 2022-12-31T16:11:59Z Developing countries have experienced a dramatic increase in the number of clinical studies in the last decades. The aim of this study was to describe 1) the number of clinical trials submitted to the Brazilian Health Surveillance Agency (Agência Nacional de Vigilância Sanitária, Anvisa) from 2007 to 2012 and the number of human-subject research projects approved by research ethics committees (RECs) and the National Research Ethics Committee (Comissão Nacional de Ética em Pesquisa, CONEP) in Brazil from 2007 to 2011 and 2) the diseases most frequently studied in Brazilian states in clinical trials approved in the country from 2009 to 2012, based on information from an Anvisa databank. Two databases were used: 1) the National Information System on Research Ethics Involving Human Beings (Sistema Nacional de Informação Sobre Ética em Pesquisa envolvendo Seres Humanos, SISNEP) and 2) Anvisa's Clinical Research Control System (Sistema de Controle de Pesquisa Clínica, SCPC). Data from the SCPC indicated an increase of 32.7% in the number of clinical trials submitted to Anvisa, and data from the SISNEP showed an increase of 69.9% in those approved by RECs and CONEP (from 18 160 in 2007 to 30 860 in 2011). Type 2 diabetes (26.0%) and breast cancer (20.5%)-related to the main causes of mortality in Brazil-were the two most frequently studied diseases. The so-called “neglected diseases,” such as dengue fever, were among the least studied diseases in approved clinical trials, despite their significant impact on social, economic, and health indicators in Brazil. Overall, the data indicated 1) a clear trend toward more research involving human beings in Brazil, 2) good correspondence between diseases most studied in clinical trials approved by Anvisa and the main causes of death in Brazil, and 3) a low level of attention to neglected diseases, an issue that should be considered in setting future research priorities, given their socioeconomic and health effects. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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English Spanish Portuguese |
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Enfermedades desatendidas ensayos clínicos como asunto Brasil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Enfermedades desatendidas ensayos clínicos como asunto Brasil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ricardo Eccard da Silva Maria Rita Carvalho Novaes Elza Martínez Pastor Elena Barragan Angélica Amorim Amato Trends in research involving human beings in Brazil |
topic_facet |
Enfermedades desatendidas ensayos clínicos como asunto Brasil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Developing countries have experienced a dramatic increase in the number of clinical studies in the last decades. The aim of this study was to describe 1) the number of clinical trials submitted to the Brazilian Health Surveillance Agency (Agência Nacional de Vigilância Sanitária, Anvisa) from 2007 to 2012 and the number of human-subject research projects approved by research ethics committees (RECs) and the National Research Ethics Committee (Comissão Nacional de Ética em Pesquisa, CONEP) in Brazil from 2007 to 2011 and 2) the diseases most frequently studied in Brazilian states in clinical trials approved in the country from 2009 to 2012, based on information from an Anvisa databank. Two databases were used: 1) the National Information System on Research Ethics Involving Human Beings (Sistema Nacional de Informação Sobre Ética em Pesquisa envolvendo Seres Humanos, SISNEP) and 2) Anvisa's Clinical Research Control System (Sistema de Controle de Pesquisa Clínica, SCPC). Data from the SCPC indicated an increase of 32.7% in the number of clinical trials submitted to Anvisa, and data from the SISNEP showed an increase of 69.9% in those approved by RECs and CONEP (from 18 160 in 2007 to 30 860 in 2011). Type 2 diabetes (26.0%) and breast cancer (20.5%)-related to the main causes of mortality in Brazil-were the two most frequently studied diseases. The so-called “neglected diseases,” such as dengue fever, were among the least studied diseases in approved clinical trials, despite their significant impact on social, economic, and health indicators in Brazil. Overall, the data indicated 1) a clear trend toward more research involving human beings in Brazil, 2) good correspondence between diseases most studied in clinical trials approved by Anvisa and the main causes of death in Brazil, and 3) a low level of attention to neglected diseases, an issue that should be considered in setting future research priorities, given their socioeconomic and health effects. |
format |
Article in Journal/Newspaper |
author |
Ricardo Eccard da Silva Maria Rita Carvalho Novaes Elza Martínez Pastor Elena Barragan Angélica Amorim Amato |
author_facet |
Ricardo Eccard da Silva Maria Rita Carvalho Novaes Elza Martínez Pastor Elena Barragan Angélica Amorim Amato |
author_sort |
Ricardo Eccard da Silva |
title |
Trends in research involving human beings in Brazil |
title_short |
Trends in research involving human beings in Brazil |
title_full |
Trends in research involving human beings in Brazil |
title_fullStr |
Trends in research involving human beings in Brazil |
title_full_unstemmed |
Trends in research involving human beings in Brazil |
title_sort |
trends in research involving human beings in brazil |
publisher |
Pan American Health Organization |
publishDate |
2015 |
url |
https://doaj.org/article/d0608d167d6e4f778b08cc29404ae3d5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 37, Iss 2, Pp 118-124 (2015) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892015000200008&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 https://doaj.org/article/d0608d167d6e4f778b08cc29404ae3d5 |
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