Geographical distribution and relative risk of Anjozorobe virus (Thailand orthohantavirus) infection in black rats (Rattus rattus) in Madagascar
Abstract Background Hantavirus infection is a zoonotic disease that is associated with hemorrhagic fever with renal syndrome and cardiopulmonary syndrome in human. Anjozorobe virus, a representative virus of Thailand orthohantavirus (THAIV), was recently discovered from rodents in Anjozorobe-Angavo...
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ftdoajarticles:oai:doaj.org/article:cecd2a1c826445dc96ce77fc0daf75fc 2023-05-15T18:04:50+02:00 Geographical distribution and relative risk of Anjozorobe virus (Thailand orthohantavirus) infection in black rats (Rattus rattus) in Madagascar Vololoniaina Raharinosy Marie-Marie Olive Fehivola Mandanirina Andriamiarimanana Soa Fy Andriamandimby Jean-Pierre Ravalohery Seta Andriamamonjy Claudia Filippone Danielle Aurore Doll Rakoto Sandra Telfer Jean-Michel Heraud 2018-05-01T00:00:00Z https://doi.org/10.1186/s12985-018-0992-9 https://doaj.org/article/cecd2a1c826445dc96ce77fc0daf75fc EN eng BMC http://link.springer.com/article/10.1186/s12985-018-0992-9 https://doaj.org/toc/1743-422X doi:10.1186/s12985-018-0992-9 1743-422X https://doaj.org/article/cecd2a1c826445dc96ce77fc0daf75fc Virology Journal, Vol 15, Iss 1, Pp 1-11 (2018) Hantavirus Anjozorobe virus Thailand orthohantavirus Rodent small terrestrial mammals Risk factors Madagascar Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12985-018-0992-9 2022-12-31T01:54:20Z Abstract Background Hantavirus infection is a zoonotic disease that is associated with hemorrhagic fever with renal syndrome and cardiopulmonary syndrome in human. Anjozorobe virus, a representative virus of Thailand orthohantavirus (THAIV), was recently discovered from rodents in Anjozorobe-Angavo forest in Madagascar. To assess the circulation of hantavirus at the national level, we carried out a survey of small terrestrial mammals from representative regions of the island and identified environmental factors associated with hantavirus infection. As we were ultimately interested in the potential for human exposure, we focused our research in the peridomestic area. Methods Sampling was achieved in twenty districts of Madagascar, with a rural and urban zone in each district. Animals were trapped from a range of habitats and examined for hantavirus RNA by nested RT-PCR. We also investigated the relationship between hantavirus infection probability in rats and possible risk factors by using Generalized Linear Mixed Models. Results Overall, 1242 specimens from seven species were collected (Rattus rattus, Rattus norvegicus, Mus musculus, Suncus murinus, Setifer setosus, Tenrec ecaudatus, Hemicentetes semispinosus). Overall, 12.4% (111/897) of Rattus rattus and 1.6% (2/125) of Mus musculus were tested positive for THAIV. Rats captured within houses were less likely to be infected than rats captured in other habitats, whilst rats from sites characterized by high precipitation and relatively low seasonality were more likely to be infected than those from other areas. Older animals were more likely to be infected, with infection probability showing a strong increase with weight. Conclusions We report widespread distribution of THAIV in the peridomestic rats of Madagascar, with highest prevalence for those living in humid areas. Although the potential risk of infection to human may also be widespread, our results provide a first indication of specific zone with high transmission. Gathered data will be helpful to ... Article in Journal/Newspaper Rattus rattus Directory of Open Access Journals: DOAJ Articles Virology Journal 15 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Hantavirus Anjozorobe virus Thailand orthohantavirus Rodent small terrestrial mammals Risk factors Madagascar Infectious and parasitic diseases RC109-216 |
spellingShingle |
Hantavirus Anjozorobe virus Thailand orthohantavirus Rodent small terrestrial mammals Risk factors Madagascar Infectious and parasitic diseases RC109-216 Vololoniaina Raharinosy Marie-Marie Olive Fehivola Mandanirina Andriamiarimanana Soa Fy Andriamandimby Jean-Pierre Ravalohery Seta Andriamamonjy Claudia Filippone Danielle Aurore Doll Rakoto Sandra Telfer Jean-Michel Heraud Geographical distribution and relative risk of Anjozorobe virus (Thailand orthohantavirus) infection in black rats (Rattus rattus) in Madagascar |
