Sensibilidade de leveduras do gênero Candida, isoladas de pacientes com câncer, a antifúngicos poliênicos Candida from cancer patients: susceptibility "in vitro" to polyene antifungal agents

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Sydney Hartz Alves, Ariete Emily Cury
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1992
• Subjects: Candida; Sensibilidade; Antifungicos; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46651992000300012; https://doaj.org/article/cfc853c3e47042a6b5955886a8814ee2

Por meio da determinação da CIM (Concentração Inibitória Mínima) e da CFM (Concentração Fungicida Mínima), os autores compararam a sensibilidade de amostras de Candida isoladas de pacientes com câncer, com as de cepas isoladas de pacientes sem câncer, frente à anfotericina B e a nistatina. Os autores não verificaram diferenças significativas entre os dois grupos estudados e discutem o fenômeno da resistência de Candida a antifungicos poliênicos Candida strains susceptibility from cancer patients were compared with Candida strains susceptibility from patients, without cancer by MIC (Minimal Inhibitory Concentration) and MFC (Minimal Fungicidal Concentration) to Amphotericin B and Nystatin. Broth dilution method and Agar dilution method were the procedure employed. The authors find no significant differences between the studied groups. The problem of Candida resistance to polyene antifungals is discussed