Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil.
The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We inv...
Published in: | PLOS Neglected Tropical Diseases |
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Online Access: | https://doi.org/10.1371/journal.pntd.0006525 https://doaj.org/article/d00c6570e6de4d15a9cdae225e845438 |
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ftdoajarticles:oai:doaj.org/article:d00c6570e6de4d15a9cdae225e845438 2023-05-15T15:04:00+02:00 Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. Tauyne Menegaldo Pinheiro Mânlio Tasso de Oliveira Mota Aripuanã Sakurada Aranha Watanabe Joice Matos Biselli-Périco Betânia Paiva Drumond Milene Rocha Ribeiro Danila Vedovello João Pessoa Araújo Paulo Filemon Paolucci Pimenta Bárbara Aparecida Chaves Mayara Marques Carneiro da Silva Izabella Cristina Andrade Batista Michelle Premazzi Papa Lana Monteiro Meuren Carolina Gonçalves de Oliveira Lucas Flavio Lemos Matassoli Laura Helena Vega Gonzales Gil Adriana Bozzi Carlos Eduardo Calzavara-Silva Luciana Barros de Arruda Danielle da Glória de Souza Mauro Martins Teixeira Nikos Vasilakis Maurício Lacerda Nogueira 2018-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006525 https://doaj.org/article/d00c6570e6de4d15a9cdae225e845438 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5993327?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006525 https://doaj.org/article/d00c6570e6de4d15a9cdae225e845438 PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006525 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006525 2022-12-31T00:59:05Z The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in São José do Rio Preto. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 5 e0006525 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tauyne Menegaldo Pinheiro Mânlio Tasso de Oliveira Mota Aripuanã Sakurada Aranha Watanabe Joice Matos Biselli-Périco Betânia Paiva Drumond Milene Rocha Ribeiro Danila Vedovello João Pessoa Araújo Paulo Filemon Paolucci Pimenta Bárbara Aparecida Chaves Mayara Marques Carneiro da Silva Izabella Cristina Andrade Batista Michelle Premazzi Papa Lana Monteiro Meuren Carolina Gonçalves de Oliveira Lucas Flavio Lemos Matassoli Laura Helena Vega Gonzales Gil Adriana Bozzi Carlos Eduardo Calzavara-Silva Luciana Barros de Arruda Danielle da Glória de Souza Mauro Martins Teixeira Nikos Vasilakis Maurício Lacerda Nogueira Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in São José do Rio Preto. |
format |
Article in Journal/Newspaper |
author |
Tauyne Menegaldo Pinheiro Mânlio Tasso de Oliveira Mota Aripuanã Sakurada Aranha Watanabe Joice Matos Biselli-Périco Betânia Paiva Drumond Milene Rocha Ribeiro Danila Vedovello João Pessoa Araújo Paulo Filemon Paolucci Pimenta Bárbara Aparecida Chaves Mayara Marques Carneiro da Silva Izabella Cristina Andrade Batista Michelle Premazzi Papa Lana Monteiro Meuren Carolina Gonçalves de Oliveira Lucas Flavio Lemos Matassoli Laura Helena Vega Gonzales Gil Adriana Bozzi Carlos Eduardo Calzavara-Silva Luciana Barros de Arruda Danielle da Glória de Souza Mauro Martins Teixeira Nikos Vasilakis Maurício Lacerda Nogueira |
author_facet |
Tauyne Menegaldo Pinheiro Mânlio Tasso de Oliveira Mota Aripuanã Sakurada Aranha Watanabe Joice Matos Biselli-Périco Betânia Paiva Drumond Milene Rocha Ribeiro Danila Vedovello João Pessoa Araújo Paulo Filemon Paolucci Pimenta Bárbara Aparecida Chaves Mayara Marques Carneiro da Silva Izabella Cristina Andrade Batista Michelle Premazzi Papa Lana Monteiro Meuren Carolina Gonçalves de Oliveira Lucas Flavio Lemos Matassoli Laura Helena Vega Gonzales Gil Adriana Bozzi Carlos Eduardo Calzavara-Silva Luciana Barros de Arruda Danielle da Glória de Souza Mauro Martins Teixeira Nikos Vasilakis Maurício Lacerda Nogueira |
author_sort |
Tauyne Menegaldo Pinheiro |
title |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. |
title_short |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. |
title_full |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. |
title_fullStr |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. |
title_full_unstemmed |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. |
title_sort |
viral immunogenicity determines epidemiological fitness in a cohort of denv-1 infection in brazil. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006525 https://doaj.org/article/d00c6570e6de4d15a9cdae225e845438 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006525 (2018) |
op_relation |
http://europepmc.org/articles/PMC5993327?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006525 https://doaj.org/article/d00c6570e6de4d15a9cdae225e845438 |
op_doi |
https://doi.org/10.1371/journal.pntd.0006525 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
5 |
container_start_page |
e0006525 |
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1766335835369635840 |