Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis.
Brucellosis, caused by Brucella abortus, is a major disease of cattle and humans worldwide distributed. Eradication and control of the disease has been difficult in Central and South America, Central Asia, the Mediterranean and the Middle East. Epidemiological strategies combined with phylogenetic m...
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ftdoajarticles:oai:doaj.org/article:cfc62e8e8fd44e7e874905d07b3b1522 2023-05-15T15:16:38+02:00 Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis. Marcela Suárez-Esquivel Gabriela Hernández-Mora Nazareth Ruiz-Villalobos Elías Barquero-Calvo Carlos Chacón-Díaz Jason T Ladner Gerardo Oviedo-Sánchez Jeffrey T Foster Norman Rojas-Campos Esteban Chaves-Olarte Nicholas R Thomson Edgardo Moreno Caterina Guzmán-Verri 2020-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008235 https://doaj.org/article/cfc62e8e8fd44e7e874905d07b3b1522 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008235 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008235 https://doaj.org/article/cfc62e8e8fd44e7e874905d07b3b1522 PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008235 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008235 2022-12-30T22:39:22Z Brucellosis, caused by Brucella abortus, is a major disease of cattle and humans worldwide distributed. Eradication and control of the disease has been difficult in Central and South America, Central Asia, the Mediterranean and the Middle East. Epidemiological strategies combined with phylogenetic methods provide the high-resolution power needed to study relationships between surveillance data and pathogen population dynamics, using genetic diversity and spatiotemporal distributions. This information is crucial for prevention and control of disease spreading at a local and worldwide level. In Costa Rica (CR), the disease was first reported at the beginning of the 20th century and has not been controlled despite many efforts. We characterized 188 B. abortus isolates from CR recovered from cattle, humans and water buffalo, from 2003 to 2018, and whole genome sequencing (WGS) was performed in 95 of them. They were also assessed based on geographic origin, date of introduction, and phylogenetic associations in a worldwide and national context. Our results show circulation of five B. abortus lineages (I to V) in CR, phylogenetically related to isolates from the United States, United Kingdom, and South America. Lineage I was dominant and probably introduced at the end of the 19th century. Lineage II, represented by a single isolate from a water buffalo, clustered with a Colombian sample, and was likely introduced after 1845. Lineages III and IV were likely introduced during the early 2000s. Fourteen isolates from humans were found within the same lineage (lineage I) regardless of their geographic origin within the country. The main CR lineages, introduced more than 100 years ago, are widely spread throughout the country, in contrast to new introductions that seemed to be more geographically restricted. Following the brucellosis prevalence and the farming practices of several middle- and low-income countries, similar scenarios could be found in other regions worldwide. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 4 e0008235 |
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ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Marcela Suárez-Esquivel Gabriela Hernández-Mora Nazareth Ruiz-Villalobos Elías Barquero-Calvo Carlos Chacón-Díaz Jason T Ladner Gerardo Oviedo-Sánchez Jeffrey T Foster Norman Rojas-Campos Esteban Chaves-Olarte Nicholas R Thomson Edgardo Moreno Caterina Guzmán-Verri Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Brucellosis, caused by Brucella abortus, is a major disease of cattle and humans worldwide distributed. Eradication and control of the disease has been difficult in Central and South America, Central Asia, the Mediterranean and the Middle East. Epidemiological strategies combined with phylogenetic methods provide the high-resolution power needed to study relationships between surveillance data and pathogen population dynamics, using genetic diversity and spatiotemporal distributions. This information is crucial for prevention and control of disease spreading at a local and worldwide level. In Costa Rica (CR), the disease was first reported at the beginning of the 20th century and has not been controlled despite many efforts. We characterized 188 B. abortus isolates from CR recovered from cattle, humans and water buffalo, from 2003 to 2018, and whole genome sequencing (WGS) was performed in 95 of them. They were also assessed based on geographic origin, date of introduction, and phylogenetic associations in a worldwide and national context. Our results show circulation of five B. abortus lineages (I to V) in CR, phylogenetically related to isolates from the United States, United Kingdom, and South America. Lineage I was dominant and probably introduced at the end of the 19th century. Lineage II, represented by a single isolate from a water buffalo, clustered with a Colombian sample, and was likely introduced after 1845. Lineages III and IV were likely introduced during the early 2000s. Fourteen isolates from humans were found within the same lineage (lineage I) regardless of their geographic origin within the country. The main CR lineages, introduced more than 100 years ago, are widely spread throughout the country, in contrast to new introductions that seemed to be more geographically restricted. Following the brucellosis prevalence and the farming practices of several middle- and low-income countries, similar scenarios could be found in other regions worldwide. |
format |
Article in Journal/Newspaper |
author |
Marcela Suárez-Esquivel Gabriela Hernández-Mora Nazareth Ruiz-Villalobos Elías Barquero-Calvo Carlos Chacón-Díaz Jason T Ladner Gerardo Oviedo-Sánchez Jeffrey T Foster Norman Rojas-Campos Esteban Chaves-Olarte Nicholas R Thomson Edgardo Moreno Caterina Guzmán-Verri |
author_facet |
Marcela Suárez-Esquivel Gabriela Hernández-Mora Nazareth Ruiz-Villalobos Elías Barquero-Calvo Carlos Chacón-Díaz Jason T Ladner Gerardo Oviedo-Sánchez Jeffrey T Foster Norman Rojas-Campos Esteban Chaves-Olarte Nicholas R Thomson Edgardo Moreno Caterina Guzmán-Verri |
author_sort |
Marcela Suárez-Esquivel |
title |
Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis. |
title_short |
Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis. |
title_full |
Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis. |
title_fullStr |
Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis. |
title_full_unstemmed |
Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis. |
title_sort |
persistence of brucella abortus lineages revealed by genomic characterization and phylodynamic analysis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008235 https://doaj.org/article/cfc62e8e8fd44e7e874905d07b3b1522 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008235 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008235 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008235 https://doaj.org/article/cfc62e8e8fd44e7e874905d07b3b1522 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008235 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
4 |
container_start_page |
e0008235 |
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1766346930448760832 |