Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors
The standard reference for pathogenic and nonpathogenic amoebae is the human parasite Entamoeba histolytica; a direct correlation between virulence and protease expression has been demonstrated for this amoeba. Traditionally, proteases are considered virulence factors, including those that produce c...
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ftdoajarticles:oai:doaj.org/article:cf0113ebe80f45f3a7aa5abcf435c520 2024-09-09T19:25:33+00:00 Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors Jesús Serrano-Luna Carolina Piña-Vázquez Magda Reyes-López Guillermo Ortiz-Estrada Mireya de la Garza 2013-01-01T00:00:00Z https://doi.org/10.1155/2013/890603 https://doaj.org/article/cf0113ebe80f45f3a7aa5abcf435c520 EN eng Wiley http://dx.doi.org/10.1155/2013/890603 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2013/890603 https://doaj.org/article/cf0113ebe80f45f3a7aa5abcf435c520 Journal of Tropical Medicine, Vol 2013 (2013) Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles https://doi.org/10.1155/2013/890603 2024-08-05T17:48:46Z The standard reference for pathogenic and nonpathogenic amoebae is the human parasite Entamoeba histolytica; a direct correlation between virulence and protease expression has been demonstrated for this amoeba. Traditionally, proteases are considered virulence factors, including those that produce cytopathic effects in the host or that have been implicated in manipulating the immune response. Here, we expand the scope to other amoebae, including less-pathogenic Entamoeba species and highly pathogenic free-living amoebae. In this paper, proteases that affect mucin, extracellular matrix, immune system components, and diverse tissues and cells are included, based on studies in amoebic cultures and animal models. We also include proteases used by amoebae to degrade iron-containing proteins because iron scavenger capacity is currently considered a virulence factor for pathogens. In addition, proteases that have a role in adhesion and encystation, which are essential for establishing and transmitting infection, are discussed. The study of proteases and their specific inhibitors is relevant to the search for new therapeutic targets and to increase the power of drugs used to treat the diseases caused by these complex microorganisms. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2013 1 32 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Jesús Serrano-Luna Carolina Piña-Vázquez Magda Reyes-López Guillermo Ortiz-Estrada Mireya de la Garza Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
The standard reference for pathogenic and nonpathogenic amoebae is the human parasite Entamoeba histolytica; a direct correlation between virulence and protease expression has been demonstrated for this amoeba. Traditionally, proteases are considered virulence factors, including those that produce cytopathic effects in the host or that have been implicated in manipulating the immune response. Here, we expand the scope to other amoebae, including less-pathogenic Entamoeba species and highly pathogenic free-living amoebae. In this paper, proteases that affect mucin, extracellular matrix, immune system components, and diverse tissues and cells are included, based on studies in amoebic cultures and animal models. We also include proteases used by amoebae to degrade iron-containing proteins because iron scavenger capacity is currently considered a virulence factor for pathogens. In addition, proteases that have a role in adhesion and encystation, which are essential for establishing and transmitting infection, are discussed. The study of proteases and their specific inhibitors is relevant to the search for new therapeutic targets and to increase the power of drugs used to treat the diseases caused by these complex microorganisms. |
format |
Article in Journal/Newspaper |
author |
Jesús Serrano-Luna Carolina Piña-Vázquez Magda Reyes-López Guillermo Ortiz-Estrada Mireya de la Garza |
author_facet |
Jesús Serrano-Luna Carolina Piña-Vázquez Magda Reyes-López Guillermo Ortiz-Estrada Mireya de la Garza |
author_sort |
Jesús Serrano-Luna |
title |
Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors |
title_short |
Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors |
title_full |
Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors |
title_fullStr |
Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors |
title_full_unstemmed |
Proteases from Entamoeba spp. and Pathogenic Free-Living Amoebae as Virulence Factors |
title_sort |
proteases from entamoeba spp. and pathogenic free-living amoebae as virulence factors |
publisher |
Wiley |
publishDate |
2013 |
url |
https://doi.org/10.1155/2013/890603 https://doaj.org/article/cf0113ebe80f45f3a7aa5abcf435c520 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2013 (2013) |
op_relation |
http://dx.doi.org/10.1155/2013/890603 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2013/890603 https://doaj.org/article/cf0113ebe80f45f3a7aa5abcf435c520 |
op_doi |
https://doi.org/10.1155/2013/890603 |
container_title |
Journal of Tropical Medicine |
container_volume |
2013 |
container_start_page |
1 |
op_container_end_page |
32 |
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1809895324452388864 |