Introgression between Anopheles gambiae and Anopheles coluzzii in Burkina Faso and its associations with kdr resistance and Plasmodium infection
Abstract Background Insecticide resistance in Anopheles coluzzii mosquitoes has become widespread throughout West Africa including in Burkina Faso. The insecticide resistance allele (kdr or L1014F) is a prime indicator that is highly correlated with phenotypic resistance in West Africa. Studies from...
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ftdoajarticles:oai:doaj.org/article:cff28f0b91604dbabcb56490b818d711 2023-05-15T15:11:46+02:00 Introgression between Anopheles gambiae and Anopheles coluzzii in Burkina Faso and its associations with kdr resistance and Plasmodium infection Mark J. Hanemaaijer Hannah Higgins Ipek Eralp Youki Yamasaki Norbert Becker Oscar D. Kirstein Gregory C. Lanzaro Yoosook Lee 2019-04-01T00:00:00Z https://doi.org/10.1186/s12936-019-2759-1 https://doaj.org/article/cff28f0b91604dbabcb56490b818d711 EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2759-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2759-1 1475-2875 https://doaj.org/article/cff28f0b91604dbabcb56490b818d711 Malaria Journal, Vol 18, Iss 1, Pp 1-6 (2019) Anopheles Insecticide resistance Gene flow Plasmodium Malaria vector Burkina Faso Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2759-1 2022-12-31T13:49:09Z Abstract Background Insecticide resistance in Anopheles coluzzii mosquitoes has become widespread throughout West Africa including in Burkina Faso. The insecticide resistance allele (kdr or L1014F) is a prime indicator that is highly correlated with phenotypic resistance in West Africa. Studies from Benin, Ghana and Mali have suggested that the source of the L1014F is introgression of the 2L divergence island via interspecific hybridization with Anopheles gambiae. The goal of this study was to characterize local mosquito populations in the Nouna Department, Burkina Faso with respect to: (i) the extent of introgression between An. coluzzii and An. gambiae, (ii) the frequency of the L1014F mutation and (iii) Plasmodium infection rates. Methods A total of 95 mosquitoes were collected from ten sites surrounding Nouna town in Kossi Province, Burkina Faso in 2012. The species composition, the extent of introgression in An. coluzzii mosquitoes and their Plasmodium infection rates were identified with a modified version of the “Divergence Island SNP” (DIS) genotyping assay. Results The mosquito collection contained 70.5% An. coluzzii, 89.3% of which carried a 3 Mb genomic region on the 2L chromosome with L1014F insecticide resistance mutation that was introgressed from An. gambiae. In addition, 22.4% in the introgressed An. coluzzii specimens were infected with Plasmodium falciparum, whereas none of the non-introgressed (“pure”) An. coluzzii were infected. Conclusion This paper is the first report providing divergence island SNP genotypes for natural population of Burkina Faso and corresponding Plasmodium infection rates. These observations warrant further study and could have a major impact on future malaria control strategies in Burkina Faso. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Anopheles Insecticide resistance Gene flow Plasmodium Malaria vector Burkina Faso Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Anopheles Insecticide resistance Gene flow Plasmodium Malaria vector Burkina Faso Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Mark J. Hanemaaijer Hannah Higgins Ipek Eralp Youki Yamasaki Norbert Becker Oscar D. Kirstein Gregory C. Lanzaro Yoosook Lee Introgression between Anopheles gambiae and Anopheles coluzzii in Burkina Faso and its associations with kdr resistance and Plasmodium infection |
topic_facet |
Anopheles Insecticide resistance Gene flow Plasmodium Malaria vector Burkina Faso Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Insecticide resistance in Anopheles coluzzii mosquitoes has become widespread throughout West Africa including in Burkina Faso. The insecticide resistance allele (kdr or L1014F) is a prime indicator that is highly correlated with phenotypic resistance in West Africa. Studies from Benin, Ghana and Mali have suggested that the source of the L1014F is introgression of the 2L divergence island via interspecific hybridization with Anopheles gambiae. The goal of this study was to characterize local mosquito populations in the Nouna Department, Burkina Faso with respect to: (i) the extent of introgression between An. coluzzii and An. gambiae, (ii) the frequency of the L1014F mutation and (iii) Plasmodium infection rates. Methods A total of 95 mosquitoes were collected from ten sites surrounding Nouna town in Kossi Province, Burkina Faso in 2012. The species composition, the extent of introgression in An. coluzzii mosquitoes and their Plasmodium infection rates were identified with a modified version of the “Divergence Island SNP” (DIS) genotyping assay. Results The mosquito collection contained 70.5% An. coluzzii, 89.3% of which carried a 3 Mb genomic region on the 2L chromosome with L1014F insecticide resistance mutation that was introgressed from An. gambiae. In addition, 22.4% in the introgressed An. coluzzii specimens were infected with Plasmodium falciparum, whereas none of the non-introgressed (“pure”) An. coluzzii were infected. Conclusion This paper is the first report providing divergence island SNP genotypes for natural population of Burkina Faso and corresponding Plasmodium infection rates. These observations warrant further study and could have a major impact on future malaria control strategies in Burkina Faso. |
format |
Article in Journal/Newspaper |
author |
Mark J. Hanemaaijer Hannah Higgins Ipek Eralp Youki Yamasaki Norbert Becker Oscar D. Kirstein Gregory C. Lanzaro Yoosook Lee |
author_facet |
Mark J. Hanemaaijer Hannah Higgins Ipek Eralp Youki Yamasaki Norbert Becker Oscar D. Kirstein Gregory C. Lanzaro Yoosook Lee |
author_sort |
Mark J. Hanemaaijer |
title |
Introgression between Anopheles gambiae and Anopheles coluzzii in Burkina Faso and its associations with kdr resistance and Plasmodium infection |
title_short |
Introgression between Anopheles gambiae and Anopheles coluzzii in Burkina Faso and its associations with kdr resistance and Plasmodium infection |
title_full |
Introgression between Anopheles gambiae and Anopheles coluzzii in Burkina Faso and its associations with kdr resistance and Plasmodium infection |
title_fullStr |
Introgression between Anopheles gambiae and Anopheles coluzzii in Burkina Faso and its associations with kdr resistance and Plasmodium infection |
title_full_unstemmed |
Introgression between Anopheles gambiae and Anopheles coluzzii in Burkina Faso and its associations with kdr resistance and Plasmodium infection |
title_sort |
introgression between anopheles gambiae and anopheles coluzzii in burkina faso and its associations with kdr resistance and plasmodium infection |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2759-1 https://doaj.org/article/cff28f0b91604dbabcb56490b818d711 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-6 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2759-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2759-1 1475-2875 https://doaj.org/article/cff28f0b91604dbabcb56490b818d711 |
op_doi |
https://doi.org/10.1186/s12936-019-2759-1 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
_version_ |
1766342568691367936 |