topic_facet |
Hantavirus Anjozorobe virus Thailand orthohantavirus Rodent small terrestrial mammals Risk factors Madagascar Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Hantavirus infection is a zoonotic disease that is associated with hemorrhagic fever with renal syndrome and cardiopulmonary syndrome in human. Anjozorobe virus, a representative virus of Thailand orthohantavirus (THAIV), was recently discovered from rodents in Anjozorobe-Angavo forest in Madagascar. To assess the circulation of hantavirus at the national level, we carried out a survey of small terrestrial mammals from representative regions of the island and identified environmental factors associated with hantavirus infection. As we were ultimately interested in the potential for human exposure, we focused our research in the peridomestic area. Methods Sampling was achieved in twenty districts of Madagascar, with a rural and urban zone in each district. Animals were trapped from a range of habitats and examined for hantavirus RNA by nested RT-PCR. We also investigated the relationship between hantavirus infection probability in rats and possible risk factors by using Generalized Linear Mixed Models. Results Overall, 1242 specimens from seven species were collected (Rattus rattus, Rattus norvegicus, Mus musculus, Suncus murinus, Setifer setosus, Tenrec ecaudatus, Hemicentetes semispinosus). Overall, 12.4% (111/897) of Rattus rattus and 1.6% (2/125) of Mus musculus were tested positive for THAIV. Rats captured within houses were less likely to be infected than rats captured in other habitats, whilst rats from sites characterized by high precipitation and relatively low seasonality were more likely to be infected than those from other areas. Older animals were more likely to be infected, with infection probability showing a strong increase with weight. Conclusions We report widespread distribution of THAIV in the peridomestic rats of Madagascar, with highest prevalence for those living in humid areas. Although the potential risk of infection to human may also be widespread, our results provide a first indication of specific zone with high transmission. Gathered data will be helpful to ... |
format |
Article in Journal/Newspaper |
author |
Vololoniaina Raharinosy Marie-Marie Olive Fehivola Mandanirina Andriamiarimanana Soa Fy Andriamandimby Jean-Pierre Ravalohery Seta Andriamamonjy Claudia Filippone Danielle Aurore Doll Rakoto Sandra Telfer Jean-Michel Heraud |
author_facet |
Vololoniaina Raharinosy Marie-Marie Olive Fehivola Mandanirina Andriamiarimanana Soa Fy Andriamandimby Jean-Pierre Ravalohery Seta Andriamamonjy Claudia Filippone Danielle Aurore Doll Rakoto Sandra Telfer Jean-Michel Heraud |
author_sort |
Vololoniaina Raharinosy |
title |
Geographical distribution and relative risk of Anjozorobe virus (Thailand orthohantavirus) infection in black rats (Rattus rattus) in Madagascar |
title_short |
Geographical distribution and relative risk of Anjozorobe virus (Thailand orthohantavirus) infection in black rats (Rattus rattus) in Madagascar |
title_full |
Geographical distribution and relative risk of Anjozorobe virus (Thailand orthohantavirus) infection in black rats (Rattus rattus) in Madagascar |
title_fullStr |
Geographical distribution and relative risk of Anjozorobe virus (Thailand orthohantavirus) infection in black rats (Rattus rattus) in Madagascar |
title_full_unstemmed |
Geographical distribution and relative risk of Anjozorobe virus (Thailand orthohantavirus) infection in black rats (Rattus rattus) in Madagascar |
title_sort |
geographical distribution and relative risk of anjozorobe virus (thailand orthohantavirus) infection in black rats (rattus rattus) in madagascar |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12985-018-0992-9 https://doaj.org/article/cecd2a1c826445dc96ce77fc0daf75fc |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Virology Journal, Vol 15, Iss 1, Pp 1-11 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12985-018-0992-9 https://doaj.org/toc/1743-422X doi:10.1186/s12985-018-0992-9 1743-422X https://doaj.org/article/cecd2a1c826445dc96ce77fc0daf75fc |
op_doi |
https://doi.org/10.1186/s12985-018-0992-9 |
container_title |
Virology Journal |
container_volume |
15 |
container_issue |
1 |
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1766176247265624064 